Exercise and nutrition for head and neck cancer patients: a patient oriented, clinic-supported randomized controlled trial
© Capozzi et al.; licensee BioMed Central Ltd. 2012
Received: 10 September 2012
Accepted: 23 September 2012
Published: 2 October 2012
Research on physical activity and nutrition interventions aimed at positively impacting symptom management, treatment-related recovery and quality of life has largely excluded head and neck (HN) cancer populations. This translates into a lack of clinical programming available for these patient populations. HN cancer patients deal with severe weight loss, with more than 70% attributed to lean muscle wasting, leading to extended recovery times, decreased quality of life (QoL), and impaired physical functioning. To date, interventions to address body composition issues have focused solely on diet, despite findings that nutritional therapy alone is insufficient to mitigate changes. A combined physical activity and nutrition intervention, that also incorporates important educational components known to positively impact behaviour change, is warranted for this population. Our pilot work suggests that there is large patient demand and clinic support from the health care professionals for a comprehensive program.
Therefore, the purpose of the present study is to examine the impact and timing of a 12-week PA and nutrition intervention (either during or following treatment) for HN cancer patients on body composition, recovery, serum inflammatory markers and quality of life. In addition, we will examine the impact of a 12-week maintenance program, delivered immediately following the intervention, on adherence, patient-reported outcomes (i.e., management of both physical and psychosocial treatment-related symptoms and side-effects), as well as return to work.
This research will facilitate advancements in patient wellness, survivorship, and autonomy, and carve the path for a physical-activity and wellness-education model that can be implemented in other cancer centers.
Current Controlled Trials NCT01681654
KeywordsHead/neck cancer Exercise Progressive strength training Quality of life Cancer Randomized controlled trial Nutrition Lifestyle intervention
Head and neck (HN) cancers include cancers of the lip, oral cavity, oropharynx, hypopharynx, tonsil, salivary glands, nasopharynx, nose paranasal sinus, and middle ear . They are the sixth most common cancer worldwide . HN cancers account for approximately 3% of all cancers in the United States and are nearly twice as common among men as they are among women . In 2011, approximately 52,000 people in the United States were diagnosed with HN cancers and over 5000 in Canada, and the 5-year survival rate is currently at 57% [1, 3]. Advances in medical detection and interventions are helping to increase 5-year overall cancer survival rates, leading to an ever-growing number of cancer survivors . Since the long-lasting effects of the disease and treatments may impact all survivors, the focus on survivorship care and patient outcomes is paramount .
There is persuasive evidence to suggest that two lifestyle behaviors, physical activity (PA) and nutrition are necessary components in cancer survivorship programming . PA has been shown to enhance patient functional capacity, physical functioning, and body composition, as well as facilitate the management of treatment related symptoms and side-effects including fatigue, and nausea [7–11]. Nutritional counseling has been found to improve dietary intake in patients who face increased risk of malnutrition, thereby improving outcomes and timely healing [12, 13]. It is well established that PA and nutrition interventions also promote improved quality of life (QoL) in cancer survivors, regardless of tumour site. To date, the vast majority of lifestyle interventions have focused their attention on breast cancer [12, 14–16]. This has left other cancer populations drastically underserved, including HN cancer survivors, who are at significant risk of long-term disability .
While HN cancer patients face issues similar to other cancer survivor populations (i.e., fatigue, distress, physical functioning), these populations also experience further physical and psychological burden into survivorship, affecting overall QoL status, rehabilitation, and return to work [17–21]. HN cancer patients deal with severe weight loss, with upwards of 70% attributed to lean muscle wasting, leading to decreased physical functioning with regards to locomotion, strength and respiration after treatment [19, 22]. This cancer-related skeletal muscle wasting, or cachexia, exists due to imbalances between muscle protein synthesis and degradation, and is unique from starvation in the sense that it cannot be reversed or treated solely with nutritional supplementation . Cachexia is defined as an unintentional weight loss of at least 5% premorbid weight occurring over 3 to 6 months and will be the main cause of death for 20-40% of HN cancer patients, a group especially challenged with this syndrome [23, 24].
