Figure 10From: Stable alterations of CD44 isoform expression in prostate cancer cells decrease invasion and growth and alter ligand binding and chemosensitivity Antisense inhibition of PAK2 causes a decrease in p-merlin in PC-3M cells. PAK2 is an enzyme that phosphorylates (and activates) merlin; thus, the preferentially expressed hypophosphorylated form of merlin in PC-3M cells depends on PAK2, as it does in DU145 cells[12].Back to article page