Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

Previous Page Page 1 of 37 Next Page
  1. Research article

    Simultaneous analysis of miRNA-mRNA in human meningiomas by integrating transcriptome: A relationship between PTX3 and miR-29c

    Although meningioma is a common disease, there is a lack of understanding of the underlying molecular mechanisms behind its initiation and progression. We used combined miRNA-mRNA transcriptome analysis to dis...

    Altay Burak Dalan, Sukru Gulluoglu, Emre Can Tuysuz, Aysegul Kuskucu, Cumhur Kaan Yaltirik, Oguz Ozturk, Ugur Ture and Omer Faruk Bayrak

    BMC Cancer 2017 17:207

    Published on: 21 March 2017

  2. Research article

    Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells

    Approximately 18–20% of all human breast cancers have overexpressed human epidermal growth factor receptor 2 (HER2). Standard clinical practice is to treat only overexpressed HER2 (HER2+) cancers with targeted...

    Yao Huang, David J. Burns, Benjamin E. Rich, Ian A. MacNeil, Abhijit Dandapat, Sajjad M. Soltani, Samantha Myhre, Brian F. Sullivan, Carol A. Lange, Leo T. Furcht and Lance G. Laing

    BMC Cancer 2017 17:199

    Published on: 16 March 2017

  3. Research article

    YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro

    Y-box binding protein-1 is an evolutionary conserved transcription and translation regulating protein that is overexpressed in various human malignancies, including breast cancer. Despite reports of YB-1 and i...

    Jia Pei Lim, Sukanya Shyamasundar, Jayantha Gunaratne, Olivia Jane Scully, Ken Matsumoto and Boon Huat Bay

    BMC Cancer 2017 17:201

    Published on: 16 March 2017

  4. Research article

    Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells

    Breast cancer is the main cause of mortality among women. The disease presents high recurrence mainly due to incomplete efficacy of primary treatment in killing all cancer cells. Photodynamic therapy (PDT), an...

    Ancély F. dos Santos, Letícia F. Terra, Rosangela A. M. Wailemann, Talita C. Oliveira, Vinícius de Morais Gomes, Marcela Franco Mineiro, Flávia Carla Meotti, Alexandre Bruni-Cardoso, Maurício S. Baptista and Leticia Labriola

    BMC Cancer 2017 17:194

    Published on: 15 March 2017

  5. Research article

    Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway

    Cancer cachexia is a multifactorial syndrome that dramatically decreases survival. Loss of white adipose tissue (WAT) is one of the key characteristics of cachexia. WAT wasting is paralleled by microarchitectu...

    Michele Joana Alves, Raquel Galvão Figuerêdo, Flavia Figueiredo Azevedo, Diego Alexandre Cavallaro, Nelson Inácio Pinto Neto, Joanna Darck Carola Lima, Emidio Matos-Neto, Katrin Radloff, Daniela Mendes Riccardi, Rodolfo Gonzalez Camargo, Paulo Sérgio Martins De Alcântara, José Pinhata Otoch, Miguel Luiz Batista Junior and Marília Seelaender

    BMC Cancer 2017 17:190

    Published on: 14 March 2017

  6. Research article

    Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target

    Most cancer deaths result from tumor cells that have metastasized beyond their tissue of origin, or have developed drug resistance. Across many cancer types, patients with advanced stage disease would benefit ...

    Cai M. Roberts, Sophia A. Shahin, Joana Loeza, Thanh H. Dellinger, John C. Williams and Carlotta A. Glackin

    BMC Cancer 2017 17:184

    Published on: 10 March 2017

  7. Research article

    miR-124 targets GATA6 to suppress cholangiocarcinoma cell invasion and metastasis

    Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied th...

    Feng Tian, Jian Chen, Shuguo Zheng, Dajiang Li, Xin Zhao, Peng Jiang, Jianwei Li and Shuguang Wang

    BMC Cancer 2017 17:175

    Published on: 7 March 2017

  8. Research article

    Is cancer a pure growth curve or does it follow a kinetics of dynamical structural transformation?

    Unperturbed tumor growth kinetics is one of the more studied cancer topics; however, it is poorly understood. Mathematical modeling is a useful tool to elucidate new mechanisms involved in tumor growth kinetic...

    Maraelys Morales González, Javier Antonio González Joa, Luis Enrique Bergues Cabrales, Ana Elisa Bergues Pupo, Baruch Schneider, Suleyman Kondakci, Héctor Manuel Camué Ciria, Juan Bory Reyes, Manuel Verdecia Jarque, Miguel Angel O’Farril Mateus, Tamara Rubio González, Soraida Candida Acosta Brooks, José Luis Hernández Cáceres and Gustavo Victoriano Sierra González

    BMC Cancer 2017 17:174

    Published on: 7 March 2017

  9. Research article

    miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene

    Loss of CBX7 expression has been described in several malignant neoplasias, including human colon and thyroid carcinomas proposing CBX7 as a tumor suppressor gene with a key role in cancer progression. This role ...

    Floriana Forzati, Marco De Martino, Francesco Esposito, Romina Sepe, Simona Pellecchia, Umberto Malapelle, Gianluca Pellino, Claudio Arra and Alfredo Fusco

    BMC Cancer 2017 17:170

    Published on: 4 March 2017

  10. Research article

    Metallothionein 1H (MT1H) functions as a tumor suppressor in hepatocellular carcinoma through regulating Wnt/β-catenin signaling pathway

    Metallothionein 1H (MT1H) expression level is downregulated in several kinds of tumors, including hepatocellular cancer (HCC). However, its biological functions and underlying mechanisms in HCC is largely unknown...

    Yulong Zheng, Lihua Jiang, Yongxian Hu, Cheng Xiao, Nong Xu, Jianying Zhou and Xinhui Zhou

    BMC Cancer 2017 17:161

    Published on: 28 February 2017

Previous Page Page 1 of 37 Next Page

Can't find what you are looking for?

The following sections have not yet been added to this new-look site. In the meantime you can still view them on our old site.