Table 1 Summary of alterations of E-cadherin and β-catenin in a series of 50 gastric tumours.
From: Alterations of E-cadherin and β-catenin in gastric cancer
Tumour | Stage | Type | Grade | LOH | E-cad gene mutations | Aberrant mRNA | E-cad | β-cat |
|---|---|---|---|---|---|---|---|---|
Sample | at 16q22.1 | and polymorphisms | of E-cad | IHC | IHC | |||
1 | T3N3 | diff | + | IVS1+6T→C | - | +/- | ++/-∇ | |
3 | T3N1 | squ | G1 | + | IVS4+10C→G | ND | - | +/- |
17 | T3N1 | diff | ND | GTG(Val)→GTC(Val) at cd832 | ND | - | - | |
23 | met | + | GCC(Ala)→ACC(Thr) at cd592* | ND | +++/- | +++/- | ||
43 | T3N2 | diff | + | - | - | - | +++/- | |
50 | T3N1 | diff | - | IVS1+6T→C | - | ++/- | ++/- | |
165 | T3N1 | int | G3 | ND | - | - | +++/- | +++/-∇ |
174 | T3N2 | int | G3 | - | - | ND | +++/- | ++/- |
193 | T3N2 | int | G3 | + | - | ND | -/+++ | -/++ |
200 | T3N1 | int | G2 | - | IVS4+10C→G | - | ++/- | +++/- |
231 | T3N0 | mi | G3 | + | - | - | ++/- | ++/-∇ |
283 | T3N0 | int | G3 | ND | - | ND | ++/- | ++/- |
287 | T3N1 | int | G2 | + | - | - | -/+ | ++/- |
294 | T3N1M1 | mi | G4 | + | GCC(Ala)→ACC(Thr) at cd592♦ | - | ++/- | ++/-∇ |
304 | T3N3 | int | G2 | - | - | - | -/+++ | +/- |
308 | T3N1 | int | G2 | + | - | - | +++/- | ++/- |
314 | T3N1 | diff | - | CAC(His)→CAT(His) at cd632 | - | +++/- | ++/-∇ | |
GGC(Gly)→GGT(Gly) at cd865 | ||||||||
360 | T2N1 | int | G3 | + | IVS4+10C→G | +♣ | ++/- | +/- |
369 | met | + | - | +♣ | +++/- | ++/- | ||
433 | T3N1 | mi | G3 | - | IVS4+10C→G | - | -/++ | -/+ |
435 | T2N0 | int | G3 | + | - | - | -/+++ | -/++ |
443 | T2N0 | int | G4 | - | - | - | +++/- | +++/- |
451 | T4N0 | int | G2 | ND | - | ND | +++/- | ++/- |
474 | T3N1 | int | G3 | ND | - | ND | - | +/- |
493 | T3N1 | int | G3 | + | - | - | -/+++ | +/- |
503 | T3N1 | int | G3 | ND | - | - | - | +++/- |
556 | T3N2 | int | G2 | - | IVS1+6T→C | ND | ++/- | +/- |
5'UTR-71C→G | ||||||||
568 | T3N2 | mi | G3 | + | - | +♣ | ++/- | ++/- |
612 | T3N0 | int | G2 | ND | IVS4+10C→G | - | +++/- | +/- |
AAC(Asn)→AAT(Asn) at cd751 | ||||||||
636 | T3N1 | diff | + | IVS4+10C→G | ND | +++/- | +++/-∇ | |
650 | T2N0M1 | int | G2 | + | - | ND | -/+ | ++/- |
675 | T2N0 | mi | G3 | + | IVS4+10C→G | - | +/- | ++/-∇ |
676 | T3N1 | int | G2 | + | - | - | +++/- | -∇ |
680 | T3N1 | mi | G3 | + | IVS1+6T→C | - | ++/- | ++/- |
AAC(Asn)→AAT(Asn) at cd751 | ||||||||
694 | T3N1 | int | G1 | + | - | - | +++/- | +++/- |
717 | T3N1 | int | G3 | + | - | +♣ | -/+++ | +++/- |
726 | T2N1 | int | G2 | + | IVS4+10C→G | - | -/+++ | ++/- |
728 | T3N0 | int | G2 | + | GCC(Ala)→ACC(Thr) at cd592♦ | - | -/+++ | ++/- |
729 | T3N1 | int | G1 | - | IVS1+6T→C | - | -/+++ | +++/- |
732 | T2N1 | int | G3 | + | - | - | -/+++ | +++/- |
735 | T4N3 | diff | ND | AAC(Asn)→AAT(Asn) at cd751 | - | +++/- | +++/-∇ | |
738 | T3N2 | diff | + | - | - | - | -∇ | |
750 | met | ND | AAC(Asn)→AAT(Asn) at cd751 | +♣ | ++/- | +++/- | ||
755 | T2N1 | int | G2 | ND | - | +♥ | +++/- | ++/- |
808 | T3N0 | int | G1 | + | ACG(Thr)→ACA(Thr) at cd251 | +♠ | +++/- | ++/- |
811 | T2N1 | int | G2 | + | - | - | +++/- | -/+ |
832 | T3N2 | int | G2 | + | - | - | +++/- | +++/-∇ |
855 | T3N2 | int | G2 | + | - | - | +++/- | +++/- |
875 | T3N2 | int | G2 | - | IVS4+10C→G | ND | +++/- | +++/- |
904 | T2N0 | int | G3 | + | IVS4+10C→G | - | -/+++ | ++/- |
Useful | 30 | 3 | 7 | 21 | 14 | |||
Total | 40 | 50 | 38 | 50 | 50 | |||
% | 75 | 6 | 18 | 42 | 28 |