Volume 7 Supplement 1

24thAnnual Meeting of the National Cancer Institute of Mexico

Open Access

Survival among AIDS patients with and without non-Hodgkin's lymphoma, and NHL-HIV-negative patients

  • Patricia Cornejo-Juárez1Email author,
  • Patricia Volkow-Fernández1,
  • Alejandro Avilés-Salas2 and
  • Ernesto Calderón-Flores3
BMC Cancer20077(Suppl 1):A40

DOI: 10.1186/1471-2407-7-S1-A40

Published: 5 February 2007

Background

The risk of non Hodgkin's lymphoma (NHL) is 150–250 times higher among HIV infected patients. In developed countries with open access to highly active antiretroviral therapy (HAART), the prognosis of these patients appears to be impacted positively, and survival in some groups can be similar to non-HIV infected patients. Recent data has shown improved survival among NHL-HIV+ patients receiving standard chemotherapy (QT) HAART, with acceptable range of toxicity.

Objective

To analyze the median survival of patients with AIDS with and without NHL and NHL-HIV negative patients.

Materials and methods

We etrospectively reviewed all medical records of patients with NHL-HIV+ seen from January 1990 to December 2005 at the Instituto Nacional de Cancerologia in Mexico City, Mexico. We used as control groups patients with AIDS (defining-event non-lymphoma related), and patients with NHL treated as well at our institution, diagnosis made ± 3 years, with same gender and age ± 5 years. We recorded clinical, laboratory and pathology data; survival or follow-up time was calculated from date of diagnosis to death or to the date when the patient was last seen.

Results

Sixty-nine patients were diagnosed with NHL-HIV. AIDS control patients (n = 93) were divided into no-HAART and HAART; and NHL/HIV negative control patients (n = 90) were divided into incomplete (<3 cycles or <100% of total dose), and complete chemotherapy (Table 1)
Table 1

Mean survival for NHL/HIV+, NHL/HIV negative and AIDS groups

 

NHL/HIV+ (n = 69)

AIDS (n = 93)

p

No-HAART (months ± SD)

5.01 ± 7.7 (n = 27)

25.9 ± 25.12 (n = 40)

0.001

HAART (months ± SD)

15.75 ± 19.4 (n = 42)

50 ± 37.9 (n = 53)

<0.0001

Total (months ± SD)

11.5 ± 16.7

39.7 ± 35

<0.0001

 

NHL/HIV

NHL (n = 90)

 

Incomplete chemotherapy (months ± SD)

4.32 ± 5.5 (n = 40)

1.84 ± 1.66 (n = 22)

0.04

Complete chemotherapy(months ± SD)

21.3 ± 20.26 (n = 29)

29.07 ± 36.27 (n = 68)

0.286

Total(months ± SD)

11.5 ± 16.7

22.41 ± 33.61

0.01

Conclusion

Survival in patients with AIDS is better than in NHL/HIV+ and NHL/HIV-. The use of HAART has significantly improved sthe prognosis. Mean survival with the use of a complete chemotherapy regime is similar in patients with NHL and in patients with NHL/HIV+.

Authors’ Affiliations

(1)
Department of Infectious Diseases, Instituto Nacional de Cancerología
(2)
Department of Pathology, Instituto Nacional de Cancerología
(3)
Department of Hematology-Oncology, Instituto Nacional de Cancerología

Copyright

© Cornejo-Juárez et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.

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