Translational oncology

This section aims to consider publications which bridge laboratory basic science and applied clinical research. The section will publish studies of diagnostic and prognostic markers which may ultimately be applicable in a clinical setting with a special focus on molecular and experimental pathology. Submissions need to be REMARK compliant as established in NCI-EORTC's "Reporting Recommendations for Tumor Marker Prognostic Studies " (J Clin Oncol 23:9067, 2005) and should report biomarkers that have a clear biologic relevance to a particular tumor type.

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  1. Research article

    Prognostic and predictive factors in patients with metastatic or recurrent cervical cancer treated with platinum-based chemotherapy.

    Recognizing resistance or susceptibility to the current standard cisplatin and paclitaxel treatment could improve therapeutic outcomes of metastatic or recurrent cervical cancer.

    Sofia Karageorgopoulou, Ioannis D. Kostakis, Maria Gazouli, Sonia Markaki, Marios Papadimitriou, Evangelos Bournakis, Meletios-Athanassios Dimopoulos and Christos A Papadimitriou

    BMC Cancer 2017 17:451

    Published on: 28 June 2017

  2. Research article

    The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas

    The Hippo pathway plays a vital role in liver regeneration and development by determining cellular lineage and regulating cell proliferation and apoptosis. In this study, we aimed to assess the role of the Hip...

    KyuHo Lee, Kyoung-Bun Lee, Hae Yoen Jung, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh and Ja-June Jang

    BMC Cancer 2017 17:441

    Published on: 23 June 2017

  3. Research article

    Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis

    To evaluate a new UGT1A and DPYD polymorphism panel to better predict irinotecan-induced toxicity and the clinical response in Chinese patients with metastatic colorectal cancer (mCRC).

    Dan Liu, Jian Li, Jing Gao, Yanyan Li, Rui Yang and Lin Shen

    BMC Cancer 2017 17:437

    Published on: 20 June 2017

  4. Research article

    Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

    Retinoblastoma (Rb) is the most common primary intraocular tumor in children. Local treatment of the intraocular disease is usually effective if diagnosed early; however advanced Rb can metastasize through rou...

    Anderson H. Webb, Bradley T. Gao, Zachary K. Goldsmith, Andrew S. Irvine, Nabil Saleh, Ryan P. Lee, Justin B. Lendermon, Rajini Bheemreddy, Qiuhua Zhang, Rachel C. Brennan, Dianna Johnson, Jena J. Steinle, Matthew W. Wilson and Vanessa M. Morales-Tirado

    BMC Cancer 2017 17:434

    Published on: 20 June 2017

  5. Research article

    Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters

    CD40 signalling can synergise with chemotherapy in preclinical cancer models, and early clinical studies are promising. We set out to define the immunological changes associated with this therapeutic combinati...

    Alison M. McDonnell, Alistair Cook, Bruce W. S. Robinson, Richard A. Lake and Anna K. Nowak

    BMC Cancer 2017 17:417

    Published on: 15 June 2017

  6. Research article

    Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors

    A high rate of glycolysis leading to elevated lactate content has been linked to poor clinical outcomes in patients with head and neck and cervical cancer treated with radiotherapy. Although the biological exp...

    Eric Leung, Rob A. Cairns, Naz Chaudary, Ravi N. Vellanki, Tuula Kalliomaki, Eduardo H. Moriyama, Hilda Mujcic, Brian C. Wilson, Bradly G. Wouters, Richard Hill and Michael Milosevic

    BMC Cancer 2017 17:418

    Published on: 15 June 2017

  7. Research article

    Reduced RCE1 expression predicts poor prognosis of colorectal carcinoma

    As an end-proteolytic enzyme that cleaves the last three residues of proteins with a terminal CAAX, Ras-converting enzyme 1 (RCE1) has an essential role in multiple signaling pathways and take part in the proc...

    Boyun Shi, Xinke Zhou, Lu He, Min Liang, Yuanwei Luo and Peng Jiang

    BMC Cancer 2017 17:414

    Published on: 14 June 2017

  8. Case report

    Switch in KRAS mutational status during an unusual course of disease in a patient with advanced pancreatic adenocarcinoma: implications for translational research

    Despite the introduction of novel effective treatment regimens like gemcitabine plus nab-paclitaxel and FOLFIRINOX, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive epithelial tumors....

    Sibylle Baechmann, Steffen Ormanns, Michael Haas, Stephan Kruger, Anna Remold, Dominik Paul Modest, Thomas Kirchner, Andreas Jung, Jens Werner, Volker Heinemann and Stefan Boeck

    BMC Cancer 2017 17:374

    Published on: 26 May 2017

  9. Technical advance

    Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium

    Patients with tongue cancer frequently show loss of heterozygosity (LOH) of the von Hippel–Lindau (VHL) tumor suppressor gene. However, expression of VHL protein (pVHL) in tongue cancer has rarely been investigat...

    Hisashi Hasegawa, Yoshiaki Kusumi, Takeshi Asakawa, Miyoko Maeda, Toshinori Oinuma, Tohru Furusaka, Takeshi Oshima and Mariko Esumi

    BMC Cancer 2017 17:381

    Published on: 26 May 2017

  10. Research article

    Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma

    Glyoxalase 1 is a key enzyme in the detoxification of reactive metabolites such as methylglyoxal and induced Glyoxalase 1 expression has been demonstrated for several human malignancies. However, the regulatio...

    Nele Kreycy, Christiane Gotzian, Thomas Fleming, Christa Flechtenmacher, Niels Grabe, Peter Plinkert, Jochen Hess and Karim Zaoui

    BMC Cancer 2017 17:382

    Published on: 26 May 2017

  11. Research article

    Fluorescent CXCR4 targeting peptide as alternative for antibody staining in Ewing sarcoma

    Ewing sarcoma is an aggressive, highly metastatic primary bone and soft tissue tumor most frequently occurring in the bone of young adolescents. Patients, especially those diagnosed with a metastatic disease, ...

