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  1. Research article

    Appraising the holistic value of Lenvatinib for radio-iodine refractory differentiated thyroid cancer: A multi-country study applying pragmatic MCDA

    The objective of the study was to reveal through pragmatic MCDA (EVIDEM) the contribution of a broad range of criteria to the value of the orphan drug lenvatinib for radioiodine refractory differentiated thyro...

    Monika Wagner, Hanane Khoury, Liga Bennetts, Patrizia Berto, Jenifer Ehreth, Xavier Badia and Mireille Goetghebeur

    BMC Cancer 2017 17:272

    Published on: 17 April 2017

  2. Research article

    Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC)

    Patients with small-cell lung cancer (SCLC) patients demonstrate varied survival outcomes. Previous studies have reported that lipoproteins are associated with prognosis in various cancers; however, the role o...

    Ting Zhou, Jianhua Zhan, Wenfeng Fang, Yuanyuan Zhao, Yunpeng Yang, Xue Hou, Zhonghan Zhang, Xiaobo He, Yaxiong Zhang, Yan Huang and Li Zhang

    BMC Cancer 2017 17:269

    Published on: 14 April 2017

  3. Research article

    Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer

    OPCML belongs to the IgLON family of Ig domain–containing GPI-anchored cell adhesion molecules and was recently found to be involved in carcinogenesis, while its role in gastric cancer remains unclear.

    Xiangbin Xing, Weibin Cai, Sanmei Ma, Yongfei Wang, Huijuan Shi, Ming Li, Jinxia Jiao, Yang Yang, Longshan Liu, Xiangliang Zhang and Minhu Chen

    BMC Cancer 2017 17:268

    Published on: 14 April 2017

  4. Research article

    Overview of cancer incidence and mortality among people living with HIV/AIDS in British Columbia, Canada: Implications for HAART use and NADM development

    The objective of this study is to evaluate the incidence of non-AIDS defining malignancies (NADMs) among people living with HIV/AIDS (PLWHA) in British Columbia, focusing on clinical correlates, highly active ...

    Connie G. Chiu, Danielle Smith, Kate A. Salters, Wendy Zhang, Steve Kanters, David Milan, Julio S.G. Montaner, Andy Coldman, Robert S. Hogg and Sam M. Wiseman

    BMC Cancer 2017 17:270

    Published on: 14 April 2017

  5. Case report

    Alpha–fetoprotein elevation in NUT midline carcinoma: a case report

    Nuclear protein in testis (NUT) midline carcinoma is a rarely diagnosed and potentially under-recognized type of squamous carcinoma that is considered one of the most aggressive human solid tumors. Alpha-fetop...

    Lorenzo D’Ambrosio, Erica Palesandro, Marina Moretti, Giuseppe Pelosi, Alessandra Fabbri, Fabrizio Carnevale Schianca, Massimo Aglietta and Giovanni Grignani

    BMC Cancer 2017 17:266

    Published on: 13 April 2017

  6. Research article

    A prediction model for lymph node metastases using pathologic features in patients intraoperatively diagnosed as stage I non-small cell lung cancer

    There is little information on which pattern should be chosen to perform lymph node dissection for stage I non-small-cell lung cancer. This study aimed to develop a model for predicting lymph node metastasis u...

    Fei Zhao, Yue Zhou, Peng-Fei Ge, Chen-Jun Huang, Yue Yu, Jun Li, Yun-Gang Sun, Yang-Chun Meng, Jian-Xia Xu, Ting Jiang, Zhi-Xuan Zhang, Jin-Peng Sun and Wei Wang

    BMC Cancer 2017 17:267

    Published on: 13 April 2017

  7. Research article

    Adjuvant treatment recommendations for patients with ER-positive/HER2-negative early breast cancer by Swiss tumor boards using the 21-gene recurrence score (SAKK 26/10)

    To evaluate the effect of Recurrence Score® results (RS; Oncotype DX® multigene assay ODX) on treatment recommendations by Swiss multidisciplinary tumor boards (TB).

