Differences in the symptom experience of older versus younger oncology outpatients: a cross-sectional study

  • Janine K Cataldo1,

    Affiliated with

    • Steven Paul1,

      Affiliated with

      • Bruce Cooper1,

        Affiliated with

        • Helen Skerman3,

          Affiliated with

          • Kimberly Alexander3,

            Affiliated with

            • Bradley Aouizerat1, 4,

              Affiliated with

              • Virginia Blackman1,

                Affiliated with

                • John Merriman1,

                  Affiliated with

                  • Laura Dunn2,

                    Affiliated with

                    • Christine Ritchie2,

                      Affiliated with

                      • Patsy Yates3 and

                        Affiliated with

                        • Christine Miaskowski1, 5Email author

                          Affiliated with

                          BMC Cancer201313:6

                          DOI: 10.1186/1471-2407-13-6

                          Received: 20 December 2012

                          Accepted: 20 December 2012

                          Published: 3 January 2013

                          Abstract

                          Background

                          Mortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood. One explanation may be that older patients received substandard treatment because of concerns about adverse effects. Given the paucity of research on the multiple dimensions of the symptom experience in older oncology patients, the purpose of this study was to evaluate for differences in ratings of symptom occurrence, severity, frequency, and distress between younger (< 60 years) and older ( ≥ 60 years) adults undergoing cancer treatment. We hypothesized that older patients would have significantly lower ratings on four symptom dimensions.

                          Methods

                          Data from two studies in the United States and one study in Australia were combined to conduct this analysis. All three studies used the MSAS to evaluate the occurrence, severity, frequency, and distress of 32 symptoms.

                          Results

                          Data from 593 oncology outpatients receiving active treatment for their cancer (i.e., 44.4% were < 60 years and 55.6% were ≥ 60 years of age) were evaluated. Of the 32 MSAS symptoms, after controlling for significant covariates, older patients reported significantly lower occurrence rates for 15 (46.9%) symptoms, lower severity ratings for 6 (18.9%) symptoms, lower frequency ratings for 4 (12.5%) symptoms, and lower distress ratings for 14 (43.8%) symptoms.

                          Conclusions

                          This study is the first to evaluate for differences in multiple dimensions of symptom experience in older oncology patients. For almost 50% of the MSAS symptoms, older patients reported significantly lower occurrence rates. While fewer age-related differences were found in ratings of symptom severity, frequency, and distress, a similar pattern was found across all three dimensions. Future research needs to focus on a detailed evaluation of patient and clinical characteristics (i.e., type and dose of treatment) that explain the differences in symptom experience identified in this study.

                          Keywords

                          Geriatric oncology Symptoms

                          Background

                          Cancer is predominantly an older person’s illness. Approximately 50% of the most common cancers (i.e., breast, prostate, and lung) occur in people over 60 years of age [1]. Because of major advances in cancer treatment and supportive care strategies, a larger percentage of older persons are receiving active treatment [2]. However, while mortality rates for cancer are decreasing in patients under 60, they are increasing in those over 60 years of age [1]. The reasons for these differences in mortality rates remain poorly understood primarily due to the paucity of research on older persons with cancer.

                          Older adults are a vulnerable population who are at high risk for suboptimal cancer care because they were under-represented in clinical trials and experience disparities in cancer treatment [37]. One reason why mortality rates may be increasing in patients over 60 is that they receive substandard treatment (i.e., lower doses of radiation therapy (RT) or chemotherapy (CTX)) because of the unsubstantiated belief that they will experience a larger number and more severe adverse effects as well as poor functional outcomes and significant decrements in quality of life (QOL) [8, 9]. The foundations for these beliefs include the normal physiological changes that occur with aging that could influence drug metabolism, the co-occurrence of multiple co-morbidities in the elderly, and the increased risk of adverse effects associated with polypharmacy [2, 10, 11]. However, findings from studies on the impact of co-morbidities and cancer treatment on older people are contradictory [1214].

                          In addition, in the limited number of studies that evaluated associations between age and the occurrence and severity of physical and psychological symptoms, the results are inconsistent. In a study of oncology patients undergoing RT [15], sleep disturbance, pain, and distress were significantly less prevalent among older patients compared to younger patients, while shortness of breath was significantly more prevalent among older patients before RT. In another study of newly diagnosed cancer patients [16], age was weakly correlated with ratings of symptom distress (r = −0.11, p < 0.02) and older patients reported lower levels of symptom distress. In contrast, in a study of multiple symptoms [17], patients over 70 reported higher symptom distress scores than patients less than 40 years of age. In a study of patients with advanced cancer [10], compared to older patients, younger patients reported higher pain severity scores and better appetite. In terms of psychological symptoms, older age is consistently associated with lower levels of psychological distress regardless of clinical factors [1821]. However, less is known about how older patients experience psychological distress associated with cancer and its treatment [22, 23].

                          In both Australia and the United States, the number of oncology patients over the age of 60 is growing exponentially [1, 24]. In fact, estimates suggest that by 2030, the incidence of cancer among older adults will increase by 67% [25]. If research studies are not done to characterize the symptom management needs of older persons with cancer, the medical systems in both countries will not be prepared to provide the supportive care interventions that these highly vulnerable patients need in order to receive appropriate treatments and survive their cancer. Therefore, given the paucity of research on age-related differences in the multiple dimensions of the symptom experience, the purpose of this study, using the Memorial Symptom Assessment Scale (MSAS) [26], was to evaluate for differences in ratings of symptom occurrence, severity, frequency, and distress between younger (< 60 years) and older (≥ 60 years) adults undergoing cancer treatment. Based on previous studies [16, 2729], we hypothesized that older patients would have significantly lower ratings on all symptom dimensions than younger patients.

                          Methods

                          Study samples

                          Demographic, clinical, and symptom data from one Australian study (i.e., Symptom Clusters) and two United States studies (i.e., Fatigue, Pain, and Sleep Study (FPS study), Symptom Prevalence Study) were combined to conduct this analysis. All three studies enrolled patients who were receiving active treatment for their cancer. To evaluate the effect of age, patients were dichotomized into younger (< 60) and older (≥ 60) groups based on cut-offs used in previous studies of cancer symptoms [10, 30, 31], as well as findings that cancer mortality rates are increasing in those > 60 years [1].

                          Symptom clusters study

                          This prospective, longitudinal study was designed to identify symptom clusters and their effects on physical and psychological functioning of patients with metastatic disease. Data were collected from patients using an interview-administered survey at the time of diagnosis or progression of metastatic disease and again at 2 months and 4 months. Data from the first assessment were used in these analyses.

                          Patients were recruited consecutively from two major tertiary referral hospitals in Australia: the Royal Brisbane and Women’s Hospital and Peter MacCallum Cancer Centre (Melbourne). Patients were to participate if they: were adults (> 18 years of age) who could read, write, and understand English; had no cognitive limitations; had a primary cancer of breast, lung, colon/rectum, prostate, upper gastrointestinal tract, or ovaries; and were diagnosed with metastatic disease in the past month or had clinical evidence of progressive metastatic disease. Patients were excluded if they had local recurrence, but no evidence of metastatic disease; had a prognosis of < 4 months as determined by their clinician; or had physical or cognitive impairments that precluded participation in the 15-minute survey. The study was approved by the Ethics Committees of Queensland University of Technology and the two participating hospitals.

                          Research staff liaised with clinical staff to identify potentially eligible patients, using a standard screening assessment sheet. All patients provided written consent prior to completing the study questionnaires. Of 306 patients approached, 218 patients were recruited (71.2% response rate). Reasons for non-participation included: a clinician assessed that patients were not well enough to participate (27.9%), prognosis < 4 months (22%), limited English (18.7%), patient was currently participating in another study (18.4%), and physically or cognitively unable to participate (13%). The questionnaire was completed during a 20 minute face-to-face interview conducted by trained interviewers with nursing or psychology backgrounds. Clinical and demographic data were obtained from medical record reviews.

                          FPS study

                          This longitudinal study evaluated multiple symptoms in patients who underwent primary or adjuvant RT. Patients were recruited from two RT departments located in a Comprehensive Cancer Center and a community-based oncology program at the time of the patient’s simulation visit. Patients were eligible to participate if they: were ≥ 18 years of age; were scheduled to receive primary or adjuvant RT for one of four cancer diagnoses (i.e., breast, prostate, lung, brain); were able to read, write, and understand English; gave written informed consent; and had a Karnofsky Performance Status (KPS) score of ≥ 60. Patients were excluded if they had: metastatic disease, more than one cancer diagnosis, or a diagnosed sleep disorder.

                          A total of 472 patients were approached and 185 consented to participate (response rate of 34%). The primary reasons for refusal were being overwhelmed or too busy. The study was approved by the Committee on Human Research at the University of California, San Francisco (UCSF) and at the second site. At the time of the simulation visit (i.e., approximately one week prior to the initiation of RT), patients were approached by a research nurse to discuss participation in the study. After obtaining written informed consent, patients completed the study questionnaires. In addition, medical records were reviewed for disease and treatment information.

                          Symptom prevalence study

                          This descriptive, cross-sectional study used self-report questionnaires to obtain information from a convenience sample of oncology outpatients. Patients were recruited from four outpatient settings in Northern California, including a university-based Cancer Center, a Veterans Affairs facility, and two community-based outpatient clinics. Patients were eligible to participate if they were > 18 years of age; were able to read, write, and understand English; gave written, informed consent; had KPS scores of ≥ 50; and were receiving active cancer treatment.

                          A total of 310 patients were approached and 206 consented to participate (response rate of 66%). The primary reasons for refusal were that a patient was too ill to participate (80%), too busy (15%), or not interested in the research study (5%). Patients who agreed to participate provided written informed consent and were given a copy of the questionnaire booklet. They completed the study questionnaires in their home and returned them to the research office using a postage paid envelope. The study was approved by the Committee on Human Research at UCSF and at each of the study sites.

