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Table 2 Summary of gene changes controlled by Rac1 and by Cdc42

From: Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts

Genes up-regulated

  

Name

Fold Change

Reference

Ubiquitin Conjugating enzyme 12 (UBC12) *

6.4

[39]

Elongation factor-1 alpha-2 *

2.3

[40]

Guanine nucleotide-binding regulatory protein (G-y-alpha)

2.2

 

mSin3A associated polypeptide p30 *

2.1

[41]

Rac protein kinase alpha

1.8

 

Coupling protein G(s) alpha-subunit (alpha-S1)

1.8

 

Histone H1x

1.8

 

80K-L protein *

1.6

[42]

Killer cell lectin-like receptor, Subfam. C, member 2 (NKG2C) *

1.6

[43]

Alpha subunit of GsGTP binding protein

1.5

 

Lipoprotein-associated coagulation inhibitor (LACI)

1.5

 

ATP synthase alpha subunit

1.3

 

Heat shock protein 70 (hsp70) *

1.3

[44]

Genes down-regulated

  

Name

Fold Change

 

Insulin-like growth factor-binding protein-3 *

-1.9

[45]

28s Ribosomal RNA gene

-1.6

 

Cyclooxygenase-2 (hCox-2) *

-1.6

[46]

Vascular endothelial growth factor (VEGF) *

-1.6

[47]

Urokinase plasminogen activator (uPA) *

-1.5

[48]

Human KIAA0628

-1.5

 

Asparagine synthetase

-1.5

 

Axl tyrosine kinase receptor *

-1.5

[49–51]

High mobility group isoform C (HMGI-C) *

-1.5

[52–54]

Lnk adaptor protein

-1.4

 

GTPase-activating protein ras p21 (RASA)

-1.4

 

Human KIAA0728 protein

-1.3

 

Axl tyrosine kinase receptor splice 2 *

-1.3

[49–51]

N-myristoyltransferase 2

-1.3

 

Caveolin 2 *

-1.3

[55]

Glycosylphosphatidylinositol-H (GPI-H)

-1.3

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