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Table 1 Effect of dietary curcumin on expression levels of c-Ha-ras (p21) and c-fos (p62) in skin of DMBA and TPA treated animals (N = 20).

From: Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin

Condition

Ras (Arbitary unit)

Fos (Arbitary unit)

 

T

N

T

N

Control

8.74 ± 1.7

0.17 ± 0.1

5.8 ± 0.8

0.8 ± 0.5

 

(100%)

(1.94%)

(100%)

(13.8%)

0.2%Curcumin

5.30 ± 2.2

0.15 ± 0.05

3.6 ± 0.9

0.9 ± 0.15

 

(60.6%)

(1.72%)

(62.1%)

(15.5%)

1%Curcumin

2.73 ± 1.1

0.07 ± 0.05

2.0 ± 0.6

0

 

(31.2%)

(0.8%)

(34.5%)

(0%)

  1. T = Tumorous skin N = Non-tumorous skin aResults are expressed as arbitary unit; values are mean ± SD. bValues in parentheses relatively represent percentage of ras or fos gene expression. The levels of ras and fos proteins in the control diet are represented as 100%.
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BMC Cancer

ISSN: 1471-2407

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