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BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

  • Stephane Boeuf1,
  • Judith VMG Bovée2,
  • Burkhard Lehner3,
  • Brendy van den Akker2,
  • Maayke van Ruler2,
  • Anne-Marie Cleton-Jansen2 and
  • Wiltrud Richter1Email author
BMC Cancer201212:488

DOI: 10.1186/1471-2407-12-488

Received: 16 March 2012

Accepted: 2 October 2012

Published: 22 October 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
16 Mar 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
16 Apr 2012 Reviewed Reviewer Report - John Healey
6 May 2012 Reviewed Reviewer Report - Nita Ahuja
16 Jun 2012 Author responded Author comments - Wiltrud Richter
Resubmission - Version 3
16 Jun 2012 Submitted Manuscript version 3
15 Jul 2012 Reviewed Reviewer Report - John Healey
6 Sep 2012 Author responded Author comments - Wiltrud Richter
Resubmission - Version 4
6 Sep 2012 Submitted Manuscript version 4
Publishing
2 Oct 2012 Editorially accepted
22 Oct 2012 Article published 10.1186/1471-2407-12-488

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Research Centre for Experimental Orthopaedics, Department of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital
(2)
Department of Pathology, Leiden University Medical Center
(3)
Division of Orthopaedic Oncology, Department of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital

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