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  1. Research article

    Characterization of MicroRNA-200 pathway in ovarian cancer and serous intraepithelial carcinoma of fallopian tube

    Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst form...

    Junzheng Yang, Yilan Zhou, Shu-Kay Ng, Kuan-Chun Huang, Xiaoyan Ni, Pui-Wah Choi, Kathleen Hasselblatt, Michael G. Muto, William R. Welch, Ross S. Berkowitz and Shu-Wing Ng

    BMC Cancer 2017 17:422

    Published on: 17 June 2017

  2. Research article

    What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group – EWING1

    Relapse in localized Ewing sarcoma patients has been a matter of concern regarding poor prognosis. Therefore, we investigated the impact of local control modality (surgery, surgery plus radiotherapy, and radio...

    Ricardo G. Becker, Lauro J. Gregianin, Carlos R. Galia, Reynaldo Jesus-Garcia Filho, Eduardo A. Toller, Gerardo Badell, Suely A. Nakagawa, Alexandre David, André M. Baptista, Eduardo S. Yonamime, Osvaldo A. Serafini, Valter Penna, Julie Francine C. Santos and Algemir L. Brunetto

    BMC Cancer 2017 17:420

    Published on: 15 June 2017

  3. Study protocol

    Effect of transcutaneous electrical stimulation treatment on lower urinary tract symptoms after class III radical hysterectomy in cervical cancer patients: study protocol for a multicentre, randomized controlled trial

    Class III radical hysterectomy (RH III)_plus pelvic lymphadenectomy is the standard surgery for early stage cervical cancer (CC) patients, the 5 year survival rate is about 90%, but pelvic floor disorders espe...

    Xiu-Li Sun, Hai-Bo Wang, Zhi-Qi Wang, Ting-ting Cao, Xin Yang, Jing-Song Han, Yang-feng Wu, Kathleen H. Reilly and Jian-Liu Wang

    BMC Cancer 2017 17:416

    Published on: 15 June 2017

  4. Research article

    Patterns of venous thromboembolism risk in patients with localized colorectal cancer undergoing adjuvant chemotherapy or active surveillance: an observational cohort study

    Venous thromoboembolism (VTE) is a frequent and burdensome complication of metastatic colorectal cancer (CRC). However, the epidemiology of VTE in patients with localized CRC after surgery in curative intent i...

    Jakob Michael Riedl, Florian Posch, Angelika Bezan, Joanna Szkandera, Maria Anna Smolle, Thomas Winder, Christopher H. Rossmann, Renate Schaberl-Moser, Martin Pichler, Michael Stotz, Herbert Stöger and Armin Gerger

    BMC Cancer 2017 17:415

    Published on: 15 June 2017

  5. Research article

    Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters

    CD40 signalling can synergise with chemotherapy in preclinical cancer models, and early clinical studies are promising. We set out to define the immunological changes associated with this therapeutic combinati...

    Alison M. McDonnell, Alistair Cook, Bruce W. S. Robinson, Richard A. Lake and Anna K. Nowak

    BMC Cancer 2017 17:417

    Published on: 15 June 2017

  6. Research article

    Prognostic impact of blood and urinary angiogenic factor levels at diagnosis and during treatment in patients with osteosarcoma: a prospective study

    Angiogenesis is essential for the progression and metastatic spread of solid tumours. Expression of vascular endothelial growth factor (VEGF) has been linked to poor survival among osteosarcoma patients but th...

    Marie-Dominique Tabone, Laurence Brugières, Sophie Piperno-Neumann, Marie-Ange Selva, Perrine Marec-Bérard, Hélène Pacquement, Cyril Lervat, Nadège Corradini, Jean-Claude Gentet, Rémy Couderc, Aurélie Chevance, Céline Mahier-Ait Oukhatar, Natacha Entz-Werle, Jean-Yves Blay and Marie-Cecile Le Deley

    BMC Cancer 2017 17:419

    Published on: 15 June 2017

  7. Research article

    Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors

    A high rate of glycolysis leading to elevated lactate content has been linked to poor clinical outcomes in patients with head and neck and cervical cancer treated with radiotherapy. Although the biological exp...

    Eric Leung, Rob A. Cairns, Naz Chaudary, Ravi N. Vellanki, Tuula Kalliomaki, Eduardo H. Moriyama, Hilda Mujcic, Brian C. Wilson, Bradly G. Wouters, Richard Hill and Michael Milosevic

    BMC Cancer 2017 17:418

    Published on: 15 June 2017

  8. Research article

    Reduced RCE1 expression predicts poor prognosis of colorectal carcinoma

    As an end-proteolytic enzyme that cleaves the last three residues of proteins with a terminal CAAX, Ras-converting enzyme 1 (RCE1) has an essential role in multiple signaling pathways and take part in the proc...

