Histological review of skin cancers in African Albinos: a 10-year retrospective review
© Kiprono et al.; licensee BioMed Central Ltd. 2014
Received: 30 January 2013
Accepted: 28 February 2014
Published: 6 March 2014
Skin cancer is rare among Africans and albinism is an established risk for skin cancer in this population. Ultraviolet radiation is highest at the equator and African albinos living close to the equator have the highest risk of developing skin cancers.
This was a retrospective study that involved histological review of all specimens with skin cancers from African albinos submitted to The Regional Dermatology Training Center in Moshi, Tanzania from 2002 to 2011.
A total of 134 biopsies from 86 patients with a male to female ratio of 1:1 were reviewed. Head and neck was the commonest (n = 75, 56.0%) site affected by skin cancers. Squamous cell carcinoma (SCC) was more common than basal cell carcinoma (BCC) with a ratio of 1.2:1. Only one Acral lentiginous melanoma was reported. Majority (55.6%) of SCC were well differentiated while nodular BCC (75%) was the most common type of BCC.
Squamous cell carcinoma is more common than basal cell carcinoma in African albinos.
KeywordsAlbinos African Skin Cancer
Skin cancer is the most common malignancy among Caucasians. It represents approximately 20-30% of all neoplasms in Caucasians and 1-2% in those with colored skin . Skin cancer is a major cause of morbidity and mortality in Albinos who develop premalignant and malignant lesions at a younger age and suffer from advanced skin cancers in the third to fourth decade of life [2, 3].
Albinism is a genetically inherited disorder with a worldwide distribution. Phenotypically it presents with reduced or no melanin in the hair, the skin and the eyes . Genetically albinism is classified into four types according to the type of gene mutation . Oculocutaneous albinism type II (OCAII) is the most common type of albinism in Africa . The prevalence is estimated to range from 1 in 15,000 in the East-Central State of Nigeria  to 1 in 1,000 in the Tonga tribe of Zimbabwe . The prevalence in Tanzania is estimated to be 1 in 2,500 inhabitants . The lack of melanin and exposure to intense ultraviolet radiation increase the risk of developing skin cancer. The lack of melanin in Albinos increases the risk of developing skin cancer by 1,000 fold as compared with the general African population . The aim of this study was to determine the common type of skin cancers and if there is an increase in prevalence of squamous cell carcinoma using biopsies and excisions from Albinos.
This study was conducted at the Regional Dermatology Training Center (RDTC) at the Kilimanjaro Christian Medical Center. This is a referral hospital for skin diseases in Northern Tanzania with a catchment area population extending to the neighboring countries. This was a retrospective study covering a period of 10 years (from 2002 to 2011). All files of patients who were biopsied or whose tumors had been excised and submitted for histopathological examination were retrieved and a structured data collection tool was used to extract the data. Data was entered into a statistical package for social scientists (SPPSS Chicago Inc.) for descriptive analysis. Ethical clearance was waived by the Kilimanjaro Christian Medical College Ethical Committee. All slides were examined by a dermatopathologist. In case the slides were missing or damaged, new slides were prepared from the stored blocks.
Squamous cell carcinoma (SCC) was classified in three categories according to the most poorly differentiated site within each specimen :
Well differentiated: Squamous epithelium with easily recognizable and abundant keratinization. Nuclear and cellular pleomorphism is minimal while mitotic figures are few and basally located.
Moderately differentiated: Structural disorganization of squamous epithelium with pronounced pleomorphism and more mitotic figures. Keratinization is limited to keratin pearls.
Poorly differentiated: Anaplastic tumor with foci of keratinization or originating from the surface epithelium.
Characteristics of 134 skin cancers from biopsies and excisions in Albinos
Type of the tumor (n = 134)
Squamous cell carcinomas (SCCs)
Basal cell carcinomas (BCCs)
Type of SCCs
Type of BCCs
This study is the largest histological review of skin cancers in African albinos. Previous studies reported results from small sample size with the largest study involving 64 cases (8). Albinos living close to the equator develop sun damage earlier in life because of lack of sun protection and they develop premalignant and malignant tumors by the second decade of life. Previous studies from Nigeria  and Tanzania  reported that only a few Albinos survived beyond 30 years. However, the findings from this study showed a mean age of 35 years (SD ± 10.6) representing an increase in the survival rate, which could be due to improved awareness and early management of skin cancer in general, and in particular this could be a positive consequence of the ongoing Albino outreach program in the RDTC since 1993.
All the tumors were non- melanoma skin cancers (NMSCs) except for one case of melanoma. This overwhelming predominance of NMSCs over melanoma has also been observed in Caucasians. The incidence of NMSCs is reported to be 18 - 20 times that of malignant melanoma . Non- melanoma skin cancers mainly affect older individuals, while the frequency of melanoma peaks at 20-45 years . The age of the majority of the patients in this study was within the peak age for melanoma, but much lower for NMSCs. This observation indicates that melanoma is rare in Albinos, a finding that has also been reported in other studies [9, 10]. The relationship between the exposure to ultraviolet radiation and the risk for developing melanoma is not clear-cut and the incidence rates relate to the latitude to a lesser extent than that for NMSCs . The complex association between the exposure to ultraviolet radiation and other factors including genetic factors may explain the low melanoma incidence.
