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Table 2 Bonferroni adjusted t-tests for comparisons between RAS gene expression in tumors, tumor-induced liver, and sham livers either with or without captopril treatment.

From: Changes in the renin angiotensin system during the development of colorectal cancer liver metastases

Gene

Comparison

Day 5

Day 10

Day 16

Day 21

ACE

Tumor control cf. sham

  

0.0003

0.3693

 

Tumor control cf. tumor captopril

  

0.0033

0.0001

 

Tumor control cf. liver control

  

0.0007

0.3508

 

Liver control cf. sham

0.0412

0.5001

0.4026

0.9496

 

Liver control cf. liver captopril

0.0005

0.2495

0.2839

0.6212

 

Liver captopril cf. sham

0.1202

0.5906

0.9216

0.6110

 

Tumor captopril cf. sham

  

0.1482

0.0001

 

Tumor captopril cf liver captopril

  

0.0796

0.0001

ACE2

Tumor control cf. sham

  

0.2276

0.0531

 

Tumor control cf. tumor captopril

  

0.2609

0.8660

 

Tumor control cf. liver control

  

0.9828

0.0011

 

Liver control cf. sham

0.9305

0.4077

0.6531

0.2105

 

Liver control cf. liver captopril

0.3797

0.2270

0.0598

0.3130

 

Liver captopril cf. sham

0.4554

0.6545

0.2146

0.8171

 

Tumor captopril cf. sham

  

0.0294

0.0838

 

Tumor captopril cf liver captopril

  

0.2259

0.0514

Ang

Tumor control cf. sham

  

0.0119

0.3345

 

Tumor control cf. tumor captopril

  

0.7069

0.8632

 

Tumor control cf. liver control

  

0.0134

0.0024

 

Liver control cf. sham

0.0923

0.6725

0.6830

0.0530

 

Liver control cf. liver captopril

0.0004

0.0120

0.0108

0.0090

 

Liver captopril cf. sham

0.0160

0.0052

0.0098

0.5520

 

Tumor captopril cf. sham

  

0.0043

0.2801

 

Tumor captopril cf liver captopril

  

0.7858

0.5997

AT1R

Tumor control cf. sham

  

0.1071

0.0223

 

Tumor control cf. tumor captopril

  

0.4844

0.6327

 

Tumor control cf. liver control

  

0.0019

0.0003

 

Liver control cf. sham

0.0030

0.8065

0.1292

0.6180

 

Liver control cf. liver captopril

0.0001

0.1617

0.0003

0.2222

 

Liver captopril cf. sham

0.0787

0.2352

0.0360

0.5013

 

Tumor captopril cf. sham

  

0.0261

0.0677

 

Tumor captopril cf liver captopril

  

0.8570

0.2443

AT2R

Tumor control cf. sham

  

0.7637

0.2765

 

Tumor control cf. tumor captopril

  

0.4973

0.9972

 

Tumor control cf. liver control

  

0.6145

0.0870

 

Liver control cf. sham

0.4505

0.2186

0.4791

0.8018

 

Liver control cf. liver captopril

0.4651

0.6104

0.0434

0.1241

 

Liver captopril cf. sham

0.9716

0.4497

0.2960

0.2765

 

Tumor captopril cf. sham

  

0.8127

0.0086

 

Tumor captopril cf liver captopril

  

0.2897

0.0749

MasR

Tumor control cf. sham

  

0.0090

0.0033

 

Tumor control cf. tumor captopril

  

0.0299

0.3405

 

Tumor control cf. liver control

  

0.0036

0.0046

 

Liver control cf. sham

0.4294

0.2097

0.9185

0.6467

 

Liver control cf. liver captopril

0.2900

0.1486

0.8491

0.3546

 

Liver captopril cf. sham

0.0902

0.7769

0.9501

0.2062

 

Tumor captopril cf. sham

  

0.3995

0.0339

 

Tumor captopril cf liver captopril

  

0.2990

0.3248

  1. Tumor comparisons have only been made for days 16 and 21 due to the difficult in obtaining sufficient samples at earlier stages (days 5 and 10). Comparisons between liver tissues, however, have been made at all stages (Days 5, 10, 16 and 21 post-tumor induction). Values were considered significant for P < 0.05 (highlighted in bold).
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BMC Cancer

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