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Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links in vitroand in clinical acquired resistant tumour samples

  • Victoria J Spanswick1,
  • Helen L Lowe1,
  • Claire Newton1,
  • John P Bingham1,
  • Alessia Bagnobianchi1,
  • Konstantinos Kiakos1,
  • Charles Craddock2,
  • Jonathan A Ledermann3,
  • Daniel Hochhauser1 and
  • John A Hartley1Email author
BMC Cancer201212:436

DOI: 10.1186/1471-2407-12-436

Received: 27 May 2012

Accepted: 17 September 2012

Published: 28 September 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
27 May 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
19 Jun 2012 Reviewed Reviewer Report - Petra Heffeter
25 Jun 2012 Reviewed Reviewer Report - randy Legerski
27 Jun 2012 Reviewed Reviewer Report - christine canman
25 Jul 2012 Author responded Author comments - John Hartley
Resubmission - Version 3
25 Jul 2012 Submitted Manuscript version 3
21 Aug 2012 Reviewed Reviewer Report - Petra Heffeter
5 Sep 2012 Reviewed Reviewer Report - christine canman
Resubmission - Version 4
Submitted Manuscript version 4
17 Sep 2012 Editorially accepted
28 Sep 2012 Article published 10.1186/1471-2407-12-436

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article.. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

CR-UK Drug-DNA Interactions Research Group, UCL Cancer Institute, Paul O’Gorman Building
Centre for Clinical Haematology, Queen Elizabeth Hospital
CR-UK/UCL Cancer Clinical Trials Centre