Table 1 Subject Eligibility Criteria

Inclusion Criteria

   At least 21 years old.

   An interval of at least 6 months following surgical resection.

VO_2peak has been shown to (spontaneously) recover, to a limited degree, immediately following (~3 months) and stabilize at ~6 months post pulmonary resection. Thus, to accurately determine the effects of exercise training on VO_2peak in this setting, we felt it was critically important to initiate study procedures (i.e., recruit and randomize patients) once changes in VO_2peak have stabilized to minimize the effects of natural postsurgical recovery on improvements in VO_2peak,

   An interval of no longer than 36 months post-resection

   Karnofsky performance status of at least 70% at study entry

   Estimated life expectancy of ≥6 months

   Ability to read and understand English

   Primary attending oncologist approval

   Sedentary

Patients not performing regular exercise. Regular exercise is defined as ≥5 days a week, ≥30 minutes each session, at a moderate or vigorous intensity for the past month).

   Willingness to be randomized

   Signed informed consent prior to initiation of study-related procedures

   Reside within driving distance of DUMC, as necessitated by the clinic-based assessments and supervised exercise training interventions

Exclusion Criteria

   Presence of a concurrent, actively treated other malignancy or history of other malignancy treated within the past 3 years (other than non-melanoma skin cancer)

   Presence of metastatic disease

   Scheduled to receive any form of adjuvant cancer therapy

   Contraindications to maximal exercise testing as recommended by the American Thoracic Society and exercise testing guidelines for cancer patients