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Natural resistance to cancers: a Darwinian hypothesis to explain Peto’s paradox

  • Benjamin Roche1, 8Email author,
  • Michael E Hochberg2, 3, 8,
  • Aleah F Caulin4,
  • Carlo C Maley5,
  • Robert A Gatenby6,
  • Dorothée Misse7, 8 and
  • Frédéric Thomas7, 8
BMC Cancer201212:387

DOI: 10.1186/1471-2407-12-387

Received: 30 April 2012

Accepted: 27 August 2012

Published: 3 September 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
30 Apr 2012 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
6 May 2012 Reviewed Reviewer Report - Darryl Shibata
4 Jun 2012 Reviewed Reviewer Report - John Nagy
19 Jul 2012 Author responded Author comments - Benjamin Roche
Resubmission - Version 3
19 Jul 2012 Submitted Manuscript version 3
1 Aug 2012 Reviewed Reviewer Report - Darryl Shibata
Resubmission - Version 4
Submitted Manuscript version 4
27 Aug 2012 Editorially accepted
3 Sep 2012 Article published 10.1186/1471-2407-12-387

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

ISEM, Institut des Sciences de l’Evolution, Université Montpellier 2, CNRS
Santa Fe Institute
Genomics and Computational Biology Graduate Program, University of Pennsylvania
Center for Evolution and Cancer, Helen Diller Family Comprehensive Cancer Center and Department of Surgery, University of California San Francisco
Departments of Radiology and Integrated Mathematical Oncology, the Moffitt Cancer Center
CREEC, Universite Montpellier 2