                          Instruments

                          Demographic and clinical characteristics

                          Demographic information on age, gender, marital status, and living arrangements were obtained at enrollment. Because of differences in the educational systems in Australia and the United States, data on education were recoded into a dichotomous variable (i.e., no post high school versus post high school education). In addition, patients’ medical records were reviewed for cancer diagnosis, presence of metastatic disease, and current treatment regimens (i.e., none, CTX, RT, or both CTX and RT).

                          In the Australian study, patient’s functional status was rated by their clinician using the Eastern Cooperative Oncology Group (ECOG) Performance Status score that ranges from 0 (fully active) to 4 (disabled) [32]. In the United States studies, patients rated their functional status using the KPS scale that ranged from 30 (I feel severely disabled and need to be hospitalized) to 100 (I feel normal; I have no complaints or symptoms). The KPS scale is widely used to evaluate functional status in patients with cancer and has well established validity and reliability. Based on the recommendations of Verger and colleagues [33], the KPS scores were converted to ECOG scores for use in subsequent analyses.

                          Memorial Symptom Assessment Scale (MSAS)

                          All three studies used the MSAS to evaluate the occurrence, severity, frequency, and distress of 32 symptoms commonly associated with cancer and its treatment [26]. The MSAS is a self-report questionnaire designed to measure the multidimensional experience of symptoms. Using the MSAS, patients were asked to indicate whether or not they had experienced each symptom in the past week (i.e., symptom occurrence). If they had experienced the symptom, they were asked to rate its frequency of occurrence, severity, and distress. Symptom frequency was evaluated using a 4-point Likert scale (i.e., 1 = rarely, 2 = occasionally, 3 = frequently, 4 = almost constantly). Symptom severity was measured using a 4-point Likert scale (i.e., 1 = slight, 2 = moderate, 3 = severe, 4 = very severe). Symptom distress was measured using a 5-point Likert scale (i.e., 0 = not at all, 1 = a little bit, 2 = somewhat, 3 = quite a bit, 4 = very much). Three subscale scores (i.e., physical, psychological, global distress index) and a total MSAS score were calculated. The reliability and validity of the MSAS is well established in studies of oncology inpatients and outpatients [26, 34]. Cronbach’s alphas for the total sample, as well as for patients < 60 years and ≥ 60 years are as follows: physical subscale (.82, .82, .82), psychological subscale (.81, .80, .77), global distress index (.82, .80, .83), and total MSAS score (.88, .89, .87).

                          Analysis

                          The three data sets were combined and data were analyzed using SPSS version 19 and STATA SE Version 12. Descriptive statistics, means, and standard deviations for quantitative variables and frequencies and percentages for categorical variables were generated to describe various patient characteristics. Mean ratings of severity, frequency, and distress were calculated for those patients who reported the symptom. Because previous studies have dichotomized older and younger patients at age 60 [10, 30, 31], older patients were defined as adults ≥ 60 years of age. Independent sample t-tests and Chi Square analyses were used to evaluate for differences in demographic and clinical characteristics between the two age groups. Differences between the two age groups in characteristics with multiple levels (i.e., diagnosis, treatment, ECOG Performance Status score) were further examined using post-hoc contrasts with Bonferroni correction.

                          Logistic regression was used to evaluate the effect of increasing age on the occurrence rates of each symptom. Significant differences, between the two age groups (< 60 (younger) and ≥ 60 (older) years of age), in the occurrence rates of each symptom were evaluated with binary logistic regression analyses. To examine the differences between the two age groups in the severity, frequency, and distress ratings of each symptom, ordinal logistic regression was utilized. Significant differences, between the two age groups (< 60 (younger) and ≥ 60 (older) years of age), in the MSAS subscale and total scores were evaluated with linear regression analyses. For all of the regression analyses, unadjusted and adjusted values (e.g., odds ratios and their corresponding 95% confidence intervals) were generated for each symptom or scale score.

                          Results

                          Differences in demographic and clinical characteristics between older and younger patients

                          As shown in Table 1, data from 593 oncology outpatients (i.e., 44.4% were < 60 years and 55.6% were ≥ 60 years of age) were evaluated. No differences were found across the three studies, in the age distribution of the patients. In addition, no differences were found, across the three studies, in the mean age of the patients (i.e., Symptom Clusters Study = 62.2 (± 12.0) years, FPS Study = 60.8 (± 12.0) years, Symptom Prevalence Study = 60.8 (± 12.4) years; F(2,590) = .994, p = .371). Across the three studies, the age distribution in 10 year increments was: 20 to 29 = 0.8%, 30 to 39 = 4.2%, 40 to 49 = 12.0%, 50 to 59 = 27.3%, 60 to 69 = 29.0%, 70 to 79 = 21.4%, and ≥ 80 = 5.3%.
                          Table 1

                          Demographic and clinical characteristics for the total sample and differences between younger (< 60, n = 263) and older (≥ 60, n = 330) patients

                          Characteristic

                          Total(%)

                          Age group

                          p-value

                          Post hoc contrasts

                          < 60(%)

                          ≥ 60(%)

                          < 60(%)

                          ≥ 60(%)

                          p-value

                          Study project

                                 

                           Fatigue, Pain, and Sleep

                          28.8

                          28.9

                          28.8

                          .170

                             

                           Symptom Prevalence

                          34.4

                          38.0

                          31.5

                              

                           Symptom Clusters

                          36.8

                          33.1

                          39.7

                              

                          Gender- Female

                          54.6

                          70.7

                          41.8

                          < .001

                             

                          Lives alone

                          26.4

                          24.0

                          28.2

                          .260

                             

                          Partnered/married

                          60.9

                          57.3

                          63.7

                          .126

                             

                          Education – Post high school

                          61.4

                          68.8

                          55.5

                          .001

                             

                          Diagnosis

                                 

                           Breast

                          33.6

                          48.3

                          21.8

                           

                          48.3

                          21.8

                          .0125

                           Prostate

                          26.0

                          11.0

                          37.9

                          < .001

                          11.0

                          37.9

                          .0125

                           Lung

                          13.2

                          11.4

                          14.5

                              

                           Other

                          27.3

                          29.3

                          25.8

                              

                          Metastases

                          34.9

                          37.3

                          32.9

                          .297

                             

                          Treatment

                                 

                           None

                          15.5

                          13.3

                          17.3

                              

                           Only radiation

                          43.6

                          33.8

                          51.4

                          < .001

                          33.8

                          51.4

                          .0125

                           Only chemotherapy

                          27.4

                          31.2

                          24.3

                              

                           Both

                          13.5

                          21.7

                          7.0

                           

                          21.7

                          7.0

                          .0125

                          ECOG Performance Status

                                 

                           Fully active

                          21.4

                          15.8

                          26.0

                           

                          15.8

                          26.0

                          .0100

                           Ambulatory, light work

                          48.9

                          53.1

                          45.5

                          .043

                             

                           Ambulatory, mobile > 50%

                          21.6

                          23.5

                          20.1

                              

                           Ambulatory, mobile < 50%

                          7.2

                          6.5

                          7.7

                              

                           Disabled

                          0.9

                          1.2

                          0.6

                              

                          Age (years; mean (standard deviation))

                          61.3 (12.1)

                          50.3 (7.7)

                          70.1 (6.5)

                          < .001

                             

                          Abbreviation: ECOG, Eastern Cooperative Oncology Group.

                          The mean age of the entire sample was 61.3 (±12.1) years. On average, younger patients were 50.3 (±7.7) and older patients were 70.1 (±6.5) years of age (p < .001). Older patients were: more likely to be male (p < .001); less likely to have finished high school; more likely to have prostate cancer (p < .001); more likely to be receiving RT (p < .001), and more likely to be fully active (p = .04).

                          Differences in symptom occurrence rates between older and younger patients

                          Table 2 provides the symptom occurrence rates for the total sample for each of the MSAS symptoms, as well as the unadjusted and adjusted odds of symptom occurrence as age increases by one year. After controlling for significant covariates (i.e., gender, education, diagnosis, treatment, and ECOG performance status), as age increased, significantly lower occurrence rates were reported for difficulty concentrating, pain, feeling nervous, nausea, difficulty sleeping, feeling bloated, vomiting, feeling sad, sweats, worrying, problems with sexual interest, feeling irritable, I don’t look like myself, and changes in skin.
                          Table 2

                          Symptom occurrence rates for the total sample and odds of symptom occurrence as age increases by one year

