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  1. The prevalence of programmed death-ligand 1 (PD-L1) and PD-L2 expression on tumor cells and tumor-infiltrating immune cells in primary central nervous system lymphoma (PCNSL) remains unclear. In the present st...

    Authors: Motomasa Furuse, Hiroko Kuwabara, Naokado Ikeda, Yasuhiko Hattori, Tomotsugu Ichikawa, Naoki Kagawa, Kenichiro Kikuta, Sho Tamai, Mitsutoshi Nakada, Toshihiko Wakabayashi, Masahiko Wanibuchi, Toshihiko Kuroiwa, Yoshinobu Hirose and Shin-Ichi Miyatake

    Citation: BMC Cancer 2020 20:277

    Content type: Research article

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  2. To evaluate the value of new therapies for non-small cell lung cancer (NSCLC), it is necessary to understand overall survival (OS) rates associated with previous standard therapies and how these rates have evo...

    Authors: Ryan N. Hansen, Yiduo Zhang, Brian Seal, Kellie Ryan, Candice Yong, Annie Darilay and Scott D. Ramsey

    Citation: BMC Cancer 2020 20:276

    Content type: Research article

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  3. Detection of epidermal growth factor receptor (EGFR) mutations in exons 18–21 is recommended in all patients with advanced Non-small-cell lung carcinoma due to the demonstrated efficiency of the standard therapy ...

    Authors: Mercedes Delgado-García, Birgit Weynand, Lourdes Gómez-Izquierdo, María José Hernández, Ángela María Blanco, Mar Varela, Xavier Matias-Guiu, Ernest Nadal, Bélgica Márquez-Lobo, Ana Alarcão, Enrique de Álava and Michele Biscuola

    Citation: BMC Cancer 2020 20:275

    Content type: Research article

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  4. Lymphovascular invasion (LVI) has never been revealed by preoperative scans. It is necessary to use digital mammography in predicting LVI in patients with breast cancer preoperatively.

    Authors: Zhuangsheng Liu, Ruqiong Li, Keming Liang, Junhao Chen, Xiangmeng Chen, Xiaoping Li, Ronggang Li, Xin Zhang, Lilei Yi and Wansheng Long

    Citation: BMC Cancer 2020 20:274

    Content type: Research article

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  5. Clear cell renal cell carcinoma (ccRCC) is a markedly heterogeneous disease in many aspects, including the tumour microenvironment. Our previous study showed the importance of the tumour microenvironment in cc...

    Authors: Ju-Yoon Yoon, Craig Gedye, Joshua Paterson and Laurie Ailles

    Citation: BMC Cancer 2020 20:272

    Content type: Research article

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  6. Metastatic pancreatic cancer has a median overall survival of less than 12 months, even if treated with chemotherapy. Selected patients with oligometastatic disease could benefit from multimodal treatments con...

    Authors: D. M. Filippini, E. Grassi, A. Palloni, R. Carloni, R. Casadei, C. Ricci, C. Serra, G. Ercolani, G. Brandi and M. Di Marco

    Citation: BMC Cancer 2020 20:271

    Content type: Case report

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  7. In the past four decades, the incidence of cholangiocarcinoma, especially intrahepatic cholangiocarcinoma (ICC), has raised rapidly worldwide. Completeness of resection, max size of tumor and etc. are widely r...

    Authors: Zeyu Zhang, Yufan Zhou, Kuan Hu, Dong Wang, Zhiming Wang and Yun Huang

    Citation: BMC Cancer 2020 20:270

    Content type: Research article

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  8. Multiple myeloma (MM) remains incurable despite recent therapeutic advances. RAS mutations are frequently associated with relapsed/refractory disease. Efforts to target the mitogen-activated protein kinase (MA...

    Authors: Priya Sriskandarajah, Alexis De Haven Brandon, Kenneth MacLeod, Neil O. Carragher, Vladimir Kirkin, Martin Kaiser and Steven R. Whittaker

    Citation: BMC Cancer 2020 20:269

    Content type: Research article

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  9. Clinical outcomes of patients with osteosarcoma remain unsatisfactory, with little improvement in a 5-year overall survival over the past three decades. There is a substantial need for further research and dev...

