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Table 5 Results of univariate log rank analyses for the risk on local recurrence, the risk on distant metastases and the survival.

From: Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect - a histopathological and immunohistochemical study

   local recurrence % distant metastases % cumulative survival %
   (2 year) (2 year) (2 year)
cell type   none/few moderate many p-value none/few moderate many p-value none/few moderate many p-value
eosinophils              
  intratumoral 18 26 34 0.45 30 54 56 0.08 72 67 62 0.94
  peritumoral 42 24 14 0.007* 62 48 35 0.009* 56 65 83 0.0008*
neutrophils              
  intratumoral 35 23 23 0.42 46 49 47 0.85 61 68 73 0.66
  peritumoral 44 - 22 0.02* 52 - 48 0.88 48 - 72 0.19
mast cells              
  intratumoral 42 23 20 0.17 65 47 39 0.08 45 74 71 0.006*
  peritumoral 44 18 15 0.007* 86 38 21 <0.0001* 43 78 73 <0.0001*
macrophages              
  intratumoral 41 25 9 0.03* 63 50 28 0.03* 56 70 75 0.006*
  peritumoral 27 21 17 0.70 54 31 20 0.007* 70 68 67 0.50
NK cells              
  intratumoral 36 - 20 0.03* 50 - 47 0.58 57 - 73 0.15
  peritumoral 27> - 23 0.65 52 - 40 0.22 68 - 68 0.87
T cells (CD3)              
  intratumoral 35 29 13 0.08 76 42 32 <0.0001* 57 67 75 0.002*
  peritumoral 25 23 25 0.67 63 41 47 0.02* 60 70 69 0.17
CD4 T cells              
  intratumoral 33 31 10 0.01* 48 47 46 0.55 66 60 78 0.21
  peritumoral 36 28 14 0.10 54 53 46 0.90 66 65 70 0.51
CD8 T cells              
  intratumoral 34 22 22 0.19 71 42 37 0.0005* 58 73 69 0.01*
  peritumoral 27 - 20 0.11 58 - 19 0.002* 60 - 86 0.05
  1. The marked cell types (*) show a significant correlation with prognosis. Median follow up is 35.4 months, n = 160