Medical and radiation oncology

Section edited by Dirk Vordermark

This section focuses on clinical research that impacts on the treatment of cancer using systemic chemotherapy, targeted therapy, and radiation.

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  1. Research article

    Prospective phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy

    We designed a single-arm, open-label phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy (#NCT02449538).

    Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Won Ki Kang and Ho Yeong Lim

    BMC Cancer 2017 17:211

    Published on: 23 March 2017

  2. Study protocol

    Uniform FDG-PET guided GRAdient Dose prEscription to reduce late Radiation Toxicity (UPGRADE-RT): study protocol for a randomized clinical trial with dose reduction to the elective neck in head and neck squamous cell carcinoma

    In definitive radiation therapy for head and neck cancer, clinically uninvolved cervical lymph nodes are irradiated with a so-called ‘elective dose’ in order to achieve control of clinically occult metastases....

    Sven van den Bosch, Tim Dijkema, Martina C. Kunze-Busch, Chris H. J. Terhaard, Cornelis P. J. Raaijmakers, Patricia A. H. Doornaert, Frank J. P. Hoebers, Marije R. Vergeer, Bas Kreike, Oda B. Wijers, Wim J. G. Oyen and Johannes H. A. M. Kaanders

    BMC Cancer 2017 17:208

    Published on: 21 March 2017

  3. Case report

    Objective response to mTOR inhibition in a metastatic collision tumor of the liver composed of melanoma and adenocarcinoma with TSC1 loss: a case report

    Collision tumors are uncommon but well described clinical entities composed of distinct tumor histologies occurring within the same anatomic site. Optimal management of patients with collision tumors remains h...

    Munveer S. Bhangoo, Jenny Y. Zhou, Siraj M. Ali, Russell Madison, Alexa B. Schrock and Carrie Costantini

    BMC Cancer 2017 17:197

    Published on: 16 March 2017

  4. Research article

    A multi-center phase II study and biomarker analysis of combined cetuximab and modified FOLFIRI as second-line treatment in patients with metastatic gastric cancer

    To evaluate the efficacy of cetuximab combined with modified FOLFIRI (mFOLFIRI) as a second-line treatment in metastatic gastric cancer patients and to identify potential biomarkers of clinical outcomes.

    Xin Liu, Weijian Guo, Wen Zhang, Jiliang Yin, Jun Zhang, Xiaodong Zhu, Tianshu Liu, Zhiyu Chen, Biyun Wang, Jianhua Chang, Fangfang Lv, Xiaonan Hong, Huijie Wang, Jialei Wang, Xinmin Zhao, Xianghua Wu…

    BMC Cancer 2017 17:188

    Published on: 14 March 2017

  5. Research article

    Patients with pathological stage N2 rectal cancer treated with early adjuvant chemotherapy have a lower treatment failure rate

    In this era of oxaliplatin-based adjuvant therapy, the optimal sequence in which chemoradiotherapy should be administered for pathological stage N2 rectal cancer is unknown. The aim of this study was to invest...

    Yan-Ru Feng, Jing Jin, Hua Ren, Xin Wang, Shu-Lian Wang, Wei-Hu Wang, Yong-Wen Song, Yue-Ping Liu, Yuan Tang, Ning Li, Xin-Fan Liu, Hui Fang, Zi-Hao Yu and Ye-Xiong Li

    BMC Cancer 2017 17:182

    Published on: 9 March 2017

  6. Study protocol

    Redefining radiotherapy for early-stage breast cancer with single dose ablative treatment: a study protocol

    A shift towards less burdening and more patient friendly treatments for breast cancer is currently ongoing. In low-risk patients with early-stage disease, accelerated partial breast irradiation (APBI) is an al...

    R. K. Charaghvandi, B. van Asselen, M. E. P. Philippens, H. M. Verkooijen, C. H. van Gils, P. J. van Diest, R. M. Pijnappel, M. G. G. Hobbelink, A. J. Witkamp, T. van Dalen, E. van der Wall, T. C. van Heijst, R. Koelemij, M. van Vulpen and H. J. G. D. van den Bongard

    BMC Cancer 2017 17:181

    Published on: 9 March 2017

  7. Study protocol

    Stereotactic prostate adaptive radiotherapy utilising kilovoltage intrafraction monitoring: the TROG 15.01 SPARK trial

    This paper describes the multi-institutional prospective phase II clinical trial, SPARK: Stereotactic Prostate Adaptive Radiotherapy utilizing Kilovoltage Intrafraction Monitoring (KIM). KIM is a real-time image ...

    Paul Keall, Doan Trang Nguyen, Ricky O’Brien, Jeremy Booth, Peter Greer, Per Poulsen, Val Gebski, Andrew Kneebone and Jarad Martin

    BMC Cancer 2017 17:180

    Published on: 8 March 2017

  8. Research article

    Access to principal treatment centres and survival rates for children and young people with cancer in Yorkshire, UK

    Principal Treatment Centres (PTC) were established to provide age-appropriate care as well as clinical expertise for children and young people with cancer. However, little is known about the effects of special...