                          Symptom

                          Occurrence rates(%)for total sample

                          Unadjusted values

                          Adjusted values

                          Continuous age

                          Continuous age

                          Odds ratio

                          CI

                          Odds ratio

                          CI

                          Difficulty concentrating

                          45.9

                          .96+

                          .95-.97

                          .97+

                          .96-.99

                          Pain

                          64.1

                          .97+

                          .96-.98

                          .97**

                          .96-.99

                          Lack of energy

                          74.7

                          .98**

                          .96-.99

                          .99

                          .97-1.01

                          Cough

                          37.6

                          1.00

                          .98-1.01

                          1.00

                          .98-1.02

                          Feeling nervous

                          32.4

                          .98**

                          .96-.99

                          .98*

                          .97-.99

                          Dry mouth

                          42.8

                          1.00

                          .99-1.01

                          1.01

                          .99-1.03

                          Nausea

                          31.2

                          .98**

                          .97-.99

                          .98*

                          .97-.99

                          Feeling drowsy

                          58.7

                          .99

                          .97-1.00

                          .99

                          .98-1.01

                          Numbness/tingling in hands/feet

                          31.9

                          .99

                          .97-1.00

                          .99

                          .98-1.01

                          Difficulty sleeping

                          53.3

                          .96+

                          .95-.98

                          .97**

                          .96-.99

                          Feeling bloated

                          24.8

                          .97+

                          .95-.98

                          .97+

                          .95-.98

                          Problems with urination

                          29.5

                          1.03+

                          1.02-1.05

                          1.01

                          .99-1.03

                          Vomiting

                          13.8

                          .98*

                          .97-.99

                          .97*

                          .95-.99

                          Shortness of breath

                          34.6

                          .99

                          .98-1.00

                          .99

                          .97-1.00

                          Diarrhea

                          21.8

                          1.00

                          .99-1.02

                          1.00

                          .98-1.02

                          Feeling sad

                          40.5

                          .95+

                          .94-.97

                          .96+

                          .94-.97

                          Sweats

                          37.4

                          .98**

                          .96-.99

                          .98*

                          .96-.99

                          Worrying

                          43.5

                          .95+

                          .94-.96

                          .95+

                          .94-.97

                          Problems with sexual interest

                          28.3

                          .97+

                          .95-.98

                          .95+

                          .93-.97

                          Itching

                          28.0

                          .98*

                          .97-.99

                          .99

                          .98-1.01

                          Lack of appetite

                          33.9

                          .99

                          .97-1.00

                          .99

                          .98-1.01

                          Dizziness

                          23.8

                          .99

                          .98-1.01

                          .99

                          .98-1.01

                          Difficulty swallowing

                          15.7

                          1.00

                          .98-1.02

                          1.00

                          .98-1.02

                          Feeling irritable

                          40.8

                          .96+

                          .95-.97

                          .96+

                          .95-.98

                          Mouth sores

                          13.7

                          1.00

                          .98-1.02

                          1.01

                          .99-1.03

                          Changes in the way food tastes

                          30.5

                          1.00

                          .99-1.02

                          1.01

                          .99-1.03

                          Weight loss

                          23.1

                          .99

                          .98-1.01

                          1.00

                          .98-1.02

                          Hair loss

                          20.7

                          .98*

                          .97-.99

                          .99

                          .97-1.01

                          Constipation

                          32.2

                          1.00

                          .99-1.01

                          1.00

                          .98-1.01

                          Swelling of arms or legs

                          16.4

                          1.01

                          .99-1.03

                          1.02

                          1.00-1.04

                          I don’t look like myself

                          27.3

                          .97+

                          .95-.98

                          .98*

                          .96-.99

                          Changes in skin

                          28.2

                          .96+

                          .94-.97

                          .98**

                          .96-.99

                          Abbreviation: CI, confidence interval.

                          *p < .05, **p < .01, +p < .001.

                          As shown in Table 3, after controlling for significant covariates, differences in occurrence rates between the two age groups were found for 15 (46.9%) of the 32 MSAS symptoms. Older patients reported significantly lower occurrence rates for difficulty concentrating, pain, feeling nervous, nausea, feeling drowsy, difficulty sleeping, feeling bloated, vomiting, feeling sad, sweats, worrying, problems with sexual interest, feeling irritable, I don’t look like myself, and changes in skin.
                          Table 3

                          Differences in symptom OCCURRENCE rates between younger (< 60, n = 263) and older (≥ 60, n = 330) patients

                          Symptom

                          Occurrence rates(%)by age group

                          Unadjusted values

                          Adjusted values

                          Older age

                          Older age

                          <60

                          ≥60

                          Odds ratio

                          CI

                          Odds ratio

                          CI

                          Difficulty concentrating

                          57.0

                          37.0

                          .44+

                          .32-.62

                          .58**

                          .40-.85

                          Pain

                          73.0

                          57.0

                          .49+

                          .35-.69

                          .51**

                          .34-.75

                          Lack of energy

                          81.7

                          69.1

                          .50+

                          .34-.74

                          .69

                          .44-1.08

                          Cough

                          40.3

                          35.5

                          .81

                          .58-1.14

                          .89

                          .60-1.32

                          Feeling nervous

                          39.5

                          26.7

                          .56**

                          .39-.79

                          .61*

                          .41-.91

                          Dry mouth

                          43.7

                          42.1

                          .94

                          .68-1.30

                          1.10

                          .75-1.62

                          Nausea

                          38.0

                          25.8

                          .57**

                          .40-.80

                          .52**

                          .34-.79

                          Feeling drowsy

                          65.0

                          53.6

                          .62**

                          .45-.87

                          .68*

                          .47-.99

                          Numbness/tingling in hands/feet

                          36.1

                          28.5

                          .70*

                          .50-.99

                          .76

                          .51-1.14

                          Difficulty sleeping

                          63.9

                          44.8

                          .46+

                          .33-.64

                          .55**

                          .38-.80

                          Feeling bloated

                          31.9

                          19.1

                          .50+

                          .35-.73

                          .51**

                          .33-.78

                          Problems with urination

                          21.3

                          36.1

                          2.09+

                          1.44-3.02

                          1.18

                          .76-1.83

                          Vomiting

                          17.5

                          10.9

                          .58*

                          .36-.92

                          .41**

                          .23-.72

                          Shortness of breath

                          37.6

                          32.1

                          .78

                          .56-1.10

                          .73

                          .48-1.11

                          Diarrhea

                          21.7

                          21.8

                          1.01

                          .68-1.49

                          .86

                          .54-1.35

                          Feeling sad

                          52.1

                          31.2

                          .42+

                          .30-.58

                          .46+

                          .31-.67

                          Sweats

                          45.2

                          31.2

                          .55+

                          .39-.77

                          .60**

                          .41-.88

                          Worrying

                          57.8

                          32.1

                          .35+

                          .25-.48

                          .39+

                          .27-.56

                          Problems with sexual interest

                          35.7

                          22.4

                          .52+

                          .36-.75

                          .34+

                          .22-54

                          Itching

                          34.2

                          23.0

                          .58**

                          .40-.83

                          .72

                          .47-1.08

                          Lack of appetite

                          38.0

                          30.6

                          .72

                          .51-1.01

                          .68

                          .45-1.02

                          Dizziness

                          27.0

                          21.2

                          .73

                          .50-1.06

                          .71

                          .46-1.10

                          Difficulty swallowing

                          16.3

                          15.2

                          .91

                          .59-1.43

                          .92

                          .55-1.56

                          Feeling irritable

                          51.7

                          32.1

                          .44+

                          .32-.62

                          .47+

                          .32-.69

                          Mouth sores

                          14.8

                          12.7

                          .84

                          .52-1.34

                          .91

                          .54-1.54

                          Changes in the way food tastes

                          31.2

                          30.0

                          .95

                          .67-1.34

                          1.09

                          .71-1.68

                          Weight loss

                          23.2

                          23.0

                          .99

                          .68-1.46

                          1.10

                          .69-1.73

                          Hair loss

                          23.6

                          18.5

                          .74

                          .49-1.09

                          .90

                          .55-1.49

                          Constipation

                          33.8

                          30.9

                          .87

                          .62-1.24

                          .82

                          .55-1.22

                          Swelling of arms or legs

                          16.3

                          16.4

                          1.00

                          .65-1.55

                          1.10

                          .66-1.82

                          I don’t look like myself

                          35.4

                          20.9

                          .48+

                          .34-.70

                          .64*

                          .42-.98

                          Changes in skin

                          38.0

                          20.3

                          .42+

                          .29-.60

                          .62*

                          .41-.94

                          Abbreviation: CI, confidence interval.

                          *p < .05, **p < .01, +p < .001.

                          Differences in symptom severity ratings between older and younger patients

                          As shown in Table 4, after controlling for significant covariates, differences in severity scores were found for 6 (18.9%) of the 32 MSAS symptoms. Older patients reported significantly lower severity scores for dry mouth, feeling drowsy, feeling sad, sweats, worrying, and I don’t look like myself.
                          Table 4

                          Differences in SEVERITY ratings between younger (< 60, n = 263) and older (≥ 60, n = 330) patients

                          Symptom

                          Sample size

                          Age group

                          Mean score

                          Severity ratings†(%)

