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Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells

  • Eduardo C Filippi-Chiela1,
  • Marcos Paulo Thomé1,
  • Mardja Manssur Bueno e Silva1,
  • Alessandra Luíza Pelegrini1,
  • Pitia Flores Ledur1,
  • Bernardo Garicochea4, 5,
  • Lauren L Zamin3 and
  • Guido Lenz1, 2Email author
BMC Cancer201313:147

DOI: 10.1186/1471-2407-13-147

Received: 16 December 2012

Accepted: 19 March 2013

Published: 22 March 2013

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
16 Dec 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
16 Jan 2013 Reviewed Reviewer Report - Renata Cozzi
19 Jan 2013 Reviewed Reviewer Report - Enrique Castellon
14 Feb 2013 Author responded Author comments - Guido Lenz
Resubmission - Version 3
14 Feb 2013 Submitted Manuscript version 3
27 Feb 2013 Reviewed Reviewer Report - Renata Cozzi
11 Mar 2013 Reviewed Reviewer Report - Enrique Castellon
Resubmission - Version 4
Submitted Manuscript version 4
Publishing
19 Mar 2013 Editorially accepted
22 Mar 2013 Article published 10.1186/1471-2407-13-147

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Biophysics, Universidade Federal do Rio Grande do Sul (UFRGS), Rua Bento Gonçalves
(2)
Center of Biotechnology, Universidade Federal do Rio Grande do Sul (UFRGS)
(3)
Universidade Federal da Fronteira Sul (UFFS)
(4)
Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
(5)
Oncology Center - Hospital Sirio Libanes

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