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Breast ductal lavage for biomarker assessment in high risk women: rationale, design and methodology of a randomized phase II clinical trial with nimesulide, simvastatin and placebo

  • Matteo Lazzeroni1Email author,
  • Aliana Guerrieri-Gonzaga1,
  • Davide Serrano1,
  • Massimiliano Cazzaniga1,
  • Serena Mora1,
  • Chiara Casadio2,
  • Costantino Jemos3,
  • Maria Pizzamiglio4,
  • Laura Cortesi5,
  • Davide Radice6 and
  • Bernardo Bonanni1
BMC Cancer201212:575

DOI: 10.1186/1471-2407-12-575

Received: 31 October 2012

Accepted: 29 November 2012

Published: 5 December 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
31 Oct 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
7 Nov 2012 Author responded Author comments - Matteo Lazzeroni
Resubmission - Version 3
7 Nov 2012 Submitted Manuscript version 3
29 Nov 2012 Editorially accepted
5 Dec 2012 Article published 10.1186/1471-2407-12-575

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Division of Cancer Prevention and Genetics, European Institute of Oncology
Unit of Diagnostic Cytology, Division of Pathology and Laboratory Medicine, European Institute of Oncology
Hospital Pharmacy, European Institute of Oncology
Breast Radiology Unit, European Institute of Oncology
Department of Oncology & Haematology of the University of Modena and Reggio Emilia
Department of Epidemiology and Biostatistics, European Institute of Oncology