                          Unadjusted values

                          Adjusted values

                          Older age

                          Older age

                          1

                          2

                          3

                          4

                          OR

                          CI

                          p-value

                          OR

                          CI

                          p-value

                          Difficulty concentrating

                          149

                          <60

                          1.67

                          44.3

                          45.0

                          10.1

                          0.7

                          .80

                          .50-1.28

                          .353

                          .78

                          .46-1.32

                          .354

                          115

                          ≥60

                          1.61

                          50.4

                          40.0

                          7.8

                          1.7

                          Pain

                          192

                          <60

                          2.08

                          24.5

                          47.9

                          22.9

                          4.7

                          1.08

                          .74-1.58

                          .674

                          .97

                          .64-1.49

                          .898

                          181

                          ≥60

                          2.12

                          24.3

                          45.3

                          24.3

                          6.1

                          Lack of energy

                          214

                          <60

                          2.15

                          15.4

                          57.5

                          23.8

                          3.3

                          .91

                          .64-1.31

                          .622

                          .81

                          .55-1.21

                          .311

                          217

                          ≥60

                          2.13

                          21.7

                          49.8

                          22.1

                          6.5

                          Cough

                          102

                          <60

                          1.74

                          46.1

                          36.3

                          15.7

                          2.0

                          1.04

                          .63-1.73

                          .870

                          .86

                          .47-1.55

                          .609

                          110

                          ≥60

                          1.75

                          44.5

                          38.2

                          14.5

                          2.7

                          Feeling nervous

                          103

                          <60

                          1.83

                          35.9

                          47.6

                          13.6

                          2.9

                          .81

                          .47-1.40

                          .452

                          .81

                          .42-1.54

                          .514

                          85

                          ≥60

                          1.78

                          40.0

                          48.2

                          5.9

                          5.9

                          Dry mouth

                          110

                          <60

                          2.06

                          28.2

                          41.8

                          25.5

                          4.5

                          .64

                          .40-1.03

                          .068

                          .54

                          .32-.91

                          .020

                          131

                          ≥60

                          1.89

                          38.2

                          41.2

                          14.5

                          6.1

                          Nausea

                          99

                          <60

                          1.99

                          31.3

                          42.4

                          22.2

                          4.0

                          .64

                          .37-1.10

                          .107

                          .62

                          .33-1.14

                          .123

                          81

                          ≥60

                          1.80

                          43.2

                          37.0

                          16.0

                          3.7

                          Feeling drowsy

                          167

                          <60

                          1.95

                          24.6

                          58.1

                          15.6

                          1.8

                          .68

                          .45-1.03

                          .068

                          .61

                          .38-.96

                          .033

                          169

                          ≥60

                          1.82

                          32.5

                          55.0

                          10.7

                          1.8

                          Numbness/tingling in hands/feet

                          94

                          <60

                          1.85

                          36.2

                          45.7

                          14.9

                          3.2

                          .90

                          .53-1.55

                          .710

                          .79

                          .42-1.52

                          .484

                          91

                          ≥60

                          1.85

                          41.8

                          38.5

                          13.2

                          6.6

                          Difficulty sleeping

                          168

                          <60

                          2.23

                          14.9

                          54.8

                          23.2

                          7.1

                          .87

                          .56-1.33

                          .512

                          .67

                          .42-1.09

                          .108

                          141

                          ≥60

                          2.16

                          17.0

                          54.6

                          24.1

                          4.3

                          Feeling bloated

                          82

                          <60

                          1.91

                          30.5

                          51.2

                          14.6

                          3.7

                          .77

                          .40-1.47

                          .429

                          .77

                          .36-1.66

                          .510

                          55

                          ≥60

                          1.82

                          36.4

                          49.1

                          10.9

                          3.6

                          Problems with urination

                          54

                          <60

                          1.96

                          33.3

                          42.6

                          18.5

                          5.6

                          1.14

                          .61-2.11

                          .685

                          1.10

                          .56-2.18

                          .777

                          110

                          ≥60

                          2.01

                          26.4

                          52.7

                          14.5

                          6.4

                          Vomiting

                          43

                          <60

                          1.91

                          41.9

                          32.6

                          18.6

                          7.0

                          .90

                          .38-2.14

                          .811

                          .51

                          .17-1.54

                          .232

                          29

                          ≥60

                          1.79

                          37.9

                          44.8

                          17.2

                          0.0

                          Shortness of breath

                          97

                          <60

                          1.78

                          40.2

                          45.4

                          10.3

                          4.1

                          1.52

                          .90-2.58

                          .116

                          1.27

                          .71-2.29

                          .423

                          99

                          ≥60

                          2.00

                          33.3

                          42.4

                          15.2

                          9.1

                          Diarrhea

                          54

                          <60

                          1.93

                          24.1

                          61.1

                          13.0

                          1.9

                          .67

                          .33-1.35

                          .263

                          .62

                          .27-1.42

                          .258

                          63

                          ≥60

                          1.81

                          36.5

                          49.2

                          11.1

                          3.2

                          Feeling sad

                          137

                          <60

                          1.99

                          30.7

                          43.8

                          21.2

                          4.4

                          .43

                          .26-.72

                          .001

                          .43

                          .24-.76

                          .003

                          93

                          ≥60

                          1.66

                          46.2

                          46.2

                          3.2

                          4.3

                          Sweats

                          117

                          <60

                          2.14

                          23.9

                          44.4

                          25.6

                          6.0

                          .54

                          .33-.91

                          .019

                          .56

                          .31-.997

                          .049

                          95

                          ≥60

                          1.86

                          34.7

                          46.3

                          16.8

                          2.1

                          Worrying

                          152

                          <60

                          2.10

                          20.4

                          58.6

                          11.8

                          9.2

                          .43

                          .26-.72

                          .001

                          .52

                          .30-.90

                          .020

                          101

                          ≥60

                          1.77

                          38.6

                          49.5

                          7.9

                          4.0

                          Problems with sexual interest

                          92

                          <60

                          2.50

                          22.8

                          31.5

                          18.5

                          27.2

                          1.43

                          .82-2.52

                          .212

                          1.12

                          .57-2.19

                          .745

                          69

                          ≥60

                          2.72

                          18.8

                          24.6

                          21.7

                          34.8

                          Itching

                          88

                          <60

                          1.86

                          38.6

                          43.2

                          11.4

                          6.8

                          .84

                          .46-1.52

                          .562

                          .89

                          .46-1.75

                          .745

                          69

                          ≥60

                          1.78

                          42.0

                          43.5

                          8.7

                          5.8

                          Lack of appetite

                          99

                          <60

                          2.00

                          27.3

                          49.5

                          19.2

                          4.0

                          .96

                          .57-1.64

                          .886

                          .77

                          .42-1.43

                          .409

                          94

                          ≥60

                          2.00

                          27.7

                          51.1

                          14.9

                          6.4

                          Dizziness

                          69

                          <60

                          1.54

                          55.1

                          37.7

                          5.8

                          1.4

                          .84

                          .43-1.65

                          .615

                          .61

                          .27-1.39

                          .241

                          64

                          ≥60

                          1.48

                          59.4

                          34.4

                          4.7

                          1.6

                          Difficulty swallowing

                          40

                          <60

                          2.03

                          27.5

                          45.0

                          25.0

                          2.5

                          .53

                          .23-1.21

                          .133

                          .39

                          .14-1.10

                          .074

                          43

                          ≥60

                          1.79

                          37.2

                          51.2

                          7.0

                          4.7

                          Feeling irritable

                          135

                          <60

                          1.77

                          40.7

                          42.2

                          16.3

                          0.7

                          .82

                          .50-1.34

                          .425

                          .65

                          .37-1.15

                          .142

                          98

                          ≥60

                          1.68

                          41.8

                          49.0

                          8.2

                          1.0

                          Mouth sores

                          37

                          <60

                          1.86

                          43.2

                          35.1

                          13.5

                          8.1

                          .55

                          .23-1.34

                          .188

                          .52

                          .19-1.43

                          .205

                          35

                          ≥60

                          1.60

                          60.0

                          22.9

                          14.3

                          2.9

                          Change in way food tastes

                          79

                          <60

                          2.06

                          27.8

                          48.1

                          13.9

                          10.1

                          .81

                          .46-1.43

                          .476

                          1.05

                          .57-1.93

                          .883

                          91

                          ≥60

                          1.96

                          31.9

                          47.3

                          14.3

                          6.6

                          Weight loss

                          60

                          <60

                          1.67

                          48.3

                          38.3

                          11.7

                          1.7

                          .87

                          .45-1.69

                          .674

                          .60

                          .28-1.30

                          .196

                          67

                          ≥60

                          1.63

                          52.2

                          35.8

                          9.0

                          3.0

                          Hair loss

                          61

                          <60

                          2.38

                          27.9

                          26.2

                          26.2

                          19.7

                          .97

                          .50-1.88

                          .921

                          .77

                          .36-1.61

                          .482

                          52

                          ≥60

                          2.37

                          32.7

                          23.1

                          19.2

                          25.0

                          Constipation

                          87

                          <60

                          2.38

                          17.2

                          40.2

                          29.9

                          12.6

                          .67

                          .39-1.14

                          .139

                          .74

                          .42-1.32

                          .308

                          96

                          ≥60

                          2.19

                          24.0

                          43.8

                          21.9

                          10.4

                          Swelling of arms or legs

                          42

                          <60

                          2.19

                          33.3

                          31.0

                          19.0

                          16.7

                          .92

                          .43-1.98

                          .837

                          .86

                          .36-2.04

                          .734

                          47

                          ≥60

                          2.09

                          25.5

                          44.7

                          25.5

                          4.3

                          I don’t look like myself

                          91

                          <60

                          2.14

                          24.2

                          47.3

                          18.7

                          9.9

                          .52

                          .28-.95

                          .033

                          .49

                          .25-.96

                          .037

                          62

                          ≥60

                          1.82

                          43.5

                          32.3

                          22.6

                          1.6

                          Changes in skin

                          99

                          <60

                          2.07

                          24.2

                          53.5

                          13.1

                          9.1

                          .63

                          .34-1.16

                          .140

                          .80

                          .41-1.56

                          .510

                          61

                          ≥60

                          1.89

                          37.7

                          42.6

                          13.1

                          6.6

                          Abbreviations: CI, confidence interval; OR, odds ratio.

                          †Severity ratings = slight (1), moderate (2), severe (3), very severe (4).