    Lesley Fairley, Daniel P. Stark, Daniel Yeomanson, Sally E. Kinsey, Adam W. Glaser, Susan V. Picton, Linda Evans and Richard G. Feltbower

    BMC Cancer 2017 17:168

    Published on: 4 March 2017

  9. Case report

    Cardiac metastasis from colon cancer effectively treated with 5-fluorouracil, leucovorin, and oxaliplatin (modified FOLFOX6) plus panitumumab: a case report

    Cardiac metastasis from colorectal cancer is rare. There is little evidence supporting the effectiveness of chemotherapy, and standard therapy for metastatic cardiac tumors has not been established.

    Yoshiki Tsujii, Yoshito Hayashi, Akira Maekawa, Tetsuji Fujinaga, Kengo Nagai, Shunsuke Yoshii, Akihiko Sakatani, Satoshi Hiyama, Shinichiro Shinzaki, Hideki Iijima and Tetsuo Takehara

    BMC Cancer 2017 17:152

    Published on: 23 February 2017

  10. Research article

    High-dose chemotherapy and autologous stem cell transplantation of patients with multiple myeloma in an outpatient setting

    High-dose (HD) chemotherapy with melphalan and autologous blood stem cell transplantation (ABSCT) for treatment of symptomatic multiple myeloma (MM) on an outpatient basis has been well established in the USA ...

    Katharina Lisenko, Sandra Sauer, Thomas Bruckner, Gerlinde Egerer, Hartmut Goldschmidt, Jens Hillengass, Johann W. Schmier, Sofia Shah, Mathias Witzens-Harig, Anthony D. Ho and Patrick Wuchter

    BMC Cancer 2017 17:151

    Published on: 22 February 2017

  11. Research article

    Lower blood pressure and risk of cisplatin nephrotoxicity: a retrospective cohort study

    The pathophysiological mechanisms of cisplatin nephrotoxicity include the reduction of renal blood flow, as well as tubular epithelial cell toxicity. The objective of this study was to investigate the influenc...

    Kazumi Komaki, Tetsuro Kusaba, Mai Tanaka, Hiroshi Kado, Yayoi Shiotsu, Masahiro Matsui, Atsushi Shiozaki, Hiroshi Nakano, Takeshi Ishikawa, Hitoshi Fujiwara, Hideyuki Konishi, Yoshito Itoh, Satoaki Matoba and Keiichi Tamagaki

    BMC Cancer 2017 17:144

    Published on: 20 February 2017

  12. Research article

    Relationships between longitudinal neutrophil to lymphocyte ratios, body weight changes, and overall survival in patients with non-small cell lung cancer

    There is emerging evidence showing a significant relationship between overall survival (OS) in non-small cell lung cancer NSCLC patients and weight change during chemotherapy or chemoradiation. A high neutroph...

    B. A. Derman, J. N. Macklis, M. S. Azeem, S. Sayidine, S. Basu, M. Batus, F. Esmail, J. A. Borgia, P. Bonomi and M. J. Fidler

    BMC Cancer 2017 17:141

    Published on: 16 February 2017

  13. Research article

    Safety and efficacy of lobaplatin combined with 5-fluorouracil as first-line induction chemotherapy followed by lobaplatin-radiotherapy in locally advanced nasopharyngeal carcinoma: preliminary results of a prospective phase II trial

    Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasophar...

    Liang-Ru Ke, Wei-Xiong Xia, Wen-Ze Qiu, Xin-Jun Huang, Jing Yang, Ya-Hui Yu, Hu Liang, Guo-Ying Liu, Yan-Fang Ye, Yan-Qun Xiang, Xiang Guo and Xing Lv

    BMC Cancer 2017 17:134

    Published on: 15 February 2017

  14. Research article

    Clinicopathologic characteristics and prognostic factors for primary spinal epidural lymphoma: report on 36 Chinese patients and review of the literature

    Due to the uncommon nature of primary spinal epidural lymphomas (PSELs), there has been little research looking at prognostic indicators for the tumor. To our knowledge, this is the largest study to evaluate p...

    Le Xiong, Ling-Min Liao, Jian-Wu Ding, Zhi-Lin Zhang, An-Wen Liu and Long Huang

    BMC Cancer 2017 17:131

    Published on: 14 February 2017

  15. Research article

    The clinical picture of cachexia: a mosaic of different parameters (experience of 503 patients)

    Despite our growing knowledge about the pathomechanisms of cancer cachexia, a whole clinical picture of the cachectic patient is still missing. Our objective was to evaluate the clinical characteristics in can...

    S. Schwarz, O. Prokopchuk, K. Esefeld, S. Gröschel, J. Bachmann, S. Lorenzen, H. Friess, M. Halle and M. E. Martignoni

    BMC Cancer 2017 17:130

    Published on: 14 February 2017

  16. Research article

    Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement

    Skeletal involvement (SI) is observed at low prevalence in patients with diffuse large B-cell lymphoma (DLBCL). Due to the rareness of this particular condition, prospective trials for these patients are scarce.

    Nicola Lehners, Isabelle Krämer, Maral Saadati, Axel Benner, Anthony D. Ho and Mathias Witzens-Harig

    BMC Cancer 2017 17:128

    Published on: 13 February 2017

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