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Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1)

  • Katrin Oertel1,
  • Karin Spiegel1,
  • Harald Schmalenberg2,
  • Andreas Dietz3,
  • Georg Maschmeyer4,
  • Thomas Kuhnt5,
  • Holger Sudhoff6,
  • Thomas G Wendt7 and
  • Orlando Guntinas-Lichius1Email author
BMC Cancer201212:483

DOI: 10.1186/1471-2407-12-483

Received: 22 June 2012

Accepted: 18 October 2012

Published: 20 October 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
22 Jun 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
21 Aug 2012 Reviewed Reviewer Report - Hans Edmund Eckel
2 Sep 2012 Reviewed Reviewer Report - gerges attia
1 Oct 2012 Author responded Author comments - Orlando Guntinas-Lichius
Resubmission - Version 3
1 Oct 2012 Submitted Manuscript version 3
18 Oct 2012 Editorially accepted
20 Oct 2012 Article published 10.1186/1471-2407-12-483

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Department of Otorhinolaryngology, Jena University Hospital
Department of Medicine II, Jena University Hospital
Department of Otorhinolaryngology/Plastic Surgery, University Hospital Leipzig
Department of Hematology, Oncology & Palliative Care, Klinikum Ernst von Bergmann
Department of Radiation Oncology, University of Rostock
Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum Bielefeld
Department of Radiation Oncology, Jena University Hospital