                          Differences in symptom frequency ratings between older and younger patients

                          As shown in Table 5, after controlling for significant covariates, differences in frequency scores were found for 4 (12.5%) of the 32 MSAS symptoms. Older patients reported significantly lower frequency scores for feeling nervous, dry mouth, nausea, and feeling bloated.
                          Table 5

                          Differences in FREQUENCY ratings between younger (< 60, n = 263) and older (≥ 60, n = 330) patients

                          Symptom

                          Sample size

                          Age group

                          Mean score

                          Frequency ratings† (%)

                          Unadjusted values

                          Adjusted values

                          Older age

                          Older age

                          1

                          2

                          3

                          4

                          OR

                          CI

                          p-value

                          OR

                          CI

                          p-value

                          Difficulty concentrating

                          150

                          <60

                          2.19

                          22.7

                          44.0

                          25.3

                          8.0

                          .78

                          .50-1.21

                          .269

                          .76

                          .46-1.25

                          .277

                          122

                          ≥60

                          2.08

                          24.6

                          50.8

                          16.4

                          8.2

                          Pain

                          192

                          <60

                          2.64

                          13.0

                          33.3

                          30.2

                          23.4

                          .96

                          .67-1.38

                          .829

                          .95

                          .63-1.44

                          .825

                          188

                          ≥60

                          2.62

                          14.9

                          32.4

                          28.7

                          23.9

                          Lack of energy

                          215

                          <60

                          2.82

                          5.1

                          30.2

                          42.3

                          22.3

                          .88

                          .62-1.23

                          .446

                          .77

                          .53-1.13

                          .179

                          228

                          ≥60

                          2.74

                          10.5

                          32.0

                          30.3

                          27.2

                          Cough

                          106

                          <60

                          2.12

                          26.4

                          41.5

                          25.5

                          6.6

                          .98

                          .61-1.59

                          .937

                          .72

                          .42-1.25

                          .246

                          117

                          ≥60

                          2.12

                          26.5

                          42.7

                          23.1

                          7.7

                          Feeling nervous

                          104

                          <60

                          2.13

                          22.1

                          48.1

                          24.0

                          5.8

                          .57

                          .33-.97

                          .038

                          .52

                          .27-.99

                          .046

                          88

                          ≥60

                          1.92

                          35.2

                          45.5

                          11.4

                          8.0

                          Dry mouth

                          115

                          <60

                          2.66

                          13.9

                          26.1

                          40.0

                          20.0

                          .66

                          .42-1.03

                          .070

                          .52

                          .32-.85

                          .009

                          139

                          ≥60

                          2.44

                          20.9

                          31.7

                          30.2

                          17.3

                          Nausea

                          100

                          <60

                          2.23

                          23.0

                          40.0

                          28.0

                          9.0

                          .55

                          .32-.94

                          .028

                          .54

                          .29-.99

                          .047

                          85

                          ≥60

                          1.95

                          34.1

                          43.5

                          15.3

                          7.1

                          Feeling drowsy

                          171

                          <60

                          2.40

                          11.7

                          44.4

                          36.3

                          7.6

                          .82

                          .56-1.22

                          .338

                          .65

                          .42-1.01

                          .058

                          176

                          ≥60

                          2.34

                          11.9

                          52.3

                          25.6

                          10.2

                          Numbness/tingling in hands/feet

                          95

                          <60

                          2.63

                          16.8

                          36.8

                          12.6

                          33.7

                          1.08

                          .65-1.81

                          .771

                          .94

                          .52-1.72

                          .846

                          94

                          ≥60

                          2.68

                          20.2

                          23.4

                          24.5

                          31.9

                          Difficulty sleeping

                          168

                          <60

                          2.70

                          9.5

                          32.1

                          37.5

                          20.8

                          .88

                          .59-1.32

                          .541

                          .64

                          .41-1.02

                          .058

                          147

                          ≥60

                          2.63

                          9.5

                          32.7

                          42.9

                          15.0

                          Feeling bloated

                          84

                          <60

                          2.39

                          22.6

                          32.1

                          28.6

                          16.7

                          .54

                          .29-.98

                          .042

                          .49

                          .24-.99

                          .046

                          63

                          ≥60

                          2.06

                          28.6

                          47.6

                          12.7

                          11.1

                          Problems with urination

                          56

                          <60

                          2.39

                          21.4

                          33.9

                          28.6

                          16.1

                          1.52

                          .84-2.73

                          .164

                          1.29

                          .68-2.46

                          .438

                          119

                          ≥60

                          2.61

                          11.8

                          33.6

                          37.0

                          17.6

                          Vomiting

                          46

                          <60

                          1.87

                          39.1

                          41.3

                          13.0

                          6.5

                          .85

                          .38-1.93

                          .705

                          .46

                          .15-1.38

                          .165

                          36

                          ≥60

                          1.81

                          44.4

                          36.1

                          13.9

                          5.6

                          Shortness of breath

                          99

                          <60

                          2.17

                          19.2

                          52.5

                          20.2

                          8.1

                          1.30

                          .78-2.14

                          .311

                          .97

                          .55-1.70

                          .916

                          106

                          ≥60

                          2.35

                          25.5

                          34.0

                          20.8

                          19.8

                          Diarrhea

                          57

                          <60

                          2.12

                          22.8

                          47.4

                          24.6

                          5.3

                          .56

                          .29-1.10

                          .094

                          .47

                          .21-1.03

                          .059

                          72

                          ≥60

                          1.89

                          29.2

                          55.6

                          12.5

                          2.8

                          Feeling sad

                          137

                          <60

                          2.05

                          28.5

                          42.3

                          24.8

                          4.4

                          .99

                          .62-1.59

                          .978

                          .79

                          .46-1.36

                          .386

                          103

                          ≥60

                          2.08

                          27.2

                          47.6

                          15.5

                          9.7

                          Sweats

                          119

                          <60

                          2.39

                          16.8

                          37.0

                          36.1

                          10.1

                          .66

                          .41-1.07

                          .093

                          .64

                          .37-1.12

                          .121

                          103

                          ≥60

                          2.21

                          22.3

                          44.7

                          22.3

                          10.7

                          Worrying

                          152

                          <60

                          2.41

                          9.9

                          52.0

                          25.0

                          13.2

                          .59

                          .36-.94

                          .028

                          .63

                          .37-1.08

                          .094

                          106

                          ≥60

                          2.20

                          22.6

                          48.1

                          16.0

                          13.2

                          Problems with sexual interest

                          93

                          <60

                          2.86

                          15.1

                          23.7

                          21.5

                          39.8

                          1.07

                          .61-1.86

                          .821

                          1.04

                          .53-2.02

                          .916

                          74

                          ≥60

                          2.89

                          17.6

                          17.6

                          23.0

                          41.9

                          Itching

                          90

                          <60

                          2.38

                          14.4

                          46.7

                          25.6

                          13.3

                          .72

                          .41-1.27

                          .254

                          .71

                          .38-1.33

                          .289

                          76

                          ≥60

                          2.21

                          23.7

                          40.8

                          26.3

                          9.2

                          Lack of appetite

                          100

                          <60

                          2.44

                          18.0

                          39.0

                          24.0

                          19.0

                          1.44

                          .88-2.38

                          .149

                          1.16

                          .66-2.05

                          .598

                          101

                          ≥60

                          2.64

                          18.8

                          24.8

                          29.7

                          26.7

                          Dizziness

                          71

                          <60

                          1.82

                          39.4

                          40.8

                          18.3

                          1.4

                          .96

                          .52-1.78

                          .902

                          .78

                          .38-1.61

                          .502

                          70

                          ≥60

                          1.81

                          38.6

                          45.7

                          11.4

                          4.3

                          Difficulty swallowing

                          43

                          <60

                          2.23

                          30.2

                          32.6

                          20.9

                          16.3

                          .87

                          .41-1.81

                          .701

                          .56

                          .23-1.38

                          .207

                          50

                          ≥60

                          2.14

                          32.0

                          34.0

                          22.0

                          12.0

                          Feeling irritable

                          136

                          <60

                          1.99

                          30.1

                          44.1

                          22.1

                          3.7

                          .78

                          .48-1.25

                          .300

                          .67

                          .38-1.17

                          .161

                          105

                          ≥60

                          1.88

                          33.3

                          47.6

                          17.1

                          1.9

                          Mouth sores

                          39

                          <60

                          2.21

                          38.5

                          28.2

                          7.7

                          25.6

                          .73

                          .33-1.63

                          .447

                          .75

                          .29-1.93

                          .553

                          42

                          ≥60

                          2.02

                          47.6

                          23.8

                          7.1

                          21.4

                          Change in way food tastes

                          80

                          <60

                          2.54

                          17.5

                          31.3

                          31.3

                          20.0

                          1.11

                          .65-1.88

                          .709

                          1.16

                          .65-2.08

                          .616

                          98

                          ≥60

                          2.60

                          16.3

                          33.7

                          23.5

                          26.5

                          Weight loss

                          59

                          <60

                          2.07

                          22.0

                          55.9

                          15.3

                          6.8

                          .76

                          .40-1.44

                          .400

                          .56

                          .27-1.16

                          .120

                          75

                          ≥60

                          1.99

                          34.7

                          41.3

                          14.7

                          9.3

                          Hair loss

                          62

                          <60

                          2.85

                          16.1

                          22.6

                          21.0

                          40.3

                          1.02

                          .53-1.95

                          .953

                          .89

                          .43-1.84

                          .745

                          60

                          ≥60

                          2.85

                          21.7

                          15.0

                          20.0

                          43.3

                          Constipation

                          89

                          <60

                          2.53

                          14.6

                          40.4

                          22.5

                          22.5

                          .82

                          .49-1.38

                          .455

                          .87

                          .49-1.53

                          .626

                          102

                          ≥60

                          2.42

                          15.7

                          45.1

                          20.6

                          18.6

                          Swelling of arms or legs

                          43

                          <60

                          2.67

                          23.3

                          23.3

                          16.3

                          37.2

                          1.04

                          .51-2.15

                          .906

                          .91

                          .39-2.12

                          .832

                          54

                          ≥60

                          2.70

                          24.1

                          20.4

                          16.7

                          38.9

                          I don’t look like myself

                          92

                          <60

                          2.67

                          15.2

                          29.3

                          28.3

                          27.2

                          .79

                          .45-1.39

                          .420

                          .84

                          .45-1.57

                          .587

                          69

                          ≥60

                          2.54

                          20.3

                          27.5

                          30.4

                          21.7

                          Changes in skin

                          100

                          <60

                          2.77

                          15.0

                          24.0

                          30.0

                          31.0

                          .69

                          .39-1.20

                          .188

                          .97

                          .52-1.82

                          .929

                          67

                          ≥60

                          2.54

                          23.9

                          25.4

                          23.9

                          26.9

                          Abbreviations: CI, confidence interval; OR, odds ratio.

                          †Frequency ratings = rarely (1), occasionally (2), frequently (3), almost constantly (4).

