Cell and molecular biology

This section covers all aspects of tumor biology from a molecular and cellular point of view. Topics of interest include, but are not limited to, animal models, hypoxia, angiogenesis, metastasis, cellular signaling, cancer stem cells, DNA damage and repair, cell cycle and apoptosis.

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  1. Research article

    MiR-23b controls ALDH1A1 expression in cervical cancer stem cells

    Cancer stem cells has been widely investigated due to its essential role in cancer progression and drug resistance. Here, we try to find a new therapeutic target for cervical cancer stem cells.

    Weiwen Wang, Yang Li, Na Liu, Yu Gao and Long Li

    BMC Cancer 2017 17:292

    Published on: 27 April 2017

  2. Research article

    Down-regulated expression of OPCML predicts an unfavorable prognosis and promotes disease progression in human gastric cancer

    OPCML belongs to the IgLON family of Ig domain–containing GPI-anchored cell adhesion molecules and was recently found to be involved in carcinogenesis, while its role in gastric cancer remains unclear.

    Xiangbin Xing, Weibin Cai, Sanmei Ma, Yongfei Wang, Huijuan Shi, Ming Li, Jinxia Jiao, Yang Yang, Longshan Liu, Xiangliang Zhang and Minhu Chen

    BMC Cancer 2017 17:268

    Published on: 14 April 2017

  3. Research article

    Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device

    Migration of cancer cell correlates with distant metastasis and local invasion, which are good targets for cancer treatment. An optically accessible device “TAXIScan” was developed, which provides considerably...

    Akira Yamauchi, Masahiro Yamamura, Naoki Katase, Masumi Itadani, Naoko Okada, Kayoko Kobiki, Masafumi Nakamura, Yoshiyuki Yamaguchi and Futoshi Kuribayashi

    BMC Cancer 2017 17:234

    Published on: 31 March 2017

  4. Research article

    Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

    Recent investigations suggest role(s) of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer. Rat NAT2 is orthologous to human NAT1 and the gene products are functional homologs. We conducted in vivo st...

    Marcus W. Stepp, Mark A. Doll, David J. Samuelson, Mary Ann G. Sanders, J. Christopher States and David W. Hein

    BMC Cancer 2017 17:233

    Published on: 31 March 2017

  5. Research article

    u-PAR expression in cancer associated fibroblast: new acquisitions in multiple myeloma progression

    Multiple Myeloma (MM) is a B-cell malignancy in which clonal plasma cells progressively expand within the bone marrow (BM) as effect of complex interactions with extracellular matrix and a number of microenvir...

    S Ciavarella, A Laurenzana, S De Summa, B Pilato, A Chillà, R Lacalamita, C Minoia, F Margheri, A Iacobazzi, A Rana, F Merchionne, G Fibbi, M Del Rosso, A Guarini, S Tommasi and S Serratì

    BMC Cancer 2017 17:215

    Published on: 24 March 2017

  6. Research article

    Simultaneous analysis of miRNA-mRNA in human meningiomas by integrating transcriptome: A relationship between PTX3 and miR-29c

    Although meningioma is a common disease, there is a lack of understanding of the underlying molecular mechanisms behind its initiation and progression. We used combined miRNA-mRNA transcriptome analysis to dis...

    Altay Burak Dalan, Sukru Gulluoglu, Emre Can Tuysuz, Aysegul Kuskucu, Cumhur Kaan Yaltirik, Oguz Ozturk, Ugur Ture and Omer Faruk Bayrak

    BMC Cancer 2017 17:207

    Published on: 21 March 2017

  7. Research article

    Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells

    Approximately 18–20% of all human breast cancers have overexpressed human epidermal growth factor receptor 2 (HER2). Standard clinical practice is to treat only overexpressed HER2 (HER2+) cancers with targeted...

    Yao Huang, David J. Burns, Benjamin E. Rich, Ian A. MacNeil, Abhijit Dandapat, Sajjad M. Soltani, Samantha Myhre, Brian F. Sullivan, Carol A. Lange, Leo T. Furcht and Lance G. Laing

    BMC Cancer 2017 17:199

    Published on: 16 March 2017

  8. Research article

    YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro

    Y-box binding protein-1 is an evolutionary conserved transcription and translation regulating protein that is overexpressed in various human malignancies, including breast cancer. Despite reports of YB-1 and i...

    Jia Pei Lim, Sukanya Shyamasundar, Jayantha Gunaratne, Olivia Jane Scully, Ken Matsumoto and Boon Huat Bay

    BMC Cancer 2017 17:201

    Published on: 16 March 2017

  9. Research article

    Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells

    Breast cancer is the main cause of mortality among women. The disease presents high recurrence mainly due to incomplete efficacy of primary treatment in killing all cancer cells. Photodynamic therapy (PDT), an...

    Ancély F. dos Santos, Letícia F. Terra, Rosangela A. M. Wailemann, Talita C. Oliveira, Vinícius de Morais Gomes, Marcela Franco Mineiro, Flávia Carla Meotti, Alexandre Bruni-Cardoso, Maurício S. Baptista and Leticia Labriola

    BMC Cancer 2017 17:194

    Published on: 15 March 2017

  10. Research article

    Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway

    Cancer cachexia is a multifactorial syndrome that dramatically decreases survival. Loss of white adipose tissue (WAT) is one of the key characteristics of cachexia. WAT wasting is paralleled by microarchitectu...

    Michele Joana Alves, Raquel Galvão Figuerêdo, Flavia Figueiredo Azevedo, Diego Alexandre Cavallaro, Nelson Inácio Pinto Neto, Joanna Darck Carola Lima, Emidio Matos-Neto, Katrin Radloff, Daniela Mendes Riccardi, Rodolfo Gonzalez Camargo, Paulo Sérgio Martins De Alcântara, José Pinhata Otoch, Miguel Luiz Batista Junior and Marília Seelaender

    BMC Cancer 2017 17:190

    Published on: 14 March 2017

  11. Research article

    Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target

    Most cancer deaths result from tumor cells that have metastasized beyond their tissue of origin, or have developed drug resistance. Across many cancer types, patients with advanced stage disease would benefit ...

    Cai M. Roberts, Sophia A. Shahin, Joana Loeza, Thanh H. Dellinger, John C. Williams and Carlotta A. Glackin

    BMC Cancer 2017 17:184

    Published on: 10 March 2017

  12. Research article

    miR-124 targets GATA6 to suppress cholangiocarcinoma cell invasion and metastasis

    Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied th...

    Feng Tian, Jian Chen, Shuguo Zheng, Dajiang Li, Xin Zhao, Peng Jiang, Jianwei Li and Shuguang Wang

    BMC Cancer 2017 17:175

    Published on: 7 March 2017

  13. Research article

    Is cancer a pure growth curve or does it follow a kinetics of dynamical structural transformation?

    Unperturbed tumor growth kinetics is one of the more studied cancer topics; however, it is poorly understood. Mathematical modeling is a useful tool to elucidate new mechanisms involved in tumor growth kinetic...

    Maraelys Morales González, Javier Antonio González Joa, Luis Enrique Bergues Cabrales, Ana Elisa Bergues Pupo, Baruch Schneider, Suleyman Kondakci, Héctor Manuel Camué Ciria, Juan Bory Reyes, Manuel Verdecia Jarque, Miguel Angel O’Farril Mateus, Tamara Rubio González, Soraida Candida Acosta Brooks, José Luis Hernández Cáceres and Gustavo Victoriano Sierra González

    BMC Cancer 2017 17:174

    Published on: 7 March 2017

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