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Figure 5 | BMC Cancer

Figure 5

From: Cancer resistance of SR/CR mice in the genetic knockout backgrounds of leukocyte effector mechanisms: determinations for functional requirements

Figure 5

SR/CR Nos2 Knockout Macrophages and Neutrophils Have No Detectable Nitric Oxide Production Following LPS and IFNγ Stimulation. Thioglycolate elicited macrophages and neutrophils were stimulated with LPS and IFNγ for 24 hours. Nitrite levels, an indirect measure of nitric oxide production, were assessed by the Griess Assay. Nitrite levels for WT (n = 5) and SR/CR (n = 5) Nos2+/+ macrophages were comparable, but significant levels of nitrites were not detected (n.d.) in SR/CR Nos2-/- macrophages (n = 3). Nitrite levels for WT (n = 4) and SR/CR (n = 3) Nos2+/+ neutrophils were also comparable, but significant levels of nitrites were not detected in SR/CR Nos2-/- neutrophils (n = 3).

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