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Table 4 Possible associations between p16INK4A expression and clinicopathological parameters of colon cancer

From: Detection of HPV and the role of p16INK4Aoverexpression as a surrogate marker for the presence of functional HPV oncoprotein E7 in colorectal cancer

p16 expression

  

neg

%

weak

%

mod

%

strong

%

P

HPV

-

14

60.9

10

90.9

12

66.7

24

63.2

0.325

 

+

9

39.1

1

9.1

6

33.3

14

36.8

 

MSI

MSS

19

86.4

11

100.0

17

94.4

37

97.4

0.266

 

MSI

3

22.6

0

0.0

1

5.6

1

2.6

 

age (median)

 

63

 

70

 

66

 

65

 

0.344

gender

male

10

43.5

7

63.6

12

66.7

21

55.3

0.466

 

female

13

56.5

4

36.4

6

33.3

17

44.7

 

lymph nodes

-

9

60.0

6

66.7

6

66.7

24

68.6

0.951

 

+

6

40.0

3

33.3

12

33.3

11

31.4

 

grade of differentiation

good

12

54.5

7

63.6

8

44.4

18

51.4

0.875

 

moderate

7

31.8

3

27.3

9

50.0

13

37.1

 
 

poor

3

13.6

1

9.1

1

6.6

4

11.4

 

location

proximal

16

69.6

2

18.2

4

22.2

8

22.2

0.002

 

distal

2

8.7

3

27.3

9

50.0

16

44.4

 
 

rectum

5

21.7

6

54.5

5

27.8

12

33.3

 

stage

I

3

13.0

4

40.0

2

11.8

4

10.8

0.066

 

II

8

34.8

2

20.0

4

23.5

18

48.6

 
 

III

10

43.5

4

40.0

6

35.3

13

35.1

 
 

IV

2

8.7

0

0.0

5

29.4

2

5.4

 

adjuvant therapy

no

6

30.0

6

75.0

5

33.3

15

55.6

0.186

 

yes

14

70.0

2

25.0

10

66.7

12

44.4

 
  1. Possible associations were investigated using the χ2-test or Fisher's exact test (when appropriate) for categorical variables and using Student t-test or Mann-Whitney U test (when appropriate) for continuous variables (MSI: microsatellite instability, MSS: microsatellite stability).