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Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses

  • D Alan Anthoney1,
  • Jay Naik1,
  • Iain RJ MacPherson2,
  • Donna Crawford2,
  • John M Hartley3,
  • Janet A Hartley3,
  • Tomohisa Saito4,
  • Masaichi Abe4,
  • Keith Jones5,
  • Masanori Miwa4,
  • Christopher Twelves1Email author and
  • TRJ Evans2
BMC Cancer201212:536

DOI: 10.1186/1471-2407-12-536

Received: 29 February 2012

Accepted: 6 November 2012

Published: 21 November 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
29 Feb 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
5 Mar 2012 Author responded Author comments - KEITH JONES
Resubmission - Version 3
5 Mar 2012 Submitted Manuscript version 3
25 Mar 2012 Reviewed Reviewer Report - Laurent Rivory
7 Apr 2012 Reviewed Reviewer Report - Mark McKeage
28 May 2012 Author responded Author comments - KEITH JONES
Resubmission - Version 4
28 May 2012 Submitted Manuscript version 4
6 Nov 2012 Editorially accepted
21 Nov 2012 Article published 10.1186/1471-2407-12-536

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article.. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

St James Institute of Oncology, University of Leeds & Leeds Teaching Hospitals Trust
University of Glasgow, Beatson West of Scotland Cancer Centre
UCL Cancer Institute, Paul O’Gorman Building, University College London
Chugai Pharmaceutical Co., Ltd
Chugai Pharmaceuticals Europe Ltd. Turnham Green