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Figure 6 | BMC Cancer

Figure 6

From: Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

Figure 6

Lovastatin potentiates DNA damage and apoptosis induced by doxorubicin. A2780ADR cells were exposed to either a control, 10 μM lovastatin, 7 μM doxorubicin, or both 10 μM lovastatin and 7 μM doxorubicin together. A: Comet assays were performed and the olive tail moment determined for 75 cells of each condition. Data are presented as the mean of 4 independent experiments with error bars representing standard deviation. *, p < 0.05 compared to the untreated control by a Student's t-Test. TUNEL and PI dual-staining was carried out to determine the proportion of TUNEL-positive cells and if apoptotic cells originated predominantly in any particular phase of the cell cycle. B: Data are presented as the mean of 3 independent experiments measuring either TUNEL positivity (left) or PreG1 population (right) with error bars representing standard deviation. *, p < 0.05 compared to the untreated control by a Student's t-Test. C: Representative dot plots comparing the degree of TUNEL staining to DNA content. D: Schematic model illustrating two independent mechanisms of statin activity and the manner in which they can be combined to maximize clinical efficacy.

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