Table 7 Study Measurements and Sub-Studies

Physical measurements and tests

   Height, weight, and body mass index

   Body composition

   Resting and exercise heart rate

   Resting and exercise blood pressure

   Resting and exercise 12-lead ECG

   Peak and submaximal oxygen consumption

   Ventilatory threshold

Mechanistic physiological measurements

   Resting and exercise echocardiogram

   Skeletal muscle function (fiber type distribution, oxidative capacity, and muscular strength)

   Pulmonary function

   Hemoglobin concentration

   Resting and exercise oxygen saturation

   Each intervention (exercise or attention control) session: heart rate, blood pressure, oxygen saturation, RPE

Patient-reported outcomes (questionnaire-based)

   Medications

   Quality of life

   Fatigue

   Dyspnea

   Depression

   Adverse events (Common Terminology Criteria for Adverse Events; CTCAE v.4.0)

Substudies

   Genetic studies to examine differences to exercise stimulus

   Predictors of exercise adherence

   Pilot studies for exercise-induced changes in peripheral gene expression