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Fatal case of sorafenib-associated idiosyncratic hepatotoxicity in the adjuvant treatment of a patient with renal cell carcinoma

  • BP Fairfax1,
  • S Pratap1,
  • ISD Roberts4,
  • J Collier5,
  • R Kaplan2,
  • AM Meade2,
  • AW Ritchie2,
  • T Eisen3,
  • VM Macaulay1 and
  • A Protheroe1Email author
BMC Cancer201212:590

DOI: 10.1186/1471-2407-12-590

Received: 16 April 2012

Accepted: 29 November 2012

Published: 11 December 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
16 Apr 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
Resubmission - Version 3
Submitted Manuscript version 3
18 Jul 2012 Reviewed Reviewer Report - Henning Wege
23 Jul 2012 Reviewed Reviewer Report - R E Ferner
31 Aug 2012 Author responded Author comments - Benjamin Fairfax
Resubmission - Version 4
31 Aug 2012 Submitted Manuscript version 4
29 Nov 2012 Editorially accepted
11 Dec 2012 Article published 10.1186/1471-2407-12-590

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Department of Oncology, Cancer and Haematology Centre, Churchill Hospital
MRC Clinical Trials Unit
Cambridge Biomedical Research Centre
Department of Cellular Pathology, John Radcliffe Hospital
Department of Gastroenterology, John Radcliffe Hospital