The majority of NMSCs in Caucasians are BCCs and SCCs. The incidence of BCCs is estimated to be 4 times higher than that for SCCs . In contrast to this study, there were more SCCs than BCCs with BCCs to SCCs ratio of 1:1.2. Previous studies have reported the predominance of SCCs in Albinos with SCCs occurring 3 - 6 times more than BCCs [9, 10, 13–15]. The relatively high predominance of SCCs over BCCs in those studies could have been due to the small sample sizes in which four studies had less than 20 patients. Those studies were also based on excisional biopsies from advanced tumors, whereas biopsies in this study were obtained from patients undergoing routine dermatological examination and advanced tumors. The slowly growing small BCC may have been missed in previous studies. High cumulative dose of ultraviolet radiation is associated with the development of SCCs. The incidence of SCCs doubles for every 8-10 degrees decline in the latitude with the maximum incidence at the equator . The ultraviolet dose per unit time at the equator is about 200% of that in Europe or Northern USA .
Skin cancers generally develop at body sites exposed to ultraviolet radiation [9, 10, 12]. A significant number (40) of skin tumors occurred on the trunk. The hot weather conditions and the farming activities in this community limit the use of proper sun protective clothing, which may increase the incidence of skin cancers on the otherwise sun protected areas.
The mean duration of skin cancer before seeking medical care of 14.4 months was almost similar to the 17.9 months reported by Alexander and Henschke  30 years ago. The delay in seeking medical treatment for skin cancer of a mean of 26 months was also reported in Nigeria . Albinos also face social discrimination  and have difficulties in formal education because of poor eyesight . Poverty, illiteracy and social discrimination contribute in the delay to seek medical care especially for skin cancer. This study was based on biopsies or tumor excisions that underwent histopathological examination. However, tumors that were excised, but not submitted for histopathological examination or not biopsied were missed. Therefore, this study may be biased.
Non-melanoma skin cancers are overwhelmingly predominant in Albinos. The proportion of SCCs and BCCs is almost identical. These occur at a younger age, but there is a considerable patient delay in seeking medical care.
Written informed consent was obtained from the patient for publication of this image.
We thank Prof. Ben Naafs for critically reading the manuscript and Dr Bob Tank for correcting the English.
- Gloster HM, Neal K: Skin cancer in skin of color. J Am Acad Dermatol. 2006, 55: 741-760. 10.1016/j.jaad.2005.08.063.View ArticlePubMedGoogle Scholar
- Okoro AN: Albinism in Nigeria: a clinical and social study. Br J Dermatol. 1975, 92: 485-492.View ArticlePubMedGoogle Scholar
- Luande J, Henschke CI, Mohammed N: The Tanzanian human albino skin: natural history. Cancer. 1985, 55: 1823-1828. 10.1002/1097-0142(19850415)55:8<1823::AID-CNCR2820550830>3.0.CO;2-X.View ArticlePubMedGoogle Scholar
- Grønskov K, Ek J, Brondum-Nielsen K: Oculocutaneous albinism. Orphanet J Rare Dis. 2007, 2: 43-50. 10.1186/1750-1172-2-43.View ArticlePubMedPubMed CentralGoogle Scholar
- Lund PM, Puri N, Durham-Pierre D, King RA, Brilliant MH: Oculocutaneous albinism in an isolated Tonga community in Zimbabwe. J Med Genet. 1997, 34: 733-735. 10.1136/jmg.34.9.733.View ArticlePubMedPubMed CentralGoogle Scholar
- Higgenson J, Oettle AG: Cancer in the South African Bantu. J Natl Canc Inst. 1960, 24: 643-647.Google Scholar
- Brenn T, McKee PH: Tumors of surface epithelium. Pathology of the Skin. Edited by: McKee PH, Calonje E, Granter SR. 2007, Philadelphia: Elsevier Mosby, 1199-1207. 3Google Scholar
- Diepgen TL, Mahler V: The epidemiology of skin cancer. Br J Dermatol. 2002, 146 (61): 1-6.View ArticlePubMedGoogle Scholar
- Mabula JB, Chalya PL, Mchembe MD, Jaka H, Giiti G, Rambau P, et al: Skin cancers among albinos at a University teaching hospital in North-Western Tanzania: a retrospective review of 64 cases. BMC Dermatol. 2012, 12: 5-10.1186/1471-5945-12-5. 10.1186/1471-5945-12-5View ArticlePubMedPubMed CentralGoogle Scholar
- Opara KO, Jiburum BC: Skin cancers in albinos in a teaching hospital in Eastern Nigeria - presentation and challenges of care. World J Surg Oncol. 2010, 8: 73-79. 10.1186/1477-7819-8-73.View ArticlePubMedPubMed CentralGoogle Scholar
- Rigel DS: Cutaneous ultraviolet exposure and its relationship to the development of skin cancer. J Am Acad Dermatol. 2008, 58: S129-S132. 10.1016/j.jaad.2007.04.034.View ArticlePubMedGoogle Scholar
- Ridky TW: Nonmelanoma skin cancer. J Am Acad Dermatol. 2007, 57: 484-501. 10.1016/j.jaad.2007.01.033.View ArticlePubMedGoogle Scholar
- Yakubu A, Mabogunje OA: Skin cancer in African albinos. Acta Oncol. 1993, 32: 621-622. 10.3109/02841869309092440.View ArticlePubMedGoogle Scholar
- Kromberg JG, Castle D, Zwane EM: Albinism and skin cancer in southern Africa. Clin Genet. 1989, 36: 43-52.View ArticlePubMedGoogle Scholar
- Alexander GA, Henschke UK: Advanced skin cancer among Tanzanian Albinos: preliminary observation. J Natl Med Assoc. 1981, 17 (11): 1047-1054.Google Scholar
- Fears TR: Estimating increase in skin cancer morbidity due to increase in ultraviolet radiation exposure. Canc Invest. 1983, 1: 119-126. 10.3109/07357908309042414.View ArticleGoogle Scholar
- McBride SR, Leppard BJ: Attitudes and beliefs of an Albino population toward sun avoidance, advice and services provided by an outreach albino clinic in Tanzania. Arch Dermatol. 2002, 138: 629-632.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/14/157/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.