Current interventions are largely focused on nutrition, despite findings indicating that decreased food intake is probably not directly related to this muscle wasting, and that dietary intervention alone may increase fat mass without affecting muscle tissue . Couch et al. (2007) also reported that although nutritional therapy is necessary, alone it might be insufficient, prompting additional or complementary treatment options . At present there is a lack of complementary treatment options to help sustain or rebuild this wasted muscle, yet since cachexia is a muscle wasting disease, interventions targeted at increasing protein anabolism and decreasing catabolism are warranted . Strength training and exercise hold great potential due to the associated increases in lean muscle mass and improvements in body composition, which have been seen in other cancer populations [8, 27]. Currently, there are very few clinical trials that examine the impact of strength training in combination with a nutritional intervention for cachexia. Besides the negative impact on overall health and survival, this muscle wasting syndrome is associated with substantial mental and emotional fatigue, and significantly decreased QoL, particularly in scores of emotional, physical and social functioning categories [18, 23, 24, 28, 29]. Exercise and diet have been found to enhance QoL in HN survivors and help manage fatigue, but the specific benefits of a lifestyle intervention during treatment has yet to be investigated, and the question pertaining to the appropriate time of intervention, during treatment or following treatment, has yet to be answered [17, 30].
The purpose of this proposed research is to examine the immediate and long term physical and psychosocial benefits of a clinic-supported physical activity and nutrition program during and after treatment for HN cancer survivors, and to investigate the clinical implications associated with increasing the promotion of healthy lifestyle behaviors for this population. This research will address the pressing need for clinic-supported HN cancer lifestyle interventions that effectively demonstrate physical and psychosocial patient benefit.
Whether a lifestyle intervention will improve outcomes, including physiological (muscle mass maintenance), fitness, psychological (QoL and depression), smoking status, inflammatory markers, and functional (return to work).
Whether it is optimal, in terms of outcomes, to deliver the program during or after treatment completion.
Whether a survivorship care plan (SCP) maintenance program improves long-term healthy lifestyle adherence.
Without exploration into these questions, HN cancer care will continue to only partially serve patients in their quest towards healthy cancer recovery, strong physical functioning ability, improved QoL, and timely return to work. These studies will provide concrete evidence for a clinic-supported lifestyle intervention and maintenance program as a means to mediate these currently unaddressed factors and improve functioning and psychosocial outcomes.
The study hypotheses directly reflect the aims. It is hypothesized that patients who are randomized to the 12-week lifestyle intervention at treatment start will experience improved symptom management throughout treatment compared to controls (delayed intervention) as evaluated by: a) decreased loss of lean body mass, improved physical functioning and fitness outcomes, improved Karnofsky Performance scores and decreased levels of serum inflammatory markers b) improved patient sense of wellbeing and feelings of control and therefore overall reported QoL. It is also hypothesized that patients who are randomized to the 12-week lifestyle intervention at treatment start (immediate intervention) will experience improved symptom management following treatment compared to delayed intervention patients who begin the 12-week intervention following treatment. Improved symptom management will be evaluated following intervention by: a) decreased loss of lean body mass, improved physical functioning and fitness outcomes, improved Karnofsky Performance scores and decreased levels of serum inflammatory markers as well as the associated b) improvement in patient sense of wellbeing, feelings of control, and overall reported QoL score.
Once enrolled, the participant will be randomized to either begin the intervention at the time of treatment initiation (ILI, n = 40), or to begin the intervention following treatment completion (DLI, n = 40). Patients will be recruited, cleared for participation, receive an initial assessment, and then be randomized into either the ILI group or the DLI group. Participants in the ILI group will receive an individualized exercise and dietary program based on their exercise assessment and dual energy x-ray absorptiometry (DXA) scan results, will attend twice weekly group exercise classes, and perform their individualized at-home program an additional two times per week. In addition, participants will be required to attend six education sessions during the 12-week intervention. The DLI group will receive this intervention upon their treatment completion, at approximately 12-weeks post-randomization.
Physical activity intervention
Participants will attend twice weekly exercise classes, for 12 weeks, at the Thrive Centre or Tom Baker Cancer Centre Holy Cross location to practice their program in a supported group-based environment. In addition, participants will receive equipment to perform the program at least two days per week at home. The focus of the PA program will be progressive strength training, helping to rebuild lost muscle mass and prevent further protein degradation. Participants will be asked to perform 8-10 prescribed low-intensity exercises four times per week, conducting approximately 2 sets of 8-10 repetitions. During this time, participants will be asked to record daily activity in a PA log.
