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Table 2 Summary of gene changes controlled by Rac1 and by Cdc42

From: Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts

Genes up-regulated   
Name Fold Change Reference
Ubiquitin Conjugating enzyme 12 (UBC12) * 6.4 [39]
Elongation factor-1 alpha-2 * 2.3 [40]
Guanine nucleotide-binding regulatory protein (G-y-alpha) 2.2  
mSin3A associated polypeptide p30 * 2.1 [41]
Rac protein kinase alpha 1.8  
Coupling protein G(s) alpha-subunit (alpha-S1) 1.8  
Histone H1x 1.8  
80K-L protein * 1.6 [42]
Killer cell lectin-like receptor, Subfam. C, member 2 (NKG2C) * 1.6 [43]
Alpha subunit of GsGTP binding protein 1.5  
Lipoprotein-associated coagulation inhibitor (LACI) 1.5  
ATP synthase alpha subunit 1.3  
Heat shock protein 70 (hsp70) * 1.3 [44]
Genes down-regulated   
Name Fold Change  
Insulin-like growth factor-binding protein-3 * -1.9 [45]
28s Ribosomal RNA gene -1.6  
Cyclooxygenase-2 (hCox-2) * -1.6 [46]
Vascular endothelial growth factor (VEGF) * -1.6 [47]
Urokinase plasminogen activator (uPA) * -1.5 [48]
Human KIAA0628 -1.5  
Asparagine synthetase -1.5  
Axl tyrosine kinase receptor * -1.5 [4951]
High mobility group isoform C (HMGI-C) * -1.5 [5254]
Lnk adaptor protein -1.4  
GTPase-activating protein ras p21 (RASA) -1.4  
Human KIAA0728 protein -1.3  
Axl tyrosine kinase receptor splice 2 * -1.3 [4951]
N-myristoyltransferase 2 -1.3  
Caveolin 2 * -1.3 [55]
Glycosylphosphatidylinositol-H (GPI-H) -1.3