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Table 1 Associations between different proliferation markers and histopathological variables

From: Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma

 

Mitotic count

 

Ki-67

 

PHH3

 

MCM4

 

Mitosin

 
 

(no./mm2)

 

(% pos)

 

(% pos)

 

(% pos)

 

(nc)

 
 

median

p-valuea

median

p-valuea

median

p-valuea

median

p-valuea

low

high

p-valueb

Tumor thickness

 

<0.001

 

<0.001

 

0.031

 

ns

  

ns

   ≤2.0 mm

1.7

 

19.0

 

0.4

 

43.0

 

4

7

 

   2.1-4.0 mm

4.3

 

26.5

 

0.8

 

33.2

 

17

23

 

   >4.0 mm

9.4

 

35.0

 

1.0

 

44.4

 

24

28

 

Tumor ulceration

 

<0.001

 

<0.001

 

0.041

 

0.003

  

ns

   absent

4.3

 

23.5

 

0.6

 

32.0

 

18

26

 

   present

9.4

 

33.0

 

1.4

 

46.4

 

27

30

 

Tumor necrosis

 

<0.001

 

0.007

 

0.027

 

ns

  

ns

   absent

4.3

 

25.0

 

0.6

 

37.4

 

26

38

 

   present

12.0

 

35.0

 

1.6

 

45.2

 

19

20

 

Clark's level

 

0.038

 

0.015

 

ns

 

ns

  

ns

   II - IV

5.1

 

26.0

 

0.8

 

37.5

 

35

45

 

   V

7.7

 

35.0

 

1.0

 

47.2

 

10

13

 

Vascular invasion

 

0.052

 

0.027

 

ns

 

ns

  

ns

   absent

5.1

 

26.0

 

0.8

 

40.6

 

35

42

 

   present

8.15

 

34.5

 

1.0

 

41.4

 

10

16

 
  1. aMann-Whitney or Kruskal-Wallis test
  2. bChi-square test
  3. cStaining index, cut-off point lower quartile