    Authors: Nut Koonrungsesomboon, Nuttapong Ngamphaiboon, Natavudh Townamchai, Pimpisa Teeyakasem, Chaiyut Charoentum, Pimlak Charoenkwan, Rungrote Natesirinilkul, Lalita Sathitsamitphong, Touch Ativitavas, Parunya Chaiyawat, Jeerawan Klangjorhor, Suradej Hongeng and Dumnoensun Pruksakorn

    Citation: BMC Cancer 2020 20:268

    Content type: Study protocol

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  10. Colon cancer is one of the most common malignancies and the fourth leading cause of cancer-related mortality in the world. Colibactin, which is synthesized by the pks genomic island of E. coli interfere with the ...

    Authors: Faezah Kosari, Mohammad Taheri, Abbas Moradi, Reza Hakimi Alni and Mohammad Yousef Alikhani

    Citation: BMC Cancer 2020 20:267

    Content type: Research article

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  11. Lymphovascular invasion (LOI), a key pathological feature of head and neck squamous cell carcinoma (HNSCC), is predictive of poor survival; however, the associated clinical characteristics and underlying molec...

    Authors: Jian Zhang, Huaming Lin, Huali Jiang, Hualong Jiang, Tao Xie, Baiyao Wang, Xiaoting Huang, Jie Lin, Anan Xu, Rong Li, Jiexia Zhang and Yawei Yuan

    Citation: BMC Cancer 2020 20:266

    Content type: Research article

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  12. Infiltrating immune and stromal cells are vital components of the bladder cancer (BC) microenvironment, which can significantly affect BC progression and outcome. However, the contribution of each subset of tu...

    Authors: Ye Zhang, De-hua Ou, Dong-wu Zhuang, Ze-feng Zheng and Ming-en Lin

    Citation: BMC Cancer 2020 20:265

    Content type: Research article

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  13. The human pancreatic cancer cell line A818–6 can be grown in vitro either as a highly malignant, undifferentiated monolayer (ML) or as three-dimensional (3D) single layer hollow spheres (HS) simulating a benig...

    Authors: Doaa Tawfik, Angela Zaccagnino, Alexander Bernt, Monika Szczepanowski, Wolfram Klapper, Albrecht Schwab, Holger Kalthoff and Anna Trauzold

    Citation: BMC Cancer 2020 20:264

    Content type: Research article

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  14. Cancer survivors and their caregivers may have various unmet needs that are medically difficult to solve. Previous studies have suggested the relations between individuals’ backgrounds and their unmet needs. W...

    Authors: Kaname Watanabe, Kayoko Katayama, Takashi Yoshioka and Hiroto Narimatsu

    Citation: BMC Cancer 2020 20:263

    Content type: Research article

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  15. Chromodomain helicase DNA-binding protein 4 (CHD4) has been shown to contribute to DNA repair and cell cycle promotion; however, its roles in cancer initiation and progression remain largely unknown. This stud...

    Authors: Nuo Xu, Fanglei Liu, Shengdi Wu, Maosong Ye, Haiyan Ge, Meiling Zhang, Yuanlin Song, Lin Tong, Jian Zhou and Chunxue Bai

    Citation: BMC Cancer 2020 20:262

    Content type: Research article

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  16. The objective of this study was to describe the real-world treatment and overall survival (OS) of German patients with a diagnosis of advanced non-small cell lung cancer (aNSCLC), and to explore factors associ...

    Authors: Fränce Hardtstock, David Myers, Tracy Li, Diana Cizova, Ulf Maywald, Thomas Wilke and Frank Griesinger

    Citation: BMC Cancer 2020 20:260

    Content type: Research article

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  17. Combination of gemcitabine and nab-paclitaxel has superior clinical efficacy than gemcitabine alone. Nevertheless, health-related quality of life. (QoL) associated with this combination therapy when administer...