                          Differences in symptom distress ratings between older and younger patients

                          As shown in Table 6, after controlling for significant covariates, differences in distress scores were found for 14 (43.8%) of the 32 MSAS symptoms. Older patients reported significantly lower distress scores for pain, lack of energy, cough, dry mouth, nausea, feeling drowsy, difficulty sleeping, feeling bloated, feeling sad, sweats, worrying, hair loss, I don’t look like myself, and changes in skin.
                          Table 6

                          Differences in DISTRESS ratings between younger (< 60, n = 263) and older (≥ 60, n = 330) patients

                          Symptom

                          Sample size

                          Age group

                          Mean score

                          Distress ratings†(%)

                          Unadjusted values

                          Adjusted values

                          Older age

                          Older age

                          0

                          1

                          2

                          3

                          4

                          OR

                          CI

                          p-value

                          OR

                          CI

                          p-value

                          Difficulty concentrating

                          147

                          <60

                          1.52

                          17.7

                          38.1

                          22.4

                          18.4

                          3.4

                          .71

                          .45-1.10

                          .124

                          .82

                          .50-1.34

                          .424

                          116

                          ≥60

                          1.33

                          25.0

                          37.9

                          21.6

                          10.3

                          5.2

                          Pain

                          192

                          <60

                          2.01

                          6.3

                          32.3

                          29.2

                          19.3

                          13.0

                          .63

                          .43-.90

                          .012

                          .65

                          .43-.98

                          .041

                          183

                          ≥60

                          1.69

                          15.8

                          32.2

                          26.2

                          18.0

                          7.7

                          Lack of energy

                          212

                          <60

                          2.04

                          8.5

                          26.4

                          30.2

                          22.6

                          12.3

                          .54

                          .39-.77

                          <.001

                          .57

                          .39-.83

                          .004

                          220

                          ≥60

                          1.64

                          20.5

                          30.5

                          22.3

                          18.6

                          8.2

                          Cough

                          103

                          <60

                          1.39

                          29.1

                          28.2

                          24.3

                          11.7

                          6.8

                          .60

                          .37-.97

                          .037

                          .52

                          .29-.91

                          .022

                          112

                          ≥60

                          1.07

                          42.9

                          25.0

                          19.6

                          7.1

                          5.4

                          Feeling nervous

                          102

                          <60

                          1.70

                          10.8

                          38.2

                          26.5

                          19.6

                          4.9

                          .51

                          .30-.87

                          .013

                          .57

                          .30-1.06

                          .075

                          85

                          ≥60

                          1.33

                          23.5

                          40.0

                          22.4

                          8.2

                          5.9

                          Dry mouth

                          111

                          <60

                          1.45

                          22.5

                          37.8

                          20.7

                          9.9

                          9.0

                          .50

                          .32-.80

                          .003

                          .47

                          .29-.76

                          .002

                          133

                          ≥60

                          1.05

                          42.1

                          29.3

                          15.8

                          7.5

                          5.3

                          Nausea

                          99

                          <60

                          1.84

                          12.1

                          32.3

                          29.3

                          12.1

                          14.1

                          .47

                          .27-.80

                          .006

                          .46

                          .25-.86

                          .015

                          81

                          ≥60

                          1.37

                          33.3

                          29.6

                          13.6

                          13.6

                          9.9

                          Feeling drowsy

                          165

                          <60

                          1.39

                          21.2

                          39.4

                          23.0

                          12.1

                          4.2

                          .53

                          .36-.79

                          .002

                          .52

                          .34-.80

                          .003

                          167

                          ≥60

                          1.07

                          40.1

                          31.7

                          13.8

                          9.6

                          4.8

                          Numbness/tingling in hands/feet

                          94

                          <60

                          1.40

                          21.3

                          39.4

                          20.2

                          16.0

                          3.2

                          .72

                          .43-1.21

                          .212

                          .84

                          .46-1.56

                          .586

                          91

                          ≥60

                          1.25

                          33.0

                          33.0

                          16.5

                          11.0

                          6.6

                          Difficulty sleeping

                          166

                          <60

                          2.01

                          9.6

                          29.5

                          25.9

                          19.9

                          15.1

                          .61

                          .41-.92

                          .017

                          .54

                          .35-.86

                          .008

                          142

                          ≥60

                          1.66

                          19.0

                          27.5

                          29.6

                          16.2

                          7.7

                          Feeling bloated

                          81

                          <60

                          1.85

                          16.0

                          24.7

                          27.2

                          22.2

                          9.9

                          .43

                          .23-.81

                          .008

                          .38

                          .18-.80

                          .011

                          56

                          ≥60

                          1.30

                          19.6

                          42.9

                          26.8

                          8.9

                          1.8

                          Problems with urination

                          54

                          <60

                          1.57

                          24.1

                          25.9

                          25.9

                          16.7

                          7.4

                          1.21

                          .67-2.19

                          .530

                          .91

                          .47-1.76

                          .783

                          108

                          ≥60

                          1.70

                          14.8

                          32.4

                          31.5

                          10.2

                          11.1

                          Vomiting

                          43

                          <60

                          1.63

                          23.3

                          32.6

                          16.3

                          14.0

                          14.0

                          .78

                          .34-1.79

                          .553

                          .58

                          .21-1.62

                          .298

                          30

                          ≥60

                          1.43

                          33.3

                          20.0

                          26.7

                          10.0

                          10.0

                          Shortness of breath

                          97

                          <60

                          1.63

                          14.4

                          41.2

                          21.6

                          12.4

                          10.3

                          .79

                          .48-1.30

                          .347

                          .80

                          .46-1.39

                          .427

                          100

                          ≥60

                          1.47

                          28.0

                          26.0

                          24.0

                          15.0

                          7.0

                          Diarrhea

                          54

                          <60

                          1.59

                          18.5

                          38.9

                          14.8

                          20.4

                          7.4

                          .69

                          .36-1.34

                          .274

                          .61

                          .28-1.31

                          .204

                          63

                          ≥60

                          1.32

                          25.4

                          33.3

                          30.2

                          6.3

                          4.8

                          Feeling sad

                          137

                          <60

                          1.87

                          8.0

                          36.5

                          27.0

                          17.5

                          10.9

                          .47

                          .29-.77

                          .003

                          .49

                          .28-.85

                          .011

                          94

                          ≥60

                          1.41

                          14.9

                          46.8

                          24.5

                          9.6

                          4.3

                          Sweats

                          117

                          <60

                          1.75

                          17.1

                          29.1

                          28.2

                          12.8

                          12.8

                          .49

                          .30-.80

                          .005

                          .56

                          .32-.98

                          .040

                          95

                          ≥60

                          1.26

                          24.2

                          40.0

                          24.2

                          8.4

                          3.2

                          Worrying

                          151

                          <60

                          1.93

                          7.3

                          34.4

                          28.5

                          17.9

                          11.9

                          .45

                          .28-.72

                          .001

                          .57

                          .34-.96

                          .033

                          101

                          ≥60

                          1.46

                          8.9

                          53.5

                          23.8

                          10.9

                          3.0

                          Problems with sexual interest

                          91

                          <60

                          2.08

                          22.0

                          19.8

                          15.4

                          14.3

                          28.6

                          .96

                          .55-1.66

                          .875

                          .89

                          .46-1.73

                          .731

                          69

                          ≥60

                          2.03

                          18.8

                          20.3

                          24.6

                          11.6

                          24.6

                          Itching

                          88

                          <60

                          1.56

                          15.9

                          40.9

                          25.0

                          8.0

                          10.2

                          .82

                          .46-1.45

                          .497

                          1.04

                          .55-1.95

                          .908

                          69

                          ≥60

                          1.42

                          24.6

                          31.9

                          27.5

                          8.7

                          7.2

                          Lack of appetite

                          99

                          <60

                          1.38

                          27.3

                          31.3

                          24.2

                          10.1

                          7.1

                          .85

                          .51-1.41

                          .529

                          .85

                          .48-1.51

                          .589

                          96

                          ≥60

                          1.28

                          32.3

                          29.2

                          21.9

                          11.5

                          5.2

                          Dizziness

                          69

                          <60

                          1.32

                          23.2

                          37.7

                          26.1

                          10.1

                          2.9

                          .84

                          .45-1.56

                          .572

                          .62

                          .30-1.29

                          .202

                          63

                          ≥60

                          1.25

                          23.8

                          46.0

                          15.9

                          9.5

                          4.8

                          Difficulty swallowing

                          40

                          <60

                          1.65

                          10.0

                          40.0

                          30.0

                          15.0

                          5.0

                          .96

                          .44-2.09

                          .924

                          .85

                          .35-2.06

                          .724

                          43

                          ≥60

                          1.63

                          20.9

                          27.9

                          23.3

                          23.3

                          4.7

                          Feeling irritable

                          135

                          <60

                          1.49

                          21.5

                          34.8

                          24.4

                          11.9

                          7.4

                          .79

                          .49-1.27

                          .335

                          .82

                          .48-1.42

                          .485

                          96

                          ≥60

                          1.31

                          18.8

                          47.9

                          17.7

                          14.6

                          1.0

                          Mouth sores

                          36

                          <60

                          1.67

                          22.2

                          30.6

                          19.4

                          13.9

                          13.9

                          .46

                          .20-1.09

                          .079

                          .41

                          .16-1.03

                          .058

                          35

                          ≥60

