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Table 3 Univariate survival analysis according to histopathological variables and proliferation markers

From: Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma

Variables

n

Estimated survival rates (%)

p-valuea

  

5 years

10 years

 

Tumor thickness

   

0.001

   ≤2.0 mm

48

80

77

 

   2.1-4.0 mm

73

76

59

 

   >4.0 mm

81

49

43

 

Tumor ulceration

   

0.001

   absent

114

77

68

 

   present

83

54

44

 

Clark's level

   

<0.001

   II - IV

166

72

62

 

   V

35

40

32

 

Vascular infiltration

   

<0.001

   absent

162

73

61

 

   present

40

39

39

 

Tumor necrosis

   

<0.001

   absent

142

76

64

 

   present

57

39

36

 

Mitotic count (no./mm2)

   

0.008

   <1.7b

35

84

84

 

   ≥1.7

164

62

51

 

Ki-67 (% pos)

   

<0.0001

   ≤16b

49

89

86

 

   >16

138

57

47

 

PHH3 (% pos)

   

ns

   ≤0.8c

56

67

47

 

   >0.8

55

57

50

 

MCM4 (% pos)

   

ns

   ≤40.7c

48

61

43

 

   >40.7

48

58

46

 

Mitosin (SId)

   

ns

   lowb

45

58

47

 

   high

58

59

42

 
  1. aLog-rank test
  2. bCut-off point lower quartile
  3. cCut-off point median
  4. dAbbreviation: SI, staining index