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  1. Case report

    Case report: rapid and durable response to PDGFR targeted therapy in a child with refractory multiple infantile myofibromatosis and a heterozygous germline mutation of the PDGFRB gene

    Infantile myofibromatosis belongs to a family of soft tissue tumors. The majority of these tumors have benign behavior but resistant and malignant courses are known, namely in tumors with visceral involvement....

    Peter Mudry, Ondrej Slaby, Jakub Neradil, Jana Soukalova, Kristyna Melicharkova, Ondrej Rohleder, Marta Jezova, Anna Seehofnerova, Elleni Michu, Renata Veselska and Jaroslav Sterba

    BMC Cancer 2017 17:119

    Published on: 10 February 2017

  2. Research article

    Supporting adherence to oral anticancer agents: clinical practice and clues to improve care provided by physicians, nurse practitioners, nurses and pharmacists

    Healthcare provider (HCP) activities and attitudes towards patients strongly influence medication adherence. The aim of this study was to assess current clinical practices to support patients in adhering to tr...

    Lonneke Timmers, Christel C. L. M. Boons, Mathieu Verbrugghe, Bart J. F. van den Bemt, Ann Van Hecke and Jacqueline G. Hugtenburg

    BMC Cancer 2017 17:122

    Published on: 10 February 2017

  3. Research article

    Photodynamic therapy combined to cisplatin potentiates cell death responses of cervical cancer cells

    Photodynamic therapy (PDT) has proven to be a promising alternative to current cancer treatments, especially if combined with conventional approaches. The technique is based on the administration of a non-toxi...

    Laura Marise de Freitas, Rodolfo Bortolozo Serafim, Juliana Ferreira de Sousa, Thaís Fernanda Moreira, Cláudia Tavares dos Santos, Amanda Martins Baviera, Valeria Valente, Christiane Pienna Soares and Carla Raquel Fontana

    BMC Cancer 2017 17:123

    Published on: 10 February 2017

  4. Research article

    Inhibition of glioblastoma dispersal by the MEK inhibitor PD0325901

    Dispersal of glioblastoma (GBM) cells leads to recurrence and poor prognosis. Accordingly, molecular pathways involved in dispersal are potential therapeutic targets. The mitogen activated protein kinase/extra...

    Stephen Shannon, Dongxuan Jia, Ildiko Entersz, Paul Beelen, Miao Yu, Christian Carcione, Jonathan Carcione, Aria Mahtabfar, Connan Vaca, Michael Weaver, David Shreiber, Jeffrey D. Zahn, Liping Liu, Hao Lin and Ramsey A. Foty

    BMC Cancer 2017 17:121

    Published on: 10 February 2017

  5. Research article

    Enhanced and long term immunogenicity of a Her-2/neu multi-epitope vaccine conjugated to the carrier CRM197 in conjunction with the adjuvant Montanide

    We previously identified three short single peptides (P4, P6 and P7) representing different B-cell epitopes on the extracellular domain of Her-2/neu for a vaccine that was tested in a phase-I clinical trial. H...

    Joshua Tobias, Joanna Jasinska, Karin Baier, Michael Kundi, Nicholas Ede, Christoph Zielinski and Ursula Wiedermann

    BMC Cancer 2017 17:118

    Published on: 9 February 2017

  6. Research article

    Low CCL17 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma

    Chemokine (C–C motif) ligand 17 (CCL17) is a chemokine mainly produced by myeloid dendritic cells. It is a ligand for CC chemokine receptor 4 (CCR4) and CC chemokine receptor 8 (CCR8). The aim of this study wa...

    Ying Xiong, Li Liu, Yu Xia, Jiajun Wang, Wei Xi, Qi Bai, Yang Qu, Jiejie Xu and Jianming Guo

    BMC Cancer 2017 17:117

    Published on: 8 February 2017

  7. Research article

    Treatment patterns and survival in an exhaustive French cohort of pazopanib-eligible patients with metastatic soft tissue sarcoma (STS)

    The French EMS study prospectively collected exhaustive data from STS patients diagnosed in the Rhone-Alpes region from 2005 to 07.

    Isabelle Ray-Coquard, Olivier Collard, Françoise Ducimetiere, Mathieu Laramas, Florence Mercier, Nadine Ladarre, Stephanie Manson, Bertrand Tehard, Sébastien Clippe, Jean-Philippe Suchaud, Laetitia Stefani and Jean-Yves Blay

    BMC Cancer 2017 17:111

    Published on: 7 February 2017

  8. Research article

    Immunohistochemical determination of estrogen and progesterone receptors in breast cancer: relationship with clinicopathologic factors in 302 patients in Ivory Coast

    Breast cancer is a heterogeneous and a hormone-dependent disease. The detection of the estrogen receptor (ER) and progesterone receptor (PgR) is crucial for prognostic evaluation and treatment choice of breast...

