Figure 4
From: Changes in the renin angiotensin system during the development of colorectal cancer liver metastases
ACE-positive cell counts in captopril treated and untreated tumors at days 16 and 21 after tumor-induction. Because all vascular endothelial cells stained in the liver regardless of treatment with captopril, cell counts for the corresponding normal liver were not performed. Changes in the number of ACE positive cells in response to captopril treatment was similar to ACE mRNA (see Figure 2), with greater numbers and mRNA expression in untreated CRC metastases at day 16, but an increase in mRNA expression and number of ACE-positive cells by day 21 in treated CRC metastases.