    Bernhard C. Pestalozzi, Christoph Tausch, Konstantin J. Dedes, Christoph Rochlitz, Stefan Zimmermann, Roger von Moos, Ralph Winterhalder, Thomas Ruhstaller, Andreas Mueller, Katharina Buser, Markus Borner, Urban Novak, Catrina Uhlmann Nussbaum, Bettina Seifert, Martin Bigler, Vincent Bize…

    BMC Cancer 2017 17:265

    Published on: 13 April 2017

  8. Research article

    Effect of individualized communication skills training on physicians’ discussion of clinical trials in oncology: results from a randomized controlled trial

    Discussing randomized clinical trials (RCTs) with cancer patients is one of the most challenging communication tasks a physician faces. Only two prior Communication Skills Trainings (CSTs) focused on RCTs in o...

    Alexander Wuensch, Tanja Goelz, Gabriele Ihorst, Darcey D. Terris, Hartmut Bertz, Juergen Bengel, Michael Wirsching and Kurt Fritzsche

    BMC Cancer 2017 17:264

    Published on: 13 April 2017

  9. Research article

    MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study

    Mucin 1 (MUC1) contributes to the growth and metastasis of various cancers, including lung cancer, and MUC1 gene length polymorphisms are associated with susceptibility to lung cancer and its prognosis. In contra...

    Yasushi Horimasu, Nobuhisa Ishikawa, Sonosuke Tanaka, Chihiro Hirano, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori and Nobuoki Kohno

    BMC Cancer 2017 17:263

    Published on: 12 April 2017

  10. Research article

    Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression

    H3K27me3 histone marks shape the inhibition of gene transcription. In prostate cancer, the deregulation of H3K27me3 marks might play a role in prostate tumor progression.

    Marjolaine Ngollo, Andre Lebert, Marine Daures, Gaelle Judes, Khaldoun Rifai, Lucas Dubois, Jean-Louis Kemeny, Frederique Penault-Llorca, Yves-Jean Bignon, Laurent Guy and Dominique Bernard-Gallon

    BMC Cancer 2017 17:261

    Published on: 12 April 2017

  11. Debate

    Infections and cancer: the “fifty shades of immunity” hypothesis

    Since the beginning of the twentieth century, infection has emerged as a fundamental aspect of cancer causation with a growing number of pathogens recognized as oncogenic. Meanwhile, oncolytic viruses have als...

    Camille Jacqueline, Aurélie Tasiemski, Gabriele Sorci, Beata Ujvari, Fatima Maachi, Dorothée Missé, François Renaud, Paul Ewald, Frédéric Thomas and Benjamin Roche

    BMC Cancer 2017 17:257

    Published on: 12 April 2017

  12. Research article

    Systemic therapy in younger and elderly patients with advanced biliary cancer: sub-analysis of ABC-02 and twelve other prospective trials

    Outcomes in younger (<40 years) and elderly (≥70 years) patients with advanced biliary cancer (ABC) receiving palliative chemotherapy are unclear. This study assessed outcomes in those receiving monotherapy or...

    Mairéad Geraldine McNamara, John Bridgewater, Andre Lopes, Harpreet Wasan, David Malka, Lars Henrik Jensen, Takuji Okusaka, Jennifer J. Knox, Dorothea Wagner, David Cunningham, Jenny Shannon, David Goldstein, Markus Moehler, Tanios Bekaii-Saab and Juan W. Valle

    BMC Cancer 2017 17:262

    Published on: 12 April 2017

  13. Research article

    Hypermethylation of CDKN2A exon 2 in tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients

    Breast carcinogenesis is a multistep process involving genetic and epigenetic changes. Tumor tissues are frequently characterized by gene-specific hypermethylation and global DNA hypomethylation. Aberrant DNA ...

    Melanie Spitzwieser, Elisabeth Entfellner, Bettina Werner, Walter Pulverer, Georg Pfeiler, Stefan Hacker and Margit Cichna-Markl

    BMC Cancer 2017 17:260

    Published on: 12 April 2017

  14. Study protocol

    Gamma probe and ultrasound guided fine needle aspiration cytology of the sentinel node (GULF) trial - overview of the literature, pilot and study protocol

    Sentinel node (SN) biopsy (SNB) detects clinically occult metastases of breast cancer and melanoma in 20–30%. Wound infections, seroma and lymph edema occur in up to 10%. Targeted ultrasound (US) of the SN, (w...