Patients will be screened weekly using the Patient Generated-Subjective Global Assessment tool (PG-SGA) during treatment and will complete a 3-day dietary record at baseline, four weeks, eight weeks, and then at each assessment point thereafter [31, 32]. This information will be scored and a dietitian will review and provide appropriate feedback at weekly dietary counseling sessions.
The educational seminars will focus on providing both nutrition and PA information that will aid in the preparation for behavior change. Specifically, weekly education classes addressing the impact of lifestyle choices on treatment-related symptoms and outcomes, teaching behavior change techniques (goal setting, journaling etc.), and providing time for supportive discussion will be held immediately after an exercise session one time/week.
Following the initial intervention, participants in both the immediate and delayed intervention arms will be randomized (20:20 in each group) to either a control (no maintenance program other than access to the workout center) or a 12-week maintenance program immediately following the intervention, consisting of an SCP with both exercise and dietary prescriptions, weekly group-based PA classes, and ongoing monthly education classes.
The intervention participants will consist of HN patients who have been newly diagnosed and who have not yet started treatment. Patients will be eligible to participate if they: 1) are over 18 years of age 2) have received a diagnosis of nasopharyngeal, oropharyngeal or hypopharygeal cancer, 3) are scheduled to receive radiation treatment, 4) are able to walk without assistance, 5) have received clearance for exercise from their treating oncologist, 6) live in the Calgary area 7) can speak and write English, and 8) are interested in participating in the program. Reasons for exclusion will be documented as feasibility outcomes of the trial.
Participants will be recruited through the HN clinic at the Tom Baker Cancer Centre, with direct referral and clearance for exercise from a physician. Once the participant is referred, they will be contacted to discuss the study details and, if interested and meet the inclusion criteria, will receive an appointment time for an initial assessment. At this time, participants will complete a written, informed consent before participation in the study.
The assessments will consist of a battery of patient-reported instruments to assess demographics, medical information, PA and dietary behavior, QoL, depression, smoking status as well as a physical fitness assessment and a comprehensive body composition assessment. Inflammatory markers, including TNF, IL-6, IL-1, IL-8 and C-reactive protein will be assessed in serum. A chart review will also be conducted to assess diagnosis, treatment plan and outcomes. The assessment will take approximately 1.5 hours to complete and will occur at baseline (time of diagnosis), 3, 6, 9, and 12-months post diagnosis.
Health and lifestyle questionnaires
Demographics will be collected by self-report including gender, age, ethnicity, marital status, education, employment status, return to work status and annual income. Medical variables, abstracted from chart reviews by study staff, will include specific diagnosis (type, stage, initial or recurrence), time since diagnosis, and current treatment.
Physical activity behaviour
PA will be assessed using Godin’s leisure score index (LSI) of the GLTEQ (Godin Leisure Time Exercise Questionnaire) . The LSI is a 3-item measure assessing the frequency and duration of mild, moderate and strenuous bouts of exercise performed during free time in a typical week. In this study, participants will be asked to recall their exercise levels over the past month. The LSI has been successfully used with adult cancer patients and survivors, and has good reliability and validity as indicated by an independent evaluation to nine other self-report measures of exercise [34–36].
Quality of life
QoL will be assessed using the Functional Assessment of Cancer Therapy- Anemia module (FACT-AN), and the NCCN-FACT Fact Head/Neck Symptom Index-22 (FHNSI-22). These tools examine the 5 major subsets of well-being for cancer survivors, including physical well-being, social/family well-being, emotional well-being, functional well-being, and additional concerns specific to HN cancer survivors. Based on these scales, the Trial Outcome Index (TOI) will be calculated, providing a final score based on the sum of the subscales.
Depression will be assessed using the Center for Epidemiological Studies on Depression Scale (CES-D). This 20-item questionnaire screens for self-reported depressive symptoms . It has shown excellent internal consistency in the cancer population with perfect sensitivity and strong specificity in a study of 33 cancer patients .
Smoking history will be assessed by a self-report questionnaire. This questionnaire will classify patients as non-smokers, former smokers and current smokers.
Weekly PA logs
Participants will complete daily PA logs. These logs will highlight daily activities, the intensity of those activities (1-10 Rated Perceived Exertion Scale), and the duration of those activities.
Biweekly Edmonton symptom assessment system (ESAS)
Participants will complete the ESAS bi-weekly, before and after class. The ESAS is a valid and reliable assessment tool to evaluate the nine more common symptoms experienced by cancer patients .
