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Figure 5 | BMC Cancer

Figure 5

From: Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

Figure 5

Lovastatin increases doxorubicin retention in P-gp expressing ovarian cancer cells. A2780ADR (A) and CEMVBL (B) cells were treated with lovastatin and doxorubicin as indicated for 3 hours, with or without MVA. Intracellular doxorubicin fluorescence was measured by flow cytometry and the results are normalized to cells treated with doxorubicin alone (= 100%). Data are presented as the mean of 3-4 independent experiments with error bars representing standard deviation. Dashed line highlights the lack of reversal by MVA. *, p < 0.05 compared to the 100% control by a Student's t-Test. C: A2780ADR cells were incubated with a combination of 7 μM doxorubicin and 10 μM lovastatin for 3 hours and were further incubated for two hours in doxorubicin-free media, with or without 10 μM lovastatin. Intracellular doxorubicin was determined by flow cytometry and the results are normalized to cells co-treated with doxorubicin and lovastatin without further incubation (= 100%). Data are presented as the mean of 3 independent experiments with error bars representing standard deviation. *, p < 0.05 compared to the 100% control by a Student's t-Test.

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