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Figure 4 | BMC Cancer

Figure 4

From: Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

Figure 4

Lovastatin synergizes with doxorubicin in P-gp expressing ovarian cancer cells. A2780ADR (A) and CEMVBL (B) cells were plated for MTT assays and treated for 24 hours with concentration ranges of lovastatin and either doxorubicin or cisplatin. Combination index (CI) plots were generated using CalcuSyn software to determine whether the drugs synergize (CI < 1). Data is presented as the mean of 5-10 independently determined CI values with error bars representing standard deviation. *, p < 0.05 compared to additivity (CI = 1) by a Single Sample t-Test. C: Substantially higher P-gp expression was detected by flow cytometry in A2780ADR and CEMVBL cells compared to A2780 and CEM cells, respectively, using a fluorescence-tagged anti-P-gp antibody. The experiment was conducted 3 times; a representative histogram is shown.

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