Diet will be assessed using a 3-day Diet Record once per month, and the PG-SGA will be completed once per week. The 3-Day Diet Record is said to be the most accurate for mean macronutrient content and appropriate for use in studies where subjects may consume a wide variety of foods [40, 41]. Participants are instructed to record their daily consumption, including alcohol intake, over a period of three days, one of which must be a weekend day. Written instructions and a sample entry are provided to increase accuracy of the daily record. The PG-SGA assessment tool has been show to improve treatment outcomes, decrease side-effects, and improve weight-management in cancer patients, and therefore will be used weekly to assess and identify malnutrition among patients [31, 32].
Health-related fitness assessments
Standing height and weight will be measured on a Heath Carter balance beam scale. Participants will be weighed weekly during active treatment and during the lifestyle intervention and maintenance phase. Weight will also be tracked at each of the 5 assessments. Waist circumference will be measured with an anthropometric tape measure at the top of the iliac crest and hip circumference will be measured at the greatest girth of the gluteus with the participant standing erect . Waist to hip ratio and body mass index (kg × m-2) will be calculated . A DXA scan (Hologic QDR 4500; Hologic Inc, Bedford, MA) will be performed a total of five times, at each assessment. Hologic QDR software will be used to determine lean mass, fat mass and bone mineral density. The DXA scans will be done at the Human Performance Laboratory at the University of Calgary.
Although aerobic fitness is not the specific focus of the exercise intervention, the resistance training may likely have ancillary impact on cardiorespiratory fitness. While a submaximal cardiorespiratory test would be the standard, due to the limitations in this patient population, a functional measure of aerobic fitness was deemed to have greater value, as well as be more reflective of the training focus in the intervention. Resting heart rate will be measured using a heart rate monitor (Polar) and resting blood pressure (mmHg) will be measured in duplicate on the left arm using a sphygmomanometer and stethoscope using standardized procedures . Rating of perceived exertion (Borg scale) will be completed immediately prior to and immediately after completion of the functional aerobic capacity test. The six-minute walk test (6MWT) will be used to assess changes in functional aerobic capacity. Using the standardized protocol, participants will be asked to walk as far as they can around a 400-meter track for six minutes . The point reached at 6 minutes will be marked and measured to the nearest 0.5 meter. Post-exercise HR and BP will be measured one minute after a standard cool-down and after sitting quietly for five minutes before dismissal from the fitness-testing laboratory.
Muscular strength will be assessed using a combined grip strength of the right and left hands using a hand dynamometer. A sum will be determined in kilograms from the best score of 2 trials recorded for each hand according to the CPAFLA protocol . Lower body strength will be assessed using a 30-second sit to stand test. The number of times participants can stand from a seated position in 30-second will be examined .
Flexibility will be assessed by a trunk forward flexion sit-and-reach test using a Wells-Dillon flexometer. The test will follow a standard protocol, with two trials allowed and the highest score to the nearest 0.5 cm recorded .
Balance will be assessed using a static balance test. The test requires the participant to balance on one foot and then the other as long as they can (length of time) while standing on a 2.54 by 2.54 by 30.5 cm base using a standardized protocol, reported by Fleishman .
Measures of physical functioning
Participant performance score
The Karnofsky Performance Score (KPS) will be used to measure the participant’s general ability to accomplish tasks of daily-living and overall well-being. The Score is used to reflect the patient’s performance or function and ability to work, and is practical, objective, and has been validated and used for the past 50 years .
Blood data collection
Inflammatory factors will be evaluated as they are associated with cancer cachexia and muscle wasting and may be modified by exercise [47, 48]. An overnight fasted blood draw will be collected at baseline, 3 months post diagnosis, 6 months post diagnosis, 9 months post diagnosis, and 12 months post diagnosis. Once further funding is secured, serum inflammatory cytokine concentrations will be assessed in-house (Dr. Raylene Reimer’s laboratory) according to our established protocols. TNF, IL-6, IL-1, IL-8 and C-reactive protein will be quantified using Milliplex Human Cytokine kits (Millipore, Billerica, MA). Plate reading will be provided as a fee-for service through Eve Technologies Inc. (Calgary, AB).
