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Table 3 Univariate survival analysis according to histopathological variables and proliferation markers

From: Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma

Variables n Estimated survival rates (%) p-valuea
   5 years 10 years  
Tumor thickness     0.001
   ≤2.0 mm 48 80 77  
   2.1-4.0 mm 73 76 59  
   >4.0 mm 81 49 43  
Tumor ulceration     0.001
   absent 114 77 68  
   present 83 54 44  
Clark's level     <0.001
   II - IV 166 72 62  
   V 35 40 32  
Vascular infiltration     <0.001
   absent 162 73 61  
   present 40 39 39  
Tumor necrosis     <0.001
   absent 142 76 64  
   present 57 39 36  
Mitotic count (no./mm2)     0.008
   <1.7b 35 84 84  
   ≥1.7 164 62 51  
Ki-67 (% pos)     <0.0001
   ≤16b 49 89 86  
   >16 138 57 47  
PHH3 (% pos)     ns
   ≤0.8c 56 67 47  
   >0.8 55 57 50  
MCM4 (% pos)     ns
   ≤40.7c 48 61 43  
   >40.7 48 58 46  
Mitosin (SId)     ns
   lowb 45 58 47  
   high 58 59 42  
  1. aLog-rank test
  2. bCut-off point lower quartile
  3. cCut-off point median
  4. dAbbreviation: SI, staining index