    Boyun Shi, Xinke Zhou, Lu He, Min Liang, Yuanwei Luo and Peng Jiang

    BMC Cancer 2017 17:414

    Published on: 14 June 2017

  9. Study protocol

    Internet-based perioperative exercise program in patients with Barrett’s carcinoma scheduled for esophagectomy [iPEP - study] a prospective randomized-controlled trial

    Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. T...

    Daniel Pfirrmann, Suzan Tug, Oana Brosteanu, Matthias Mehdorn, Martin Busse, Peter P. Grimminger, Florian Lordick, Torben Glatz, Jens Hoeppner, Hauke Lang, Perikles Simon and Ines Gockel

    BMC Cancer 2017 17:413

    Published on: 14 June 2017

  10. Research article

    Prognostic factors and outcome of Liposarcoma patients: a retrospective evaluation over 15 years

    Soft tissue sarcomas are rare entities with over 50 histological subtypes. Liposarcoma (LS) is the most common neoplasm in this group; it is a complex neoplasm that is divided into different histological subty...

    Carolin Knebel, Ulrich Lenze, Florian Pohlig, Florian Lenze, Norbert Harrasser, Christian Suren, Jonathan Breitenbach, Hans Rechl, Rüdiger von Eisenhart-Rothe and Heinrich M. L. Mühlhofer

    BMC Cancer 2017 17:410

    Published on: 12 June 2017

  11. Research article

    Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts

    Studies comparing the effect of antiangiogenic agents targeting different angiogenic pathways are sparse. The purpose of this study was to compare the effect of properdistatin and sunitinib treatment in a prec...

    Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen and Einar K. Rofstad

    BMC Cancer 2017 17:411

    Published on: 12 June 2017

  12. Research article

    Pooled safety analyses of ALK-TKI inhibitor in ALK-positive NSCLC

    The anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKIs) have been administered to patients with ALK-positive non-small cell lung cancer for a long period of time and show a promising response. How...

    Qian Zhu, Hao Hu, De-Sheng Weng, Xiao-Fei Zhang, Chang-Long Chen, Zi-Qi Zhou, Yan Tang and Jian-Chuan Xia

    BMC Cancer 2017 17:412

    Published on: 12 June 2017

  13. Research article

    Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma

    Granulin-epithelin precursor (GEP) is a secretory growth factor, which has been demonstrated to control cancer growth, invasion, drug resistance and immune escape. Our previous studies and others also demonstr...

    Chi Wai Yip, Ching Yan Lam, Terence C. W. Poon, Tan To Cheung, Phyllis F. Y. Cheung, Sze Wai Fung, Xiao Qi Wang, Idy C.Y. Leung, Linda W. C. Ng, Chung Mau Lo, George S. W. Tsao and Siu Tim Cheung

    BMC Cancer 2017 17:409

    Published on: 10 June 2017

  14. Study protocol

    TRIBE-2: a phase III, randomized, open-label, strategy trial in unresectable metastatic colorectal cancer patients by the GONO group

    Chemotherapy plus bevacizumab is a standard first-line treatment for unresectable metastatic colorectal cancer patients. Different chemotherapy backbones may be chosen, including one to three drugs, based on p...

    Chiara Cremolini, Federica Marmorino, Fotios Loupakis, Gianluca Masi, Carlotta Antoniotti, Lisa Salvatore, Marta Schirripa, Luca Boni, Vittorina Zagonel, Sara Lonardi, Giuseppe Aprile, Emiliano Tamburini, Vincenzo Ricci, Monica Ronzoni, Filippo Pietrantonio, Chiara Valsuani…

    BMC Cancer 2017 17:408

    Published on: 9 June 2017

  15. Research article

    Phase I study of oral ridaforolimus in combination with paclitaxel and carboplatin in patients with solid tumor cancers

    Ridaforolimus is a mammalian target of rapamycin inhibitor that has activity in solid tumors. Paclitaxel and carboplatin have broad antineoplastic activity in many cancers. This phase I trial was conducted to ...