Sample size calculation
Sample size calculations are based on minimum participants required for a linear mixed models analysis as derived from Schmitz et al. . They suggest a strong relationship between strength training and improvements in lean tissue in cancer patients. The power calculation was derived using G-Power [49, 50]. The effect size of 0.63 was calculated based on relevant literature associated with similar interventions and α = 0.05 and β = 0.80 were used [22, 27]. Based on these numbers, it was determined that a power of n = 32 is required for each group. Accounting for potential participant drop-out, a 20% buffer will be added and a total of n = 40 for each group, for a total n = 80. All intervention participants will be recruited for the intervention over year one of the study. Preliminary data from the EHNANCE exercise program for HN patients indicates that this recruitment goal is feasible (36 patients recruited in 4 months, with adherence at 90%).
Analyses will include feasibility (participants recruited; program attendance), descriptive analyses and statistical tests examining change over the program duration. The raw data will be analyzed using SPSS Version 19.0, and will primarily consist of linear mixed models. Information from the 3-Day Diet Records will be analyzed with Diet Analysis Plus 10.0 software (Wadsworth Inc.) to generate total daily energy intake, macronutrient and micronutrient intake for each participant. The resultant data will be analyzed using SPSS.
For the primary objective, we will be utilizing linear mixed models analyses, to examine change between groups and over time, with the primary outcome being body composition changes over time and between the two groups (immediate intervention and delayed intervention).
For the secondary objective, we will also examine change over time in health related fitness, QoL, functional status (Karnofsky), dietary intake, and markers of inflammation.
Protection against bias
To protect against bias, participants will be randomly assigned to one of the two intervention arms, using randomization.com, a web-based random number generation program with a 1:1 allocation ratio. Exercise testers who will be evaluating participant fitness measures will be blinded to participant allocation. When participants are recruited, they will be told that there is an equal possibility that they will be assigned to one of the two groups (immediate lifestyle intervention or the delayed lifestyle intervention group) and that the impact of intervention timing is not yet known. Once they have completed their initial assessment, they will be contacted by the research coordinator and told which group they have been allocated and receive an explanation of the protocol and their responsibilities.
HN cancer survivors are at an increased risk for physical and psychological burden into survivorship, with many complications related to weight loss and muscle wasting [19, 22]. This has direct implications on patient QoL, rehabilitation, and return to work [17–21]. The proposed study will provide a wide-ranging investigation into the impact of PA, diet screening and education on body composition before and following treatments. This work will specifically address whether a lifestyle approach can help to preserve muscle mass and whether there is a link between body composition and patient reported outcomes, such as QoL. The goal of this research is to address a current unmet need and respond directly to patient demand for comprehensive, patient-centered care by delivering an intervention combining PA, nutritional and educational elements. This intervention will target physical and psychosocial well-being, promoting improved management of patients’ physical and psychosocial responses to treatment as well as improving long-term outcomes. Further, this research will evaluate the comparative effectiveness of a comprehensive PA, nutrition and education intervention at different points along the cancer care trajectory, to identify the most effective clinical intervention point in patient care based on rigorously assessed health outcomes. The evidence required for successful clinical adoption and integration of this multidisciplinary clinic-based intervention will be gathered and a model will be built for future program translation. In addition, and crucial to the success of this clinic-based program, an opportunity for advanced collaboration among health care providers will be supported, ultimately enhancing the patient care experience and resulting in improved vital health outcomes.
Head and neck
Quality of life
Immediate lifestyle intervention
Delayed lifestyle intervention
Dual energy x-ray absorptiometry
Patient generated – subjective global assessment tool
Leisure score index
Godin leisure time exercise questionnaire
Functional assessment of cancer therapy anemia
Functional assessment of cancer therapy head neck symptom index-22
Trial outcome index
Studies on depression scale
Edmonton symptom assessment system
Karnofsky performance score.
This study is funded by the Joe’s Team Triathlon, Alberta Cancer Foundation donor-directed funds. Dr. Reimer is supported by funding from the Canadian Institutes of Health Research. Dr. McNeely is supported by funding from the Canadian Institute of Health Research and the Canadian Breast Cancer Foundation – Prairies, NWT Chapter. Dr. Giese-Davis is supported through funded by the Enbridge Research Chair in Psychosocial Oncology (held by Dr. Linda E. Carlson), co-funded by the Alberta Cancer Foundation and the Canadian Cancer Society Alberta/NWT Division. Dr. Culos-Reed is supported by funding from the Canadian Imperial Bank of Commerce.