    Charlotte M.C. Oude Ophuis, Lisa (Linetta) B. Koppert, Cécile de Monyé, Carolien H.M. van Deurzen, Senada Koljenović, Alexander C.J. van Akkooi, Cornelis (Kees) Verhoef and Dirk J. Grünhagen

    BMC Cancer 2017 17:258

    Published on: 12 April 2017

  15. Study protocol

    A multicentre randomised controlled trial to evaluate the efficacy, morbidity and functional outcome of endoscopic transanal proctectomy versus laparoscopic proctectomy for low-lying rectal cancer (ETAP-GRECCAR 11 TRIAL): rationale and design

    Total mesorectal excision is the standard surgical treatment for mid- and low-rectal cancer. Laparoscopy represents a clear leap forward in the management of rectal cancer patients, offering significant improv...

    Bernard Lelong, Cécile de Chaisemartin, Helene Meillat, Sandra Cournier, Jean Marie Boher, Dominique Genre, Mehdi Karoui, Jean Jacques Tuech and Jean Robert Delpero

    BMC Cancer 2017 17:253

    Published on: 11 April 2017

  16. Research article

    Cost-effectiveness of response evaluation after chemoradiation in patients with advanced oropharyngeal cancer using 18F–FDG-PET-CT and/or diffusion-weighted MRI

    Considerable variation exists in diagnostic tests used for local response evaluation after chemoradiation in patients with advanced oropharyngeal cancer. The yield of invasive examination under general anesthe...

    Marjolein JE Greuter, Charlotte S Schouten, Jonas A Castelijns, Pim de Graaf, Emile FI Comans, Otto S Hoekstra, Remco de Bree and Veerle MH Coupé

    BMC Cancer 2017 17:256

    Published on: 11 April 2017

  17. Research article

    Sidedness is prognostic in locoregional colon cancer: an analysis of 9509 Australian patients

    Right sided colon cancer (RsCC) is proposed to be a distinct disease entity to left sided colon cancer (LsCC). We seek to confirm primary tumour location as an independent prognostic factor in locoregional col...

    Daniel Brungs, Morteza Aghmesheh, Paul de Souza, Weng Ng, Wei Chua, Martin Carolan, Philip Clingan, Emma Healey, June Rose, Tameika Tubaro and Marie Ranson

    BMC Cancer 2017 17:251

    Published on: 8 April 2017

  18. Case report

    Myoepithelial carcinoma with RB1 mutation: remarkable chemosensitivity to carcinoma of unknown origin therapy

    Myoepithelial carcinoma of soft tissue is a rare, malignant neoplasm that is morphologically and immunophenotypically similar to its counterpart in salivary gland. It demonstrates myoepithelial differentiation...

    Timothy M. Hoggard, Evita Henderson-Jackson, Marilyn M. Bui, Jamie Caracciolo, Jamie K. Teer, Sean Yoder, Odion Binitie, Ricardo J. Gonzalez, Andrew S. Brohl and Damon R. Reed

    BMC Cancer 2017 17:250

    Published on: 8 April 2017

  19. Research article

    Inhibition of Six1 affects tumour invasion and the expression of cancer stem cell markers in pancreatic cancer

    Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression and metastasis. Assessment of transcription factors involved in these two mechanisms can help to identify...

    Tristan Lerbs, Savita Bisht, Sebastian Schölch, Mathieu Pecqueux, Glen Kristiansen, Martin Schneider, Bianca T. Hofmann, Thilo Welsch, Christoph Reissfelder, Nuh N. Rahbari, Johannes Fritzmann, Peter Brossart, Jürgen Weitz, Georg Feldmann and Christoph Kahlert

    BMC Cancer 2017 17:249

    Published on: 7 April 2017

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