                          1.11

                          31.4

                          42.9

                          11.4

                          11.4

                          2.9

                          Change in way food tastes

                          78

                          <60

                          1.69

                          17.9

                          32.1

                          25.6

                          11.5

                          12.8

                          .47

                          .27-.81

                          .007

                          .57

                          .31-1.05

                          .072

                          89

                          ≥60

                          1.18

                          32.6

                          36.0

                          14.6

                          14.6

                          2.2

                          Weight loss

                          61

                          <60

                          1.05

                          45.9

                          26.2

                          13.1

                          6.6

                          8.2

                          .67

                          .35-1.29

                          .232

                          .51

                          .24-1.09

                          .082

                          68

                          ≥60

                          0.78

                          54.4

                          26.5

                          8.8

                          7.4

                          2.9

                          Hair loss

                          61

                          <60

                          1.74

                          19.7

                          29.5

                          21.3

                          16.4

                          13.1

                          .50

                          .26-.97

                          .041

                          .48

                          .23-.99

                          .048

                          55

                          ≥60

                          1.29

                          43.6

                          20.0

                          9.1

                          18.2

                          9.1

                          Constipation

                          87

                          <60

                          2.09

                          13.8

                          23.0

                          25.3

                          16.1

                          21.8

                          .68

                          .41-1.14

                          .145

                          .74

                          .42-1.29

                          .285

                          95

                          ≥60

                          1.80

                          23.2

                          25.3

                          15.8

                          20.0

                          15.8

                          Swelling of arms or legs

                          42

                          <60

                          1.64

                          28.6

                          23.8

                          19.0

                          11.9

                          16.7

                          .96

                          .46-2.01

                          .913

                          1.11

                          .46-2.67

                          .819

                          48

                          ≥60

                          1.58

                          27.1

                          25.0

                          18.8

                          20.8

                          8.3

                          I don’t look like myself

                          91

                          <60

                          1.89

                          11.0

                          36.3

                          19.8

                          18.7

                          14.3

                          .32

                          .17-.58

                          <.001

                          .30

                          .15-.58

                          <.001

                          64

                          ≥60

                          1.14

                          34.4

                          34.4

                          17.2

                          10.9

                          3.1

                          Changes in skin

                          99

                          <60

                          1.76

                          11.1

                          36.4

                          29.3

                          12.1

                          11.1

                          .41

                          .23-.76

                          .004

                          .51

                          .27-.98

                          .043

                          62

                          ≥60

                          1.26

                          38.7

                          24.2

                          17.7

                          11.3

                          8.1

                          Abbreviations: CI, confidence interval; OR, odds ratio.

                          †Distress ratings = not at all (0), a little bit (1), somewhat (2), quite a bit (4), very much (5).

                          Differences in MSAS subscale and total scores between younger and older patients

                          As shown in Table 7, after controlling for significant covariates, older patients reported significantly lower scores on all of the MSAS subscales, as well as on the MSAS total score.
                          Table 7

                          Differences in subscale and total scores on the Memorial Symptom Assessment Scale (MSAS) between younger (< 60, n = 263) and older (≥ 60, n = 330) patients

                          Scale

                          Unadjusted scores

                          Adjusted scores

                          Mean(Standard deviation)

                          Mean(Standard error)

                          < 60 years

                          ≥ 60 years

                          p-value

                          < 60 years

                          ≥ 60 years

                          p-value

                          Physical subscale

                          .92 (.63)

                          .70 (.58)

                          <.0001

                          .90 (.04)

                          .70 (.03)

                          <.0001

                          Psychological subscale

                          1.15 (.84)

                          .67 (.69)

                          <.0001

                          1.10 (.05)

                          .70 (.04)

                          <.0001

                          Global Distress Index

                          1.17 (.74)

                          .78 (.70)

                          <.0001

                          1.13 (.04)

                          .81 (.04)

                          <.0001

                          Total MSAS score

                          .84 (.50)

                          .60 (.46)

                          <.0001

                          .81 (.03)

                          .60 (.03)

                          <.0001

                          Differences in rankings of symptoms with highest occurrence, severity, frequency, and distress ratings between older and younger patients

                          Table 8 provides a summary of the differences in the rankings of the various symptom dimensions (i.e., occurrence, severity, frequency, distress) for the top 10 symptoms between older and younger patients. For symptom occurrence, the four most prevalent symptoms (i.e., lack of energy, pain, feeling drowsy, difficulty sleeping) were the same for both age groups. Eight of 10 symptoms (80%) were in the top 10 for both age groups. Feeling sad and sweats were unique to younger patients. Problems with urination, cough, and shortness of breath were unique to older patients.
                          Table 8

                          Differences between younger (< 60, n = 263) and older (≥ 60, n = 330) patients in rankings of symptoms with the highest occurrence, severity, frequency, and distress ratings

                            

                          OCCURRENCE RATINGS

                          Rank

                           

                          < 60

                          ≥ 60

                          Symptom

                          % of patients

                          Symptom

                          % of patients

                           

                          1

                          Lack of energy

                          81.7

                          Lack of energy

                          69.1

                           

                          2

                          Pain

                          73.0

                          Pain

                          57.0

                           

                          3

                          Feeling drowsy

                          65.0

                          Feeling drowsy

                          53.6

                           

                          4

                          Difficulty sleeping

                          63.9

                          Difficulty sleeping

                          44.8

                           

                          5

                          Worrying

                          57.8

                          Dry mouth

                          42.1

                           

                          6

                          Difficulty concentrating

                          57.0

                          Difficulty concentrating

                          37.0

                           

                          7

                          Feeling sad

                          52.1

                          Problems with urination

                          36.1

                           

                          8

                          Feeling irritable

                          51.7

                          Cough

                          35.5

                           

                          9

                          Sweats

                          45.2

                          Shortness of breath

                          32.1

                           

                          10

                          Dry mouth

                          43.7

                          Worrying

                          32.1

                           
                             

                          Feeling irritable

                          32.1

                           

                          SEVERITY RATINGS

                           

                          Rank

                          Symptom

                          Mean score

                          Symptom

                          Mean score

                           

                          1

                          Problems with sexual interest

                          2.50

                          Problems with sexual interest

                          2.72

                           

                          2

                          Hair loss

                          2.38

                          Hair loss

                          2.37

                           

                          3

                          Constipation

                          2.38

                          Constipation

                          2.19

                           

                          4

                          Difficulty sleeping

                          2.23

                          Difficulty sleeping

                          2.16

                           

                          5

                          Swelling of arms or legs

                          2.19

                          Lack of energy

                          2.13

                           

                          6

                          Lack of energy

                          2.15

                          Pain

                          2.12

                           

                          7

                          Sweats

                          2.14

                          Swelling of arms or legs

                          2.09

                           

                          8

                          I don’t look like myself

                          2.14

                          Problems with urination

                          2.01

                           

                          9

                          Worrying

                          2.10

                          Shortness of breath

                          2.00

                           

                          10

                          Pain

                          2.08

                          Lack of appetite

                          2.00

                           

                          FREQUENCY RATINGS

                           

                          Rank

                          Symptom

                          Mean score

                          Symptom

                          Mean score

                           

                          1

                          Problems with sexual interest

                          2.86

                          Problems with sexual interest

                          2.89

                           

                          2

                          Hair loss

                          2.85

                          Hair loss

                          2.85

                           

                          3

                          Lack of energy

                          2.82

                          Lack of energy

                          2.74

                           

                          4

                          Changes in skin

                          2.77

                          Swelling of arms or legs

                          2.70

                           

                          5

                          Difficulty sleeping

                          2.70

                          Numbness/tingling in hands/feet

                          2.68

                           

                          6

                          Swelling of arms or legs

                          2.67

                          Lack of appetite

                          2.64

                           

                          7

                          I don’t look like myself

                          2.67

                          Difficulty sleeping

                          2.63

                           

                          8

                          Dry mouth

                          2.66

                          Pain

                          2.62

                           

                          9

                          Pain

                          2.64

                          Problems with urination

                          2.61

                           

                          10

                          Numbness/tingling in hands/feet

                          2.63

                          Changes in taste

                          2.60

                           

                          DISTRESS RATINGS

                           

                          Rank

                          Symptom

                          Mean score

                          Symptom

                          Mean score

                           

                          1

                          Constipation

                          2.09

                          Problems with sexual interest

                          2.03

                           

                          2

                          Problems with sexual interest

                          2.08

                          Constipation

                          1.80

                           

                          3

                          Lack of energy

                          2.04

                          Problems with urination

                          1.70

                           

                          4

                          Pain

                          2.01

                          Pain

                          1.69

                           

                          5

                          Difficulty sleeping

                          2.01

                          Difficulty sleeping

                          1.66

                           

                          6

                          Worrying

                          1.93

                          Lack of energy

                          1.64

                           

                          7

                          I don’t look like myself

                          1.89

                          Difficulty swallowing

                          1.63

                           

                          8

                          Feeling sad

                          1.87

                          Swelling of arms or legs

                          1.58

                           

                          9

                          Feeling bloated

                          1.85

                          Shortness of breath

                          1.47

                           

                          10

                          Nausea

                          1.84

                          Worrying

                          1.46

                           

                          For symptom severity, the four most severe symptoms (i.e., problems with sexual interest, hair loss, constipation, difficulty sleeping) were the same for both age groups. Seven of 10 symptoms (70%) were in the top 10 for both age groups. Sweats, I don’t look like myself, and worrying were unique to younger patients. Problems with urination, shortness of breath, and lack of appetite were unique to older patients.

                          For symptom frequency, the three most frequent symptoms (i.e., problems with sexual interest, hair loss, lack of energy) were the same for both age groups. Seven of 10 symptoms (70%) were in the top 10 for both age groups. Dry mouth, I don’t look like myself, and changes in skin were unique to younger patients. Problems with urination, lack of appetite, and changes in taste were unique to older patients.

                          For symptom distress, two symptoms (i.e., problems with sexual interest, constipation) were ranked as the first or second most distressing symptom in the two age groups. Six of 10 symptoms (60%) were in the top 10 for both age groups. Nausea, feeling bloated, feeling sad, and I don’t look like myself were unique to younger patients. Problems with urination, shortness of breath, difficulty swallowing, and swelling of arms or legs were unique to older patients.