- Piccirillo J, Costas I, Reichman M, et al: Chapter 2: Cancers of the Head and Neck. Suervaeylance Epidemiology and End Result Survival Monograph. National Cancer Institute. SEER Cancer Statistics Review, 1975-2008, National Cancer Institute. Volume 2012. Edited by: Howlader N, Noone AM, Krapcho M. 2011
- Kamangar F, Dores GM, Anderson WF: Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006, 24 (14): 2137-2150. 10.1200/JCO.2005.05.2308.View ArticlePubMed
- Canadian Cancer Society’s Steering Committee on Cancer Statistics: Canadian cancer statistics 2012. 2012, Toronto, ON: Canadian Cancer Society, 0835-2976.
- Andersen C, Adamsen L, Moeller T, Midtgaard J, Quist M, Tveteraas A, Rorth M: The effect of a multidimensional exercise programme on symptoms and side-effects in cancer patients undergoing chemotherapy–the use of semi-structured diaries. Eur J Oncol Nurs. 2006, 10 (4): 247-262. 10.1016/j.ejon.2005.12.007.View ArticlePubMed
- Yabroff KR, Lawrence WF, Clauser S, Davis WW, Brown ML: Burden of illness in cancer survivors: findings from a population-based national sample. J Natl Cancer Inst. 2004, 96 (17): 1322-1330. 10.1093/jnci/djh255.View ArticlePubMed
- Thomas R, Davies N: Lifestyle during and after cancer treatment. Clin Oncol (R Coll Radiol). 2007, 19 (8): 616-627. 10.1016/j.clon.2007.06.002.View Article
- McNeely M, Peddle C, Parliament M, Courneya K: <br />cancer rehabilitation: recommendations for integrating exercise programming in the clinical practice setting. Current Cancer Therapy Reviews. 2006, 2 (4): 35-View Article
- Courneya KS, Friedenreich CM: Physical activity and cancer control. Semin Oncol Nurs. 2007, 23 (4): 242-252. 10.1016/j.soncn.2007.08.002.View ArticlePubMed
- Mock V, Pickett M, Ropka ME, Muscari Lin E, Stewart KJ, Rhodes VA, McDaniel R, Grimm PM, Krumm S, McCorkle R: Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Pract. 2001, 9 (3): 119-127. 10.1046/j.1523-5394.2001.009003119.x.View ArticlePubMed
- van Weert E, Hoekstra-Weebers J, Otter R, Postema K, Sanderman R, van der Schans C: Cancer-related fatigue: predictors and effects of rehabilitation. Oncologist. 2006, 11 (2): 184-196. 10.1634/theoncologist.11-2-184.View ArticlePubMed
- Winningham ML, MacVicar MG: The effect of aerobic exercise on patient reports of nausea. Oncol Nurs Forum. 1988, 15 (4): 447-450.PubMed
- Ravasco P, Monteiro-Grillo I, Camilo ME: Does nutrition influence quality of life in cancer patients undergoing radiotherapy?. Radiother Oncol. 2003, 67 (2): 213-220. 10.1016/S0167-8140(03)00040-9.View ArticlePubMed
- Ravasco P, Monteiro-Grillo I, Vidal PM, Camilo ME: Nutritional deterioration in cancer: the role of disease and diet. Clin Oncol (R Coll Radiol). 2003, 15 (8): 443-450. 10.1016/S0936-6555(03)00155-9.View Article
- Cheema BS, Gaul CA: Full-body exercise training improves fitness and quality of life in survivors of breast cancer. J Strength Cond Res. 2006, 20 (1): 14-21.PubMed
- Kendall AR, Mahue-Giangreco M, Carpenter CL, Ganz PA, Bernstein L: Influence of exercise activity on quality of life in long-term breast cancer survivors. Qual Life Res. 2005, 14 (2): 361-371. 10.1007/s11136-004-1468-5.View ArticlePubMed
- Speck RM, Courneya KS, Masse LC, Duval S, Schmitz KH: An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. J Cancer Surviv. 2010, 4 (2): 87-100. 10.1007/s11764-009-0110-5.View ArticlePubMed
- Rogers LQ, Courneya KS, Robbins KT, Malone J, Seiz A, Koch L, Rao K, Nagarkar M: Physical activity and quality of life in head and neck cancer survivors. Support Care Cancer. 2006, 14 (10): 1012-1019. 10.1007/s00520-006-0044-7.View ArticlePubMed