    Laurens G. L. Sand, Tessa Buckle, Fijs W. B. van Leeuwen, Willem E. Corver, Alwine B. Kruisselbrink, Aart G. Jochemsen, Pancras C. W. Hogendoorn and Károly Szuhai

    BMC Cancer 2017 17:383

    Published on: 26 May 2017

  12. Research article

    Insulin-like growth factor 1 receptor affects the survival of primary prostate cancer patients depending on TMPRSS2-ERG status

    Prostate cancer (PCa) is characterized by clinical and biological heterogeneity and has differential outcomes and mortality rates. Therefore, it is necessary to identify molecular alterations to define new the...

    Caterina Mancarella, Irene Casanova-Salas, Ana Calatrava, Maria García-Flores, Cecilia Garofalo, Andrea Grilli, José Rubio-Briones, Katia Scotlandi and José Antonio López-Guerrero

    BMC Cancer 2017 17:367

    Published on: 25 May 2017

  13. Research article

    Power of PgR expression as a prognostic factor for ER-positive/HER2-negative breast cancer patients at intermediate risk classified by the Ki67 labeling index

    The Ki67 labeling index (LI) is regarded as a significant prognostic marker in ER-positive/HER2-negative breast cancer patients. The expression of PgR has recently been identified as another prognostic marker....

    Sasagu Kurozumi, Hiroshi Matsumoto, Yuji Hayashi, Katsunori Tozuka, Kenichi Inoue, Jun Horiguchi, Izumi Takeyoshi, Tetsunari Oyama and Masafumi Kurosumi

    BMC Cancer 2017 17:354

    Published on: 22 May 2017

  14. Research article

    Venous thromboembolism in hospitalized patients receiving chemotherapy for malignancies at Japanese community hospital: prospective observational study

    Although Asian population was recognized to have a lower risk of venous thromboembolism (VTE), its increasing prevalence and incidence remain unclear in patients with malignancies. We attempted to predict VTE ...

    Hiromitsu Kitayama, Tomohiro Kondo, Junko Sugiyama, Kazutomo Kurimoto, Yasuhiro Nishino, Michiaki Hirayama and Yasushi Tsuji

    BMC Cancer 2017 17:351

    Published on: 19 May 2017

  15. Case report

    PD-L1 expressing circulating tumour cells in head and neck cancers

    Blockade of the PD-1/PD-L1 immune checkpoint pathway is emerging as a promising immunotherapeutic approach for the management and treatment of head and neck cancer patients who do not respond to 1st/2nd line t...

    Arutha Kulasinghe, Chris Perry, Liz Kenny, Majid E. Warkiani, Colleen Nelson and Chamindie Punyadeera

    BMC Cancer 2017 17:333

    Published on: 16 May 2017

  16. Research article

    The role of BRCA1-IRIS in the development and progression of triple negative breast cancers in Egypt: possible link to disease early lesion

    Breast cancer is the most globally diagnosed female cancer, with the triple negative breast cancer (TNBC) being the most aggressive subtype of the disease. In this study we aimed at comparing the effect of BRC...

    Danielle Bogan, Lucio Meile, Ahmed El Bastawisy, Hend F. Yousef, Abdel-Rahman N. Zekri, Abeer A. Bahnassy and Wael M. ElShamy

    BMC Cancer 2017 17:329

    Published on: 12 May 2017

  17. Research article

    Gamma-glutamyltransferase activity in exosomes as a potential marker for prostate cancer

    Exosomes or extracellular vesicles have the potential as a diagnostic marker for various diseases including cancer. In order to identify novel exosomal markers for prostate cancer (PC), we performed proteomic ...

    Kyojiro Kawakami, Yasunori Fujita, Yoko Matsuda, Tomio Arai, Kengo Horie, Koji Kameyama, Taku Kato, Koichi Masunaga, Yutaka Kasuya, Masashi Tanaka, Kosuke Mizutani, Takashi Deguchi and Masafumi Ito

    BMC Cancer 2017 17:316

    Published on: 5 May 2017

  18. Research article

    Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas

    Fibroblast growth factor receptors (FGFRs) are well-known proto-oncogenes in several human malignancies and are currently therapeutically targeted in clinical trials. Among glioma subtypes, activating FGFR1 al...

    Birgitta Lehtinen, Annina Raita, Juha Kesseli, Matti Annala, Kristiina Nordfors, Olli Yli-Harja, Wei Zhang, Tapio Visakorpi, Matti Nykter, Hannu Haapasalo and Kirsi J. Granberg

    BMC Cancer 2017 17:310

    Published on: 3 May 2017

  19. Study protocol

    Imatinib treatment of poor prognosis mesenchymal-type primary colon cancer: a proof-of-concept study in the preoperative window period (ImPACCT)

    The identification of four Consensus Molecular Subtypes (CMS1–4) of colorectal cancer forms a new paradigm for the design and evaluation of subtype-directed therapeutic strategies. The most aggressive subtype ...

    I. Ubink, H. J. Bloemendal, S. G. Elias, M. A. Brink, M. P. Schwartz, Y. C. W. Holierhoek, P. M. Verheijen, A. W. Boerman, R. H. J. Mathijssen, W. W. J. de Leng, R. A. de Weger, W. M. U. van Grevenstein, M. Koopman, M. P. Lolkema, O. Kranenburg and I. H. M. Borel Rinkes

    BMC Cancer 2017 17:282

    Published on: 19 April 2017

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