                          Discussion

                          This study is the first to evaluate for differences in multiple dimensions of the symptom experience (i.e., occurrence, severity, frequency, and distress) between older and younger adults undergoing active treatment for cancer. The majority of the age differences were found in ratings of symptom occurrence with older patients reporting significantly lower occurrence rates for 15 (46.9%) of the MSAS symptoms. While fewer age-related differences were found in ratings of symptom severity, frequency, and distress, for younger and older patients who reported a specific symptom, a similar pattern was found across all three dimensions, namely when differences occurred older patients reported significantly lower ratings.

                          While this secondary analysis provides interesting and important data on age-related differences in various dimensions of the symptom experience in a very large sample of oncology patients, several limitations need to be acknowledged before our findings are placed within the context of an extremely limited literature. First, detailed information was not available on the exact number or specific types of comorbidities these patients experienced. In addition, specific details on the doses of CTX and RT received by these patients were not collected for these studies. Despite these limitations, findings from this initial analysis can be used to generate testable hypotheses for future research.

                          For almost 50% of the MSAS symptoms, older patients reported significantly lower occurrence rates. However, eight of the eleven symptoms with the highest occurrence rates were identical in the two age groups (i.e., lack of energy, pain, feeling drowsy, difficulty sleeping, dry mouth, difficulty concentrating, worrying, feeling irritable). Consistent with previous studies of multiple symptoms [15, 3539], these eight symptoms are among the most common symptoms reported by oncology patients regardless of cancer diagnosis, stage of disease, and/or cancer treatment. Since these eight symptom occurrence rates exhibit a similar distribution pattern in both age groups, one plausible hypothesis for the significantly lower occurrence rates for six of these symptoms in older patients (no difference in lack of energy or dry mouth) is that older patients received lower doses of CTX or RT [3, 12, 14, 40]. An equally plausible hypothesis is that older patients received comparable doses of therapy. However, because of age-related changes in a number of biological processes [41] and/or a variety of psychosocial factors [42, 43], older patients reported lower symptom occurrence rates. For example, age-related changes may occur in the hypothalamic-adrenal-pituitary axis (HPA) that mediate the occurrence and severity of the most common cancer-related symptoms [44].

                          Another plausible hypothesis for the lower symptom occurrence rates in older patients is that older persons may experience a “response shift” in their perception of symptoms. A “response shift” is defined as an age-related psychological shift that represents a change in a person’s internal framework for the assessment of experiences [45]. This concept was first used in oncology to describe changes over time in QOL [46]. In the context of older patients’ reports of symptoms, these individuals may have experienced an internal reconceptualization of their symptom experience based on their lifetime experience with symptoms or their experience with symptoms from other chronic medical conditions [45]. In addition, based on studies of barriers to pain assessment and management in older adults [47], older patients tend to under-report pain because: they view it as a normal part of aging; they are concerned that if they report pain it will distract their clinician from treating their cancer; they are fearful about additional diagnostic tests and their associated costs; or they are worried about additional treatments (e.g., opioid analgesics for pain) and associated adverse events [11, 48, 49]. It is plausible that these same barriers contribute to under-reporting of other symptoms in older adults. Cough and shortness of breath were among the top most frequently occurring symptoms only in the older age group. In contrast, feeling sad and sweats were unique to the younger age group. These differences in patterns of occurrence warrant investigation in future studies.

                          For older and younger patients who reported a specific symptom, severity ratings for the majority of the symptoms were mild to moderate. For all but six symptoms (i.e., dry mouth, feeling drowsy, feeling sad, sweats, worrying, I don’t look like myself), no age-related differences in severity scores were reported (see Table 3). In addition to the hypotheses stated above, several potential explanations for the lack of differences in symptom severity ratings warrant consideration. If younger patients received higher doses of RT and/or CTX than older patients, one would expect higher symptom severity scores in the younger group. One potential explanation for the equivalent symptom severity scores is that younger patients received more aggressive symptom management than older patients. This hypothesis is supported by studies that found that older patients receive lower doses of opioid analgesics than younger patients with comparable pain severity scores [50, 51].

                          In terms of the occurrence rates for specific symptoms (see Table 8), seven of the ten symptoms with the highest severity ratings were the same in both age groups (i.e., problems with sexual interest, hair loss, constipation, difficulty sleeping, swelling of arms or legs, lack of energy, pain). A similar pattern for the most severe symptoms across age groups suggests that these symptoms are common across cancer treatments. The age differential in terms of actual severity ratings may be related to dose reductions in the elderly or due to other biological or psychological mechanisms described above. Similar hypotheses could be proposed to explain the age-related differences in the symptom frequency ratings.

                          While a “response shift” in older persons’ perceptions of their symptoms is a plausible explanation for the lower occurrence rates for over 50% of the MSAS symptoms, one might ask why this same hypothesis does not seem to apply for the other dimensions of the symptom experience. One reason that a “response shift” may not be as evident in patients’ ratings of symptom severity, frequency, and distress is that the age group comparisons for these three dimensions were done with only patients who reported the symptom. To verify this hypothesis, differences in symptom severity scores between older and younger patients were re-analyzed with the inclusion of patients who did not report each symptom (i.e., symptom severity scores ranged from 0 to 4 instead of from 1 to 4). In these analyses, compared to younger patients, older patients reported significantly lower severity scores for: difficulty concentrating, pain, lack of energy, feeling nervous, nausea, feeling drowsy, difficulty sleeping, feeling bloated, vomiting, feeling sad, problems with sexual interest, feeling irritable, worrying, I don’t look like myself, and changes in skin. This finding suggests that in older patients who develop a symptom as a result of their cancer or its treatment, they experience it with a similar severity as younger patients. The reasons why some older patients do and do not experience cancer symptoms warrants investigation in future studies.

                          Besides occurrence, the largest number of age-related differences were found in the symptom distress ratings (i.e., for 43.8% of the symptoms, older patients reported significantly lower ratings). Symptom distress is defined as the degree or amount of physical or mental upset, anguish, or suffering experienced from a specific symptom [26, 52]. In one review [39], out of 22 studies that assessed multiple symptoms in cancer patients, only seven (31.8%) assessed distress. Of those seven, three used the MSAS [39]. While no studies were found that evaluated for age differences in MSAS symptom distress ratings, the symptoms with the highest distress ratings in our study are comparable to those found in other studies that used the MSAS [5355].

                          As shown in Table 8, six of the ten most distressing symptoms were the same in both age groups (i.e., constipation, problems with sexual interest, lack of energy, pain, difficulty sleeping, worrying). Problems with urination, difficulty swallowing, swelling of the arms or legs, and shortness of breath were among the top most distressing symptoms in the older age group. In contrast, I don’t look like myself, feeling sad, feeling bloated, and nausea were unique to the younger age group. These differences in distress patterns warrant additional research.

                          Of note, no age-related differences were found in symptom distress ratings for constipation and problems with sexual interest. These two symptoms which occurred in approximately 30% of the patients in both age groups warrant a careful assessment because when they do occur, they are severe, occur frequently, and are distressing not only to older patients, but to younger patients as well.

                          A surprising finding in this study was that a significantly higher percentage (26%) of older patients reported being fully active compared to younger patients (15.8%). While older individuals in the general population are more likely to report poorer functional status than younger individuals [56], the higher functional status in the older patients in this study may be attributed to lower recruitment rates among the oldest old. An alternative explanation is that younger patients received higher doses of CTX or RT that had a negative impact on their functional status.

                          Despite the limitations enumerated earlier in the discussion, findings from this study provide valuable information to guide clinical practice and research. As shown in Table 8, across all four symptom dimensions, the most common, severe, frequent, and distressing symptoms are similar for both age groups. What differs is the magnitude estimation for each dimension, with older persons reporting lower rates of occurrence, severity, frequency, and distress for some symptoms. Because the age-related differences in symptom severity, frequency, and distress scores were small, additional research is warranted within each age group to determine the impact of each dimension of a symptom on younger and older patients’ functional status and QOL.

                          The findings summarized in Table 8 provide new information on symptoms with the highest occurrence, severity, frequency and distress ratings in both age groups. This information can be used by clinicians to guide their multidimensional symptom assessments of older oncology patients. Future research needs to focus on a detailed evaluation of patient (i.e., phenotypic and genotypic characteristics) and clinical characteristics that explain the age differences in the various dimensions of the symptom experience described in this study.

                          Conclusions

                          This study is the first to evaluate for differences in multiple dimensions of symptom experience in older oncology patients. For almost 50% of the MSAS symptoms, older patients reported significantly lower occurrence rates. While fewer age-related differences were found in ratings of symptom severity, frequency, and distress, a similar pattern was found across all three dimensions. Future research needs to focus on a detailed evaluation of patient and clinical characteristics (i.e., type and dose of treatment) that explain the differences in symptom experience identified in this study.

                          Abbreviations

                          CTX: 

                          Chemotherapy

                          ECOG: 

                          Eastern Cooperative Oncology Group

                          FPS: 

                          Fatigue, Pain, and Sleep

                          HPA: 

                          Hypothalamic-adrenal-pituitary axis

                          MSAS: 

                          Memorial Symptom Assessment Scale

                          QOL: 

                          Quality of life

                          RT: 

                          Radiation therapy

                          UCSF: 

                          University of California, San Francisco.

                          Declarations

                          Acknowledgements

                          This collaborative project was funded by Atlantic Philanthropies, and a Queensland University of Technology Institute of Health and Biomedical Innovation Human Health and Wellbeing Collaborative Grant Scheme 2010. The Australian study was funded under a Palliative Care National Health and Medical Research Council grant. The FPS study was funded by the National Institute of Nursing Research (NR04835).

                          Authors’ Affiliations

                          (1)
                          School of Nursing, University of California
                          (2)
                          Schools of Nursing Medicine, University of California
                          (3)
                          School of Nursing, Queensland University of Technology
                          (4)
                          Institute for Human Genetics, University of California
                          (5)
                          Department of Physiological Nursing, University of California

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                          57. Pre-publication history

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                          © Cataldo et al.; licensee BioMed Central Ltd. 2013

                          This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.