Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas

  • Yosuke Hashimoto1,

    Affiliated with

    • Marek Skacel2,

      Affiliated with

      • Ian C Lavery3,

        Affiliated with

        • Abir L Mukherjee4,

          Affiliated with

          • Graham Casey3, 4, 5 and

            Affiliated with

            • Josephine C Adams1, 2, 5Email author

              Affiliated with

              BMC Cancer201111:488

              DOI: 10.1186/1471-2407-11-488

              Received: 15 November 2011

              Accepted: 21 November 2011

              Published: 21 November 2011

              Correction [1]: It was recently brought to our attention that, although the statistical analyses in Table four had passed the original peer-review of this paper, the risk ratio and value of the lower 95% confidence interval for some of the variables in Table four were not consistent with the p values. We have repeated the multi-variant statistical analysis of the original data with StatView software. This analysis produced different values for the risk ratios and 95% confidence intervals for variables other than age. The corrected Table four is presented below (table 1). The p values are unchanged, thus the original conclusions of the article are not altered.
              Table 1

              Corrected table four

              Table 4a. Cox's proportional hazard analysis in stage I-IV patients

              Variables

              Risk ratio (95% confidence Interval)

              p

              Age (≥ 65 yrs)

              1.618 (0/944-2.774)

              0.080

              Gender (male)

              1.626 (0.965-2.740)

              0.068

              Lymph node metastasis (N1, 2)

              0.253 (0.146-0.439)

              < 0.001*

              Distant metastasis (M1)

              0.581 (0.317-1.066)

              0.797

              Tumour location (distal)

              0.963 (0.550-1.686)

              0.894

              Fascin (high)

              0.548 (0.272-1.104)

              0.925

              Table 4b. Cox's proportional hazard analysis in stage III/IV patients

              Variable

              Risk ratio (95% confidence Interval)

              p

              Age (> 65 yrs)

              1.259 (0.683-2.318)

              0.460

              Gender (male)

              1.659 (0.886-3.108)

              0.114

              Lymph node metastasis (N1, 2)

              1.032 (0.358-2.972)

              0.934

              Distant metastasis (M1)

              0.803 (0.381-1.697)

              0.566

              Tumour location (distal)

              0.683 (0.362-1.289)

              0.240

              Fascin (high)

              0.435 (0.197-0.957)

              0.039*

              Authors’ Affiliations

              (1)
              Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic
              (2)
              Department of Anatomic Pathology, The Cleveland Clinic
              (3)
              Department of Colorectal Surgery, The Cleveland Clinic
              (4)
              Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic
              (5)
              Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, The Cleveland Clinic

              References

              1. Hashimoto Y, Skacel M, Lavery IC, Mukherjee AL, Casey G, Adams JC: Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas. BMC Cancer 2006, 6:241.PubMedView Article
              2. Pre-publication history

                1. The pre-publication history for this paper can be accessed here:http://​www.​biomedcentral.​com/​1471-2407/​11/​488/​prepub

              Copyright

              © Hashimoto et al; licensee BioMed Central Ltd. 2011

              This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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