- O'Neill M, Heron DE, Flickinger JC, Smith R, Ferris RL, Gibson M: Posttreatment quality-of-life assessment in patients with head and neck cancer treated with intensity-modulated radiation therapy. Am J Clin Oncol. 2011, 34 (5): 478-482.PubMed
- Lenk K, Schuler G, Adams V: Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training. J Cachexia Sarcopenia Muscle. 2010, 1 (1): 9-21. 10.1007/s13539-010-0007-1.PubMed CentralView ArticlePubMed
- Gustafsson M, Edvardsson T, Ahlstrom G: The relationship between function, quality of life and coping in patients with low-grade gliomas. Support Care Cancer. 2006, 14 (12): 1205-1212. 10.1007/s00520-006-0080-3.View ArticlePubMed
- Taylor JC, Terrell JE, Ronis DL, Fowler KE, Bishop C, Lambert MT, Myers LL, Duffy SA, Bradford CR, Chepeha DB, Hogikyan ND, Prince ME, Teknos TN, Wolf GT, University of Michigan Head and Neck Cancer Team: Disability in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg. 2004, 130 (6): 764-769. 10.1001/archotol.130.6.764.View ArticlePubMed
- Silver HJ, Dietrich MS, Murphy BA: Changes in body mass, energy balance, physical function, and inflammatory state in patients with locally advanced head and neck cancer treated with concurrent chemoradiation after low-dose induction chemotherapy. Head Neck. 2007, 29 (10): 893-900. 10.1002/hed.20607.View ArticlePubMed
- Richey LM, George JR, Couch ME, Kanapkey BK, Yin X, Cannon T, Stewart PW, Weissler MC, Shores CG: Defining cancer cachexia in head and neck squamous cell carcinoma. Clin Cancer Res. 2007, 13 (22 Pt 1): 6561-6567.View ArticlePubMed
- Couch M, Lai V, Cannon T, Guttridge D, Zanation A, George J, Hayes DN, Zeisel S, Shores C: Cancer cachexia syndrome in head and neck cancer patients: part I. Diagnosis, impact on quality of life and survival, and treatment. Head Neck. 2007, 29 (4): 401-411. 10.1002/hed.20447.View ArticlePubMed
- MacDonald N, Easson AM, Mazurak VC, Dunn GP, Baracos VE: Understanding and managing cancer cachexia. J Am Coll Surg. 2003, 197 (1): 143-161. 10.1016/S1072-7515(03)00382-X.View ArticlePubMed
- Al-Majid S, Waters H: The biological mechanisms of cancer-related skeletal muscle wasting: the role of progressive resistance exercise. Biol Res Nurs. 2008, 10 (1): 7-20. 10.1177/1099800408317345.View ArticlePubMed
- Schmitz KH, Ahmed RL, Hannan PJ, Yee D: Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteins. Cancer Epidemiol Biomarkers Prev. 2005, 14 (7): 1672-1680. 10.1158/1055-9965.EPI-04-0736.View ArticlePubMed
- Brown JK: A systematic review of the evidence on symptom management of cancer-related anorexia and cachexia. Oncol Nurs Forum. 2002, 29 (3): 517-532. 10.1188/02.ONF.517-532.View ArticlePubMed
- Ledeboer QC, Velden LA, Boer MF, Feenstra L, Pruyn JF: Physical and psychosocial correlates of head and neck cancer: an update of the literature and challenges for the future (1996-2003). Clin Otolaryngol. 2005, 30 (4): 303-319. 10.1111/j.1365-2273.2005.01035.x.View ArticlePubMed
- Paccagnella A, Morello M, Da Mosto MC, Baruffi C, Marcon ML, Gava A, Baggio V, Lamon S, Babare R, Rosti G, Giometto M, Boscolo-Rizzo P, Kiwanuka E, Tessarin M, Caregaro L, Marchiori C: Early nutritional intervention improves treatment tolerance and outcomes in head and neck cancer patients undergoing concurrent chemoradiotherapy. Support Care Cancer. 2010, 18 (7): 837-845. 10.1007/s00520-009-0717-0.View ArticlePubMed
- McMahon K, Brown JK: Nutritional screening and assessment. Semin Oncol Nurs. 2000, 16 (2): 106-112. 10.1053/on.2000.5549.View ArticlePubMed
