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Table 2 Association of endothelial and cytoplasmic CA II, CA IX and CA XII immunostaining with clinicopathologic variables in medulloblastomas (MB) and primitive neuroectodermal tumours (PNET).

From: The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis

  endothelial CA II positivity N cytoplasmic CA II positivity N CA IX positivity N CA XII positivity N
Primary tumors All MB PNET All MB PNET All MB PNET All MB PNET
  33 27 6 33 27 6 35 28 7 34 27 7
Age             
< 3 years 5 2 3 5 3 2 1 1 0 4* 3+ 1
> 3 years 12 10 2 18 15 3 7 6 1 0 0 0
Gender             
-female 6 3 3 10 7 3 1** 0++ 1 1 0 1
-male 11 9 2 13 11 2 7 7 0 3 3 0
Localization             
-cerebellum 12    18    7    3   
-cerebrum 5    5    1    1   
Total material             
MIB-1 36 28 8 36 28 8 37 29 8 36 28 8
-below median 9 6 3 13 10 3 5 4 1 1 1 0
-above median 9 6 3 13 9 4 4 4 0 2 1 1
Apoptosis 37 29 8 37 29 8 39 30 9 38 29 9
-below median 8 5 3 15 11 4 5 5 0 1 1 0
-above median 10 7 3 12 9 3 4 3 1 3 2 1
Bcl-2 37 29 8 37 29 8 39 30 9 38 29 9
-negative 6 4 2 13 9 4 3 2 1 1 0 1
-positive 12 8 4 14 11 3 6 6 0 3 3 0
P53 37 29 8 37 29 8 39 30 9 38 29 9
-negative 15 6 1 23 9 1 7 4 0 3 0 0
-positive 3 6 5 4 11 6 2 4 1 1 3 1
ErbB2 37 29 8 37 29 8 39 30 9 38 29 9
-negative 8 10 5 11 10 5 6 7 0 2 1
-positive 10 2 1 16 2 2 3 1 1 4 1 0
  1. The total number of tumours analysed in each category is in bold.
  2. * p < 0.001, chi-square test
  3. ** p = 0.048, chi-square test
  4. + p < 0.001, chi-square test
  5. ++ p = 0.023, chi-square test
  6. Ψ p = 0.047, chi-square test