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Table 1 Associations between different proliferation markers and histopathological variables

From: Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma

  Mitotic count   Ki-67   PHH3   MCM4   Mitosin  
  (no./mm2)   (% pos)   (% pos)   (% pos)   (nc)  
  median p-valuea median p-valuea median p-valuea median p-valuea low high p-valueb
Tumor thickness   <0.001   <0.001   0.031   ns    ns
   ≤2.0 mm 1.7   19.0   0.4   43.0   4 7  
   2.1-4.0 mm 4.3   26.5   0.8   33.2   17 23  
   >4.0 mm 9.4   35.0   1.0   44.4   24 28  
Tumor ulceration   <0.001   <0.001   0.041   0.003    ns
   absent 4.3   23.5   0.6   32.0   18 26  
   present 9.4   33.0   1.4   46.4   27 30  
Tumor necrosis   <0.001   0.007   0.027   ns    ns
   absent 4.3   25.0   0.6   37.4   26 38  
   present 12.0   35.0   1.6   45.2   19 20  
Clark's level   0.038   0.015   ns   ns    ns
   II - IV 5.1   26.0   0.8   37.5   35 45  
   V 7.7   35.0   1.0   47.2   10 13  
Vascular invasion   0.052   0.027   ns   ns    ns
   absent 5.1   26.0   0.8   40.6   35 42  
   present 8.15   34.5   1.0   41.4   10 16  
  1. aMann-Whitney or Kruskal-Wallis test
  2. bChi-square test
  3. cStaining index, cut-off point lower quartile