- Doyle C, Kushi LH, Byers T, Courneya KS, Demark-Wahnefried W, Grant B, McTiernan A, Rock CL, Thompson C, Gansler T, Andrews KS, 2006 Nutrition, Physical Activity and Cancer Survivorship Advisory Committee, American Cancer Society: Nutrition and physical activity during and after cancer treatment: an American cancer society guide for informed choices. CA Cancer J Clin. 2006, 56 (6): 323-353. 10.3322/canjclin.56.6.323.View ArticlePubMed
- Godin G, Shephard RJ: A simple method to assess exercise behavior in the community. Can J Appl Sport Sci. 1985, 10 (3): 141-146.PubMed
- Courneya KS, Friedenreich CM: Determinants of exercise during colorectal cancer treatment: an application of the theory of planned behavior. Oncol Nurs Forum. 1997, 24 (10): 1715-1723.PubMed
- Courneya KS, Friedenreich CM: Relationship between exercise pattern across the cancer experience and current quality of life in colorectal cancer survivors. J Altern Complement Med. 1997, 3 (3): 215-226. 10.1089/acm.1997.3.215.View ArticlePubMed
- Jacobs DR, Ainsworth BE, Hartman TJ, Leon AS: A simultaneous evaluation of 10 commonly used physical activity questionnaires. Med Sci Sports Exerc. 1993, 25 (1): 81-91. 10.1249/00005768-199301000-00012.View ArticlePubMed
- Radloff L: <br />The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977, 1: 385-10.1177/014662167700100306.View Article
- Hopko DR, Bell JL, Armento ME, Robertson SM, Hunt MK, Wolf NJ, Mullane C: The phenomenology and screening of clinical depression in cancer patients. J Psychosoc Oncol. 2008, 26 (1): 31-51.View ArticlePubMed
- Chang VT, Hwang SS, Feuerman M: Validation of the Edmonton symptom assessment scale. Cancer. 2000, 88 (9): 2164-2171. 10.1002/(SICI)1097-0142(20000501)88:9<2164::AID-CNCR24>3.0.CO;2-5.View ArticlePubMed
- Tremblay A, Sevigny J, Leblanc C, Bouchard C: The reproducibility of a three-day dietary record. Nutr Res. 1983, 3 (6): 819-830. 10.1016/S0271-5317(83)80035-9.View Article
- Chicago Dietetic Association, South Suburban Dietetic Association (Ill.): Manual of clinical dietetics. Dietitian's of Canada. 2000, Chicago, Ill: American Dietetic Association, 6
- Lau DC, Obesity Canada Clinical Practice Guidelines Steering Committee and Expert Panel: Synopsis of the 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children. CMAJ. 2007, 176 (8): 1103-1106. 10.1503/cmaj.070306.PubMed CentralView ArticlePubMed
- Canadian Society for Exercise Physiology: The Canadian physical activity, fitness & lifestyle approach (CPAFLA): CSEP- health and fitness program's health-related appriasal and counselling strategy. 2003, Ottawa, Ontario: Canadian Society for Exercise Physiology, 3
- Rikli R, Jones J: Senior fitness test manual. 2001, Champaign Il: Human Kinetics
- Fleishman E: The structure and measurement of physical fitness. 1964, Oxford, England: Prentice-Hall
- Brasel KJ: Quality-of-life assessment in palliative care. Am J Hosp Palliat Care. 2007, 24 (3): 231-235. 10.1177/1049909107301778.View ArticlePubMed
- Seruga B, Zhang H, Bernstein LJ, Tannock IF: Cytokines and their relationship to the symptoms and outcome of cancer. Nat Rev Cancer. 2008, 8 (11): 887-899. 10.1038/nrc2507.View ArticlePubMed
- Baldwin C: Nutritional support for malnourished patients with cancer. Curr Opin Support Palliat Care. 2011, 5 (1): 29-36. 10.1097/SPC.0b013e328343a05d.View ArticlePubMed
- Faul F, Erdfelder E, Lang AG, Buchner A: G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007, 39 (2): 175-191. 10.3758/BF03193146.View ArticlePubMed
- Buchner A, Erdfelder E, Faul F: Handbuch quantitative methoden. 1996, Weinheim: Psychologie Verlags Union
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/12/446/prepub
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