    Ahoua Benjamin Effi, Nguiessan Alphonse Aman, Baumaney Sylvanus Koui, Kouadio Donatien Koffi, Zie Cheick Traoré and Mohamed Kouyate

    BMC Cancer 2017 17:115

    Published on: 7 February 2017

  9. Study protocol

    Colorectal cancer surveillance in Hodgkin lymphoma survivors at increased risk of therapy-related colorectal cancer: study design

    Second primary malignancies are a major cause of excess morbidity and mortality in cancer survivors. Hodgkin lymphoma survivors who were treated with infradiaphragmatic radiotherapy and/or high-dose procarbazi...

    Lisanne S. Rigter, Manon C. W. Spaander, Leon M. Moons, Tanya M. Bisseling, Berthe M. P. Aleman, Jan Paul de Boer, Pieternella J. Lugtenburg, Cecile P. M. Janus, Eefke J. Petersen, Judith M. Roesink, John M. M. Raemaekers, Richard W. M. van der Maazen, Annemieke Cats, Eveline M. A. Bleiker, Petur Snaebjornsson, Beatriz Carvalho…

    BMC Cancer 2017 17:112

    Published on: 7 February 2017

  10. Research article

    Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer

    Protease activated receptor (PAR)-1 expression is increased in a variety of tumor cells. In preclinical models, tumor cell PAR-1 appeared to be involved in the regulation of lung tumor growth and metastasis; h...

    Cong Lin, Christof J. Majoor, Joris J. T. H. Roelofs, Martijn D. de Kruif, Hugo M. Horlings, Keren Borensztajn and C. Arnold Spek

    BMC Cancer 2017 17:113

    Published on: 7 February 2017

  11. Correspondence

    Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial

    The “TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia” (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clin...

    M. M. Koeneman, A. J. Kruse, L. F. S. Kooreman, A. zur Hausen, A. H. N. Hopman, S. J. S. Sep, T. Van Gorp, B. F. M. Slangen, H. J. van Beekhuizen, A. J. M. van de Sande, C. G. Gerestein, H. W. Nijman and R. F. P. M. Kruitwagen

    BMC Cancer 2017 17:110

    Published on: 7 February 2017

  12. Research article

    Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts

    Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers.

    Lina Leiss, Ercan Mutlu, Anne Øyan, Tao Yan, Oleg Tsinkalovsky, Linda Sleire, Kjell Petersen, Mohummad Aminur Rahman, Mireille Johannessen, Sidhartha S. Mitra, Hege K. Jacobsen, Krishna M. Talasila, Hrvoje Miletic, Inge Jonassen, Xingang Li, Nicolaas H. Brons…

    BMC Cancer 2017 17:108

    Published on: 7 February 2017

  13. Research article

    microRNA-29c inhibits cell proliferation by targeting NASP in human gastric cancer

    Gastric cancer is one of the most common malignancies worldwide. Recent studies have shown that microRNAs play crucial roles in regulating cellular proliferation process in gastric cancer. MicroRNA-29c (miR-29...

    Beiqin Yu, Xuehua Chen, Jianfang Li, Qinlong Gu, Zhenggang Zhu, Chen Li, Liping Su and Bingya Liu

    BMC Cancer 2017 17:109

    Published on: 7 February 2017

  14. Study protocol

    Molecular stool testing as an alternative for surveillance colonoscopy: a cross-sectional cohort study

    As in many other European countries, a nationwide screening program for colorectal cancer (CRC) has recently been introduced in the Netherlands. As a side effect, such a screening program will inherently yield...

    Meta C. J. van Lanschot, Beatriz Carvalho, Veerle M. H. Coupé, Manon van Engeland, Evelien Dekker and Gerrit A. Meijer

    BMC Cancer 2017 17:116

    Published on: 7 February 2017

  15. Research article

    Body mass index modifies the relationship between γ-H2AX, a DNA damage biomarker, and pathological complete response in triple-negative breast cancer

    Body mass index (BMI) is largely investigated as a prognostic and predictive factor in triple-negative breast cancer (TNBC). Overweight and obesity are linked to a variety of pathways regulating tumor-promotin...

