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Table 6 Results of Cox regression analysis for local recurrence, distant metastases and survival.

From: Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect - a histopathological and immunohistochemical study

  tested variables cell types cell types/ TNM /
     inflamm. infiltrate
   RR 95% CI RR 95% CI
local recurrence peritumoral mast cells     
  - none/few 3.7 1.1 -12.8 1.9 0.5-7.1
  -moderate 1.3 0.4- 4.4 0.9 0.3-3.1
  - many 1.0   1.0  
  inflammatory infiltrate     
  -none/few -   1.0  
  -extensive    0.3 0.0-2.2
n = 148 TNM     
33 events - I/I I -   1.0  
  -III/IV    2.4 0.9-6.1
distant peritumoral mast cells     
metastases - none/few 4.5 1.6-12.2 2.5 1.2-5.8
  - moderate 1.1 0.4-2.9 0.9 0.3-2.3
  - many 1.0   1.0  
  intratumoral T cells (CD3)     
  - none/few 3.2 1.5-6.8 2.6 1.2-5.8
  -moderate 2.0 0.9-4.1 1.8 0.8-3.8
  - many 1.0   1.0  
  inflammatory infiltrate     
  - none/few -   1.0  
  - extensive    1.0 0.4-2.9
n = 159 TNM     
65 events -I/II -   1.0  
  -III/IV    4.4 1.9-9.9
survival peritumoral eosinophils     
  - none/few 3.6 1.5-8.7 3.0 1.2-7.2
  -moderate 2.8 1.2-6.6 2.1 0.9-5.1
  - many 1.0   1.0  
  peritumoral mast cells     
  - none/few 2.9 1.2-6.8 1.4 0.6-3.4
  -moderate 0.8 0.4-1.9 0.6 0.3-1.4
  - many 1.0   1.0  
  inflammatory infiltrate     
  - none/few -   1.0  
  - extensive    1.0 0.4-2.5
n = 136 TNM     
59 events - I/II -   1.0  
  - III/IV    2.9 1.4-6.2
  1. Cell types are included in the multivariate analysis if their p-value was less than 0.05 in the univariate analysis (table 3). Cell types are reported here and included in the multivariate analysis with TNM classification and inflammatory infiltrate, if they were significant in the Cox' regression of the cell types forward step-wise applied.