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Table 2 Genotype and allele frequencies of TP53 and MDM2 among cases and controls and their association with the risk of NPC.

From: Genetic polymorphisms of MDM2 and TP53 genes are associated with risk of nasopharyngeal carcinoma in a Chinese population

Genotype Cases (n = 522) Controls (n = 712) OR* (95% CI)
  no. (%) no. (%)  
TP53 72Arg>Pro    
Arg/Arg 117 (22.4) 226 (31.7) 1.00 (reference)
Arg/Pro 270 (51.7) 366 (51.4) 1.43 (1.22-2.13)
Pro/Pro 135 (25.9) 120 (16.9) 2.22 (1.58-3.10)
Pro allele frequency 0.518 0.426  
MDM2 309T>G    
TT 111 (21.2) 238 (33.4) 1.00 (reference)
TG 243 (46.6) 346 (48.6) 1.49 (1.16-2.06)
GG 168 (32.2) 128 (18.0) 2.83 (2.08-3.96)
G allele frequency 0.555 0.423  
  1. *OR and 95%CI were calculated by unconditional logistic regression, with TP53 Arg/Arg or MDM2 TT genotype as the reference group and adjusted by sex and age.