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Table 1 Tumor characteristics of three different inoculation approaches

From: Establishment and identification of a rabbit model of peritoneal carcinomatosis from gastric cancer

  Group A Group B Group C
Technical feature Laparotomic orthotopic
tumor cell injection into the gastric submucosa
Laparotomic orthotopic
tumor tissue inoculation beneath the gastric antrum
Percutaneous tumor cell injection into the peritoneum
Success rate 100% (12/12) 91.7% (11/12) 58.3% (7/12)
Major pathological events Rapid tumor progression resulting in respiratory distress syndrome, diffused peritonitis due to perforation of gastric tumor, intestinal obstruction, renal failure Rapid tumor progression resulting in intestinal obstruction, renal failure Rapid tumor progression resulting in intestinal adhesion an obstruction, renal failure
Gross pathology Ulcerative gastric cancer with PC, ascites Ulcerative gastric cancer with PC, ascites PC without gastric ulcer, ascites
Histopathology Penetrating growth of cancer cell nests invading surrounding structures, tumor necrosis in the central zone of the tumor mass   
Advantages Most resemble clinical gastric cancer with PC Technically less difficult Technically easy
Disadvantages Technically difficult Not exactly mimic gastric cancer with PC Mistaken injection into the intestines