    Authors: Suayib Yalcin, Faysal Dane, Berna Oksuzoglu, Nuriye Yildirim Ozdemir, Abdurrahman Isikdogan, Metin Ozkan, Guzin Gonullu Demirag, Hasan Senol Coskun, Bulent Karabulut, Turkkan Evrensel, Mehmet Ali Ustaoglu, Feyyaz Ozdemir, Hande Turna, Tugba Yavuzsen, Faruk Aykan, Alper Sevinc…

    Citation: BMC Cancer 2020 20:259

    Content type: Research article

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  18. Melanoma is the most aggressive skin cancer that derived from pigment cells, accounting for the majority of the skin-cancer-related deaths. Despite great development and evolution have been made in surgery, ra...

    Authors: Fei Liu, Lanting Hu, Yi Pei, Ke Zheng, Wei Wang, Shenglong Li, Enduo Qiu, Guanning Shang, Jiaming Zhang and Xiaojing Zhang

    Citation: BMC Cancer 2020 20:258

    Content type: Research article

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  19. Li-Fraumeni syndrome is a cancer predisposition syndrome caused by germline TP53 tumor suppressor gene mutations, with no previous association with pancreatic neuroendocrine tumors (PNETs). Here we present the fi...

    Authors: John G. Aversa, Francine Blumental De Abreu, Sho Yano, Liqiang Xi, Donald W. Hadley, Irini Manoli, Mark Raffeld, Samira M. Sadowski and Naris Nilubol

    Citation: BMC Cancer 2020 20:256

    Content type: Case report

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  20. The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab plus chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to trastuzumab is unknown.

    Authors: Fan Yang, Xiang Huang, Chunxiao Sun, Jianbin Li, Biyun Wang, Min Yan, Feng Jin, Haibo Wang, Jin Zhang, Peifen Fu, Tianyu Zeng, Jian Wang, Wei Li, Yongfei Li, Mengzhu Yang, Jun Li…

    Citation: BMC Cancer 2020 20:255

    Content type: Research article

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  21. In high-income countries (HICs), increased rates of survival among pediatric cancer patients are achieved through the use of protocol-driven treatment. Compared to HICs, differences in infrastructure, supporti...

    Authors: Lavanya Vasudevan, Kristin Schroeder, Yadurshini Raveendran, Kunal Goel, Christina Makarushka, Nestory Masalu and Leah L. Zullig

    Citation: BMC Cancer 2020 20:254

    Content type: Study protocol

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  22. Various tumor characteristics might lead to inaccurate local MRI-defined stage of rectal cancer and the purpose of this study was to explore the clinicopathological factors that impact on the precision pre-tre...

    Authors: Zerong Cai, Xiaoyu Xie, Yufeng Chen, Zexian Chen, Wuteng Cao, Khamis Salem Saeed Saad, Yifeng Zou, Ping Lan and Xiaojian Wu

    Citation: BMC Cancer 2020 20:253

    Content type: Research article

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  23. Colorectal cancer (CRC) cases are detected late in Malaysia similar to most Asian countries. The Be Cancer Alert Campaign (BCAC) was a culturally adapted mass media campaign designed to improve CRC awareness and ...

    Authors: Désirée Schliemann, Darishiani Paramasivam, Maznah Dahlui, Christopher R. Cardwell, Saunthari Somasundaram, Nor Saleha Binti Ibrahim Tamin, Conan Donnelly, Tin Tin Su and Michael Donnelly

    Citation: BMC Cancer 2020 20:252

    Content type: Research article

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  24. Invasive urothelial carcinoma (iUC) is highly similar between dogs and humans in terms of pathologic presentation, molecular subtypes, response to treatment and age at onset. Thus, the dog is an established an...

    Authors: Heidi G. Parker, Deepika Dhawan, Alex C. Harris, Jose A. Ramos-Vara, Brian W. Davis, Deborah W. Knapp and Elaine A. Ostrander

    Citation: BMC Cancer 2020 20:251

    Content type: Research article

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  25. It is evident that comorbidity exacerbate the complexity of the management of lung cancer, however, limited research has been conducted to investigate the impact of comorbidity on health service utilization an...

    Authors: Ruoxi Ding, Dawei Zhu, Ping He, Yong Ma, Zhishui Chen and Xuefeng Shi

    Citation: BMC Cancer 2020 20:250

    Content type: Research article

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  26. No study has evaluated C-reactive protein (CRP) and plasma albumin (PA) levels longitudinally in patients with acute myeloid leukaemia (AML).

