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Table 4 Results of treatment in hypopharyngeal cancer with organ preservation approach

From: Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation

Author

Methods

No.

LCS (yr)

DFS (yr)

OS (yr)

LPS (yr)

Lefebvre[5]

Surgery

94

 

31% (3)

43% (3)

-

 

IC + RT

100

 

43% (3)

57% (3)

42% (3)

Zelefsky[8]

IC + RT

26

30% (5)

 

15% (5)

52% (5)

 

Surgery

30

42% (5)

 

22% (5)

 

Altundag[6]

IC + RT

45 total (5 hypo.)

50.9% (2)

  

63.3% (2)

Urba[7]

IC + RT

59 total (22 hypo.)

  

64% (3)

52% (3)

Lee [22]

CCRT

31 (11 hypo.)

94% (2)

86% (2)

63% (2)

89% (2)

Lefebvre[11]

IC + RT

224 (116 hypo.)

49.7% (3)

 

48.5% (5)

39.5% (5)

 

alternating

226 (115 hypo.)

50.6% (3)

 

51.9% (5)

45.4% (5)

This study

CCRT

27

63.0% (5)

51% (5)

34.8% (5)

59.2% (5)

  1. LCS: local control survival, DFS: disease-free survival, OS: overall survival, LPS: laryngeal preservation survival, IC: induction chemotherapy, RT: radiotherapy, hypo.: hypopharynx, HF-ACC-RCT: hyperfractionated accelerated radiochemotherapy, HF-ACC-RT: hyperfractionated accelerated radiotherapy, CCRT: concurrent chemoradiotheapy.