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Table 1 Tumor characteristics of three different inoculation approaches

From: Establishment and identification of a rabbit model of peritoneal carcinomatosis from gastric cancer

 

Group A

Group B

Group C

Technical feature

Laparotomic orthotopic

tumor cell injection into the gastric submucosa

Laparotomic orthotopic

tumor tissue inoculation beneath the gastric antrum

Percutaneous tumor cell injection into the peritoneum

Success rate

100% (12/12)

91.7% (11/12)

58.3% (7/12)

Major pathological events

Rapid tumor progression resulting in respiratory distress syndrome, diffused peritonitis due to perforation of gastric tumor, intestinal obstruction, renal failure

Rapid tumor progression resulting in intestinal obstruction, renal failure

Rapid tumor progression resulting in intestinal adhesion an obstruction, renal failure

Gross pathology

Ulcerative gastric cancer with PC, ascites

Ulcerative gastric cancer with PC, ascites

PC without gastric ulcer, ascites

Histopathology

Penetrating growth of cancer cell nests invading surrounding structures, tumor necrosis in the central zone of the tumor mass

  

Advantages

Most resemble clinical gastric cancer with PC

Technically less difficult

Technically easy

Disadvantages

Technically difficult

Not exactly mimic gastric cancer with PC

Mistaken injection into the intestines