Table 2 Genotype and allele frequencies of TP53 and MDM2 among cases and controls and their association with the risk of NPC.
Genotype | Cases (n = 522) | Controls (n = 712) | OR* (95% CI) |
|---|---|---|---|
| Â | no. (%) | no. (%) | Â |
TP53 72Arg>Pro | Â | Â | Â |
Arg/Arg | 117 (22.4) | 226 (31.7) | 1.00 (reference) |
Arg/Pro | 270 (51.7) | 366 (51.4) | 1.43 (1.22-2.13) |
Pro/Pro | 135 (25.9) | 120 (16.9) | 2.22 (1.58-3.10) |
Pro allele frequency | 0.518 | 0.426 | Â |
MDM2 309T>G | Â | Â | Â |
TT | 111 (21.2) | 238 (33.4) | 1.00 (reference) |
TG | 243 (46.6) | 346 (48.6) | 1.49 (1.16-2.06) |
GG | 168 (32.2) | 128 (18.0) | 2.83 (2.08-3.96) |
G allele frequency | 0.555 | 0.423 | Â |