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Association of postmenopausal endogenous sex hormones with global methylation level of leukocyte DNA among Japanese women

  • Motoki Iwasaki1Email author,
  • Hiroe Ono2, 3,
  • Aya Kuchiba2, 4,
  • Yoshio Kasuga5,
  • Shiro Yokoyama6,
  • Hiroshi Onuma6,
  • Hideki Nishimura7,
  • Ritsu Kusama8,
  • Teruhiko Yoshida2 and
  • Shoichiro Tsugane1
BMC Cancer201212:323

DOI: 10.1186/1471-2407-12-323

Received: 15 December 2011

Accepted: 17 July 2012

Published: 29 July 2012

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
15 Dec 2011 Submitted Original manuscript
Resubmission - Version 2
Submitted Manuscript version 2
29 Mar 2012 Reviewed Reviewer Report - Unhee Lim
2 May 2012 Reviewed Reviewer Report - Heather Nelson
31 May 2012 Author responded Author comments - Motoki Iwasaki
Resubmission - Version 3
31 May 2012 Submitted Manuscript version 3
2 Jul 2012 Reviewed Reviewer Report - Heather Nelson
Resubmission - Version 4
Submitted Manuscript version 4
17 Jul 2012 Editorially accepted
29 Jul 2012 Article published 10.1186/1471-2407-12-323

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article.. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center
Division of Genetics, National Cancer Center Research Institute
Biomedical Science PhD Program, Tokyo Medical and Dental University
Department of Medical Oncology, Dana-Farber Cancer Institute
Department of Surgery, Nagano Matsushiro General Hospital
Department of Breast and Thyroid Surgery, Nagano Red Cross Hospital
Department of Surgery, Nagano Municipal Hospital
Department of Surgery, Nagano Hokushin General Hospital