Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect - a histopathological and immunohistochemical study

Table 6 Results of Cox regression analysis for local recurrence, distant metastases and survival.

	tested variables	cell types		cell types/	TNM /
				inflamm.	infiltrate
		RR	95% CI	RR	95% CI
local recurrence	peritumoral mast cells
	- none/few	3.7	1.1 -12.8	1.9	0.5-7.1
	-moderate	1.3	0.4- 4.4	0.9	0.3-3.1
	- many	1.0		1.0
	inflammatory infiltrate
	-none/few	-		1.0
	-extensive			0.3	0.0-2.2
n = 148	TNM
33 events	- I/I I	-		1.0
	-III/IV			2.4	0.9-6.1
distant	peritumoral mast cells
metastases	- none/few	4.5	1.6-12.2	2.5	1.2-5.8
	- moderate	1.1	0.4-2.9	0.9	0.3-2.3
	- many	1.0		1.0
	intratumoral T cells (CD3)
	- none/few	3.2	1.5-6.8	2.6	1.2-5.8
	-moderate	2.0	0.9-4.1	1.8	0.8-3.8
	- many	1.0		1.0
	inflammatory infiltrate
	- none/few	-		1.0
	- extensive			1.0	0.4-2.9
n = 159	TNM
65 events	-I/II	-		1.0
	-III/IV			4.4	1.9-9.9
survival	peritumoral eosinophils
	- none/few	3.6	1.5-8.7	3.0	1.2-7.2
	-moderate	2.8	1.2-6.6	2.1	0.9-5.1
	- many	1.0		1.0
	peritumoral mast cells
	- none/few	2.9	1.2-6.8	1.4	0.6-3.4
	-moderate	0.8	0.4-1.9	0.6	0.3-1.4
	- many	1.0		1.0
	inflammatory infiltrate
	- none/few	-		1.0
	- extensive			1.0	0.4-2.5
n = 136	TNM
59 events	- I/II	-		1.0
	- III/IV			2.9	1.4-6.2

Cell types are included in the multivariate analysis if their p-value was less than 0.05 in the univariate analysis (table 3). Cell types are reported here and included in the multivariate analysis with TNM classification and inflammatory infiltrate, if they were significant in the Cox' regression of the cell types forward step-wise applied.

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