    Maddalena Barba, Patrizia Vici, Laura Pizzuti, Luigi Di Lauro, Domenico Sergi, Anna Di Benedetto, Cristiana Ercolani, Francesca Sperati, Irene Terrenato, Claudio Botti, Lucia Mentuccia, Laura Iezzi, Teresa Gamucci, Clara Natoli, Ilio Vitale, Marcella Mottolese…

    BMC Cancer 2017 17:101

    Published on: 6 February 2017

  16. Research article

    Stromal alterations in ovarian cancers via wavelength dependent Second Harmonic Generation microscopy and optical scattering

    Ovarian cancer remains the most deadly gynecological cancer with a poor aggregate survival rate; however, the specific rates are highly dependent on the stage of the disease upon diagnosis. Current screening a...

    Karissa B. Tilbury, Kirby R. Campbell, Kevin W. Eliceiri, Sana M. Salih, Manish Patankar and Paul J. Campagnola

    BMC Cancer 2017 17:102

    Published on: 6 February 2017

  17. Research article

    Improving adherence to colorectal cancer surveillance guidelines: results of a randomised controlled trial

    Colorectal cancer (CRC) survivors are at increased risk of developing the disease again. Surveillance guidelines are aimed at maximising the early detection of recurring or new cancers and pre-cancerous polyps...

    Mariko Carey, Robert Sanson-Fisher, Finlay Macrae, Emilie Cameron, David Hill, Catherine D’Este and Christopher Doran

    BMC Cancer 2017 17:106

    Published on: 6 February 2017

  18. Study protocol

    Optitrain: a randomised controlled exercise trial for women with breast cancer undergoing chemotherapy

    Women with breast cancer undergoing chemotherapy suffer from a range of detrimental disease and treatment related side-effects. Exercise has shown to be able to counter some of these side-effects and improve p...

    Y. Wengström, K. A. Bolam, S. Mijwel, C. J. Sundberg, M. Backman, M. Browall, J. Norrbom and H. Rundqvist

    BMC Cancer 2017 17:100

    Published on: 6 February 2017

  19. Research article

    CLASP2 is involved in the EMT and early progression after transurethral resection of the bladder tumor

    Cytoplasmic linker-associated protein 2 (CLASP2) belongs to a family of microtubule plus-end tracking proteins that localizes to the distal ends of microtubules and regulate microtubule dynamics. We speculated...

    Bisong Zhu, Lin Qi, Sulai Liu, Wentao Liu, Zhenyu Ou, Minfeng Chen, Longfei Liu, Xiongbing Zu, Jun Wang and Yuan Li

    BMC Cancer 2017 17:105

    Published on: 6 February 2017

  20. Research article

    Mechanism of action of trabectedin in desmoplastic small round cell tumor cells

    Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive disease, that can be described as a member of the family of small round blue cell tumors. The molecular diagnostic marker is the t(11...

    S. Uboldi, I. Craparotta, G. Colella, E. Ronchetti, L. Beltrame, S. Vicario, S. Marchini, N. Panini, G. Dagrada, F. Bozzi, S. Pilotti, C. M. Galmarini, M. D’Incalci and R. Gatta

    BMC Cancer 2017 17:107

    Published on: 6 February 2017

  21. Research article

    Microparticles shed from multidrug resistant breast cancer cells provide a parallel survival pathway through immune evasion

    Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune response against foreign infiltrates....

    Ritu Jaiswal, Michael S. Johnson, Deep Pokharel, S. Rajeev Krishnan and Mary Bebawy

    BMC Cancer 2017 17:104

    Published on: 6 February 2017

  22. Study protocol

    Implementing exercise in cancer care: study protocol to evaluate a community-based exercise program for people with cancer

    Clinical research has established the efficacy of exercise in reducing treatment-related side-effects and increasing wellbeing in people with cancer. Major oncology organisations have identified the importance...

    Prue Cormie, Stephanie Lamb, Robert U. Newton, Lani Valentine, Sandy McKiernan, Nigel Spry, David Joseph, Dennis R. Taaffe, Christopher M. Doran and Daniel A. Galvão

    BMC Cancer 2017 17:103

    Published on: 6 February 2017

  23. Research article

    Curcumin decreases malignant characteristics of glioblastoma stem cells via induction of reactive oxygen species

    Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12–14 mo...

    Zachary C. Gersey, Gregor A. Rodriguez, Eric Barbarite, Anthony Sanchez, Winston M. Walters, Kelechi C. Ohaeto, Ricardo J. Komotar and Regina M. Graham

    BMC Cancer 2017 17:99

    Published on: 4 February 2017

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