    Authors: Kim Oren Gradel, Pedro Póvoa, Olav Sivertsen Garvik, Pernille Just Vinholt, Stig Lønberg Nielsen, Thøger Gorm Jensen, Ming Chen, Ram Benny Dessau, Jens Kjølseth Møller, John Eugenio Coia, Pernille Sanberg Ljungdalh, Annmarie Touborg Lassen and Henrik Frederiksen

    Citation: BMC Cancer 2020 20:249

    Content type: Research article

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  27. This study was designed to investigate the clinicopathologic features of pulmonary blastomatoid carcinosarcoma and explore the genomic profiles of epithelial and mesenchymal components in this tumor.

    Authors: Jikai Zhao, Chan Xiang, Ruiying Zhao, Ping Guo, Jingjing Zheng, Han Han-Zhang, Keke Yu, Jie Zhang and Yuchen Han

    Citation: BMC Cancer 2020 20:248

    Content type: Research article

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  28. Increased knowledge of breast cancer risk factors has meant that we are currently exploring risk-based screening, i.e. determining screening strategies based on women’s varying levels of risk. This also enable...

    Authors: Linda Rainey, Daniëlle van der Waal, Anna Jervaeus, Louise S. Donnelly, D. Gareth Evans, Mattias Hammarström, Per Hall, Yvonne Wengström and Mireille J. M. Broeders

    Citation: BMC Cancer 2020 20:247

    Content type: Research article

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  29. Approximately one third of all patients with CRC present with, or subsequently develop, colorectal liver metastases (CRLM). The objective of this population-based analysis was to assess the impact of resection...

    Authors: Alexander R. Siebenhüner, Ulrich Güller and Rene Warschkow

    Citation: BMC Cancer 2020 20:246

    Content type: Research article

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  30. Patients with multiple myeloma report more problems with quality of life (QoL) than other haematological malignancies over the course of their incurable illness. The patient-centred Myeloma Patient Outcome Sca...

    Authors: Christina Gerlach, Katherine Taylor, Marion Ferner, Markus Munder, Martin Weber and Christina Ramsenthaler

    Citation: BMC Cancer 2020 20:245

    Content type: Research article

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  31. Pregnancy-associated breast cancer (PABC) is an aggressive disease, and since Chinese authority began to encourage childbearing in 2015, the incidence of PABC has increased. This study investigated the charact...

    Authors: Bo-yue Han, Xiao-guang Li, Hai-yun Zhao, Xin Hu and Hong Ling

    Citation: BMC Cancer 2020 20:244

    Content type: Research article

    Published on:

  32. Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this d...

    Authors: Fangbin Zhou, Donge Tang, Yong Xu, Huiyan He, Yan Wu, Liewen Lin, Jun Dong, Wenyong Tan and Yong Dai

    Citation: BMC Cancer 2020 20:242

    Content type: Research article

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  33. Locally advanced nasopharyngeal carcinoma (LA-NPC) is a relatively rare disease in the west but more common in East Asia and areas of the Middle East like Saudi Arabia. Despite the advances in radiation therap...

    Authors: Nasser Al-Rajhi, Hussein Soudy, Shoaib A. Ahmed, Tusneem Elhassan, Shamayel F. Mohammed, Hatim A. Khoja and Hazem Ghebeh

    Citation: BMC Cancer 2020 20:240

    Content type: Research article

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  34. The identification of neck lymph node (LN) metastases represents a very important issue in the management of patients with differentiated thyroid carcinoma (DTC). To this purpose, in the present study, we used...

    Authors: Angela Spanu, Susanna Nuvoli, Andrea Marongiu, Ilaria Gelo, Luciana Mele, Bastiana Piras and Giuseppe Madeddu

    Citation: BMC Cancer 2020 20:239

    Content type: Research article

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  35. Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigate...

    Authors: Hualin Song, Song Jin, Peng Xiang, Shuai Hu and Jie Jin

    Citation: BMC Cancer 2020 20:238

    Content type: Research article

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  36. Treatment resistance is a major clinical challenge of diffuse large B-cell lymphoma (DLBCL) where approximately 40% of the patients have refractory disease or relapse. Since DLBCL is characterized by great cli...

