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Figure 1 | BMC Cancer

Figure 1

From: Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: Comparison of the CGH profiles between cancer cell lines and primary cancer tissues

Figure 1

The frequency of DCNAs detected by array-based CGH in the breast cancer cell lines (n = 24) (a) and the primary breast cancer tissues (n = 35) (b). Note the apparent similarity of the DCNA frequency pattern between two groups, gains of 1q, 8q, 17q and chromosome 20 and losses of 8p, 11q, 16q and 17p are frequent in both groups. However, the frequency of DCNA at each chromosomal region is different between these two groups, and other recurrent DCNAs are detected in the cell lines. Gains of 5p and 20q and losses of 4p, 18q and Xq are highly frequent in the cell lines in comparison to the tumor tissues. Green lines denote the frequency of DNA copy number gain in each BAC clone and red lines denote the frequency of DNA copy number loss in each BAC clone. Ordinate; frequency of DCNA for each BAC clone on the array, abscissa; chromosome number.

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BMC Cancer

ISSN: 1471-2407

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