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Table 1 Cox regression analysis of RFS based on manual and automated assessment of HMG-CoAR expression.

From: Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer

  Manual Analysis Autoscore Continuous Autoscore Dichotomised
  HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value
  Univariate   Univariate   Univariate  
HMG-CoAR
(high versus low)
0.52 (0.30-0.91) 0.022 0.98 (0.97 -- 0.99) 0.039 0.47 (0.25 -- 0.87) 0.017
Stage
(continuous)
2.17 (1.16-4.03) 0.015 2.17 (1.16 - 4.03) 0.015 2.17 (1.16 - 4.03) 0.015
Grade
(Low versus moderate and high)
1.32 (0.62-2.81) 0.471 1.32 (0.62 - 2.81) 0.471 1.32 (0.62 - 2.81) 0.471
Resdiual Disease
(no macrscopic disease v's macroscopic disease)
0.79 (0.35-1.81) 0.58 0.79 (0.35 - 1.81) 0.58 0.79 (0.35 - 1.81) 0.58
  Multivariate*   Multivariate*   Multivariate*  
HMG-CoAR
(high versus low)
0.52 (0.30-0.96) 0.036 0.99 (0.97 -- 0.99) 0.04 0.49 (0.25 -- 0.99) 0.03
Stage
(continuous)
1.31 (0.61-2.80) 0.485 1.33 (0.64-2.77) 0.447 1.40 (0.66 - 2.95) 0.373
Grade
(Low versus moderate and high)
2.03 (0.66-6.27) 0.216 1.15 (0.43-3.07) 0.777 1.28 (0.49 - 3.29) 0.61
Resdiual Disease
(no macrscopic disease v's macroscopic disease)
0.40 (0.12 1.29) 0.123 0.87 (0.53 - 1.45) 0.597 0.88 (0.53 - 1.50) 0.621