    Hye Sook Chon, Sokbom Kang, Jae K. Lee, Sachin M. Apte, Mian M. Shahzad, Irene Williams-Elson and Robert M. Wenham

    BMC Cancer 2017 17:407

    Published on: 8 June 2017

  16. Research article

    Is detection of intraperitoneal exfoliated tumor cells after surgical resection of rectal cancer a prognostic factor of survival?

    The prognostic significance of free cancer cells detected in peritoneal fluid at the time of rectal surgery remains unclear. A substantial number of patients will develop metastatic disease even with successfu...

    Christian Arstad, Paulo Refinetti, Annette Torgunrud Kristensen, Karl-Erik Giercksky and Per Olaf Ekstrøm

    BMC Cancer 2017 17:406

    Published on: 7 June 2017

  17. Research article

    Lipodox® (generic doxorubicin hydrochloride liposome injection): in vivo efficacy and bioequivalence versus Caelyx® (doxorubicin hydrochloride liposome injection) in human mammary carcinoma (MX-1) xenograft and syngeneic fibrosarcoma (WEHI 164) mouse models

    Doxorubicin (DXR) hydrochloride (HCl) liposome injection is an important part of the treatment armamentarium for a number of cancers. With growing needs for affordable and effective anticancer treatments, the ...

    Vinod Burade, Subhas Bhowmick, Kuntal Maiti, Rishit Zalawadia, Harry Ruan and Rajamannar Thennati

    BMC Cancer 2017 17:405

    Published on: 6 June 2017

  18. Research article

    The peripheral monocyte count is associated with the density of tumor-associated macrophages in the tumor microenvironment of colorectal cancer: a retrospective study

    Inflammation is widely recognized to play an important role in cancer progression, and the peripheral monocyte count has been reported to correlate with the prognosis in patients with colorectal cancer. This i...

    Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shigetomi Nakao, Shinji Matsutani, Kosei Hirakawa and Masaichi Ohira

    BMC Cancer 2017 17:404

    Published on: 5 June 2017

  19. Research article

    Most children with cancer are not enrolled on a clinical trial in Canada: a population-based study

    Primary objective was to describe the proportion of children newly diagnosed with cancer enrolled on a therapeutic clinical trial. Secondary objectives were to describe reasons for non-enrollment and factors a...

    Jason D. Pole, Randy Barber, Rose-Émilie Bergeron, Anne Sophie Carret, David Dix, Ketan Kulkarni, Emilie Martineau, Alicia Randall, David Stammers, Caron Strahlendorf, Douglas R. Strother, Tony H. Truong and Lillian Sung

    BMC Cancer 2017 17:402

    Published on: 5 June 2017

  20. Study protocol

    ICORG 10-14: NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study (Neo-AEGIS)

    Neoadjuvant therapy is increasingly the standard of care in the management of locally advanced adenocarcinoma of the oesophagus and junction (AEG). In randomised controlled trials (RCTs), the MAGIC regimen of ...

    JV Reynolds, SR Preston, B O’Neill, L Baeksgaard, SM Griffin, C Mariette, S Cuffe, M Cunningham, T Crosby, I Parker, K Hofland, G Hanna, LB Svendsen, CL Donohoe, C Muldoon, D O’Toole…

    BMC Cancer 2017 17:401

    Published on: 3 June 2017

  21. Study protocol

    Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy -- design of the DAHANCA 31 randomized trial

    Head and neck cancer patients undergoing concomitant chemoradiotherapy (CCRT) frequently experience loss of muscle mass and reduced functional performance. Positive effects of exercise training are reported fo...

    Camilla K. Lonkvist, Simon Lønbro, Anders Vinther, Bo Zerahn, Eva Rosenbom, Hanne Primdahl, Pernille Hojman and Julie Gehl

    BMC Cancer 2017 17:400

    Published on: 3 June 2017

  22. Research article

    A nationwide multi-institutional retrospective study to identify prognostic factors and develop a graded prognostic assessment system for patients with brain metastases from uterine corpus and cervical cancer

    The prevalence of brain metastases (BM) from uterine cancer has recently increased because of the improvement of overall survival (OS) of patients with uterine cancer due to its early detection and improved lo...

    Nakamasa Hayashi, Hideaki Takahashi, Yuzo Hasegawa, Fumi Higuchi, Masamichi Takahashi, Keishi Makino, Masatoshi Takagaki, Jiro Akimoto, Takeshi Okuda, Yoshiko Okita, Koichi Mitsuya, Yasuyuki Hirashima, Yoshitaka Narita and Yoko Nakasu

    BMC Cancer 2017 17:397

    Published on: 2 June 2017

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