    Authors: Hanne Due, Rasmus Froberg Brøndum, Ken H. Young, Martin Bøgsted and Karen Dybkær

    Citation: BMC Cancer 2020 20:237

    Content type: Research article

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  37. The relationship of neutrophil/lymphocyte ratio (NLR) to prognosis of HER2-positive breast cancer (BC) is not well studied. We aimed to assess the prognostic role of NLR in HER2-positive BC patients treated wi...

    Authors: Nianhua Ding, Juan Huang, Ningsha Li, Jiaqi Yuan, Shouman Wang and Zhi Xiao

    Citation: BMC Cancer 2020 20:235

    Content type: Research article

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  38. Despite conflicting results, considerable evidence suggests the association between single nucleotide polymorphisms in MTHFR, XRCC1 and OGG1 genes and, risk of developing breast cancer. Here a case-control study ...

    Authors: Matteo Floris, Daria Sanna, Paolo Castiglia, Carlo Putzu, Valeria Sanna, Antonio Pazzola, Maria Rosaria De Miglio, Francesca Sanges, Giovanna Pira, Antonio Azara, Emanuele Lampis, Antonello Serra, Ciriaco Carru, Maristella Steri, Flavia Costanza, Marco Bisail…

    Citation: BMC Cancer 2020 20:234

    Content type: Research article

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  39. NEPA is an oral fixed-dose combination of netupitant, a new highly selective neurokinin-1 receptor antagonist, and palonosetron. This study was conducted to evaluate whether the efficacy of NEPA against chemot...

    Authors: Roberta Caputo, Marina Elena Cazzaniga, Andrea Sbrana, Rosalba Torrisi, Ida Paris, Monica Giordano, Vincenzo Montesarchio, Valentina Guarneri, Laura Amaducci, Domenico Bilancia, Giuseppina Cilenti, Alessandra Fabi, Elena Collovà, Alessio Schirone, Erminio Bonizzoni, Luigi Celio…

    Citation: BMC Cancer 2020 20:232

    Content type: Research article

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  40. Prophylactic cranial irradiation (PCI) is a current standard of care after confirmed response to radical chemoradiotherapy for limited disease small cell lung cancer (LD-SCLC). This standard is mostly based on...

    Authors: Sergiusz Nawrocki and Anna Sugajska

    Citation: BMC Cancer 2020 20:231

    Content type: Study protocol

    Published on:

  41. Immune checkpoint inhibitors (ICI) are an integral part of bladder cancer therapy, however, the relevance of ICI treatment for mixed and pure squamous cell carcinoma of the bladder remains poorly studied. Ther...

    Authors: Ronja Morsch, Michael Rose, Angela Maurer, Maria Angela Cassataro, Till Braunschweig, Ruth Knüchel, Thomas-Alexander Vögeli, Thorsten Ecke, Markus Eckstein, Veronika Weyerer, Irene Esposito, Maximilian Ackermann, Günter Niegisch and Nadine T. Gaisa

    Citation: BMC Cancer 2020 20:230

    Content type: Research article

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  42. Simeoni and colleagues introduced a compartmental model for tumor growth that has proved quite successful in modeling experimental therapeutic regimens in oncology. The model is based on a system of ordinary d...

    Authors: James A. Koziol, Theresa J. Falls and Jan E. Schnitzer

    Citation: BMC Cancer 2020 20:226

    Content type: Technical advance

    Published on:

  43. Considering the potential of p16 as a marker for diagnosis, prognosis and therapeutic response, the aim of this study was to assess its presence, via immunocytochemistry, in metastatic carcinoma of different p...

    Authors: Fabiana Pirani Carneiro, Rivadávio Fernandes Amorim, Marcos de Vasconcelos Carneiro, Tercia Maria Mendes Lousa de Castro, Leonora Maciel de Souza Vianna, Gustavo Henrique Soares Takano, Andersen Charles Daros, Isabela Peres, Selma Aparecida Souza Kuckelhaus and Andrea Barretto Motoyama

    Citation: BMC Cancer 2020 20